3RHY
Crystal structure of the dimethylarginine dimethylaminohydrolase adduct with 4-chloro-2-hydroxymethylpyridine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000052 | biological_process | citrulline metabolic process |
| A | 0006525 | biological_process | arginine metabolic process |
| A | 0016403 | molecular_function | dimethylargininase activity |
| A | 0016597 | molecular_function | amino acid binding |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0045429 | biological_process | positive regulation of nitric oxide biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000052 | biological_process | citrulline metabolic process |
| B | 0006525 | biological_process | arginine metabolic process |
| B | 0016403 | molecular_function | dimethylargininase activity |
| B | 0016597 | molecular_function | amino acid binding |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0045429 | biological_process | positive regulation of nitric oxide biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE HM3 A 255 |
| Chain | Residue |
| A | PHE63 |
| A | ASP66 |
| A | HIS162 |
| A | ASP244 |
| A | CYS249 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE HM3 B 255 |
| Chain | Residue |
| B | CYS249 |
| B | PHE63 |
| B | HIS162 |
| B | ASP244 |
| B | GLY245 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"11473257","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"16634643","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18482699","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"11473257","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"16634643","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18482699","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11473257","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16634643","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
