Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3RHP

Crystal structure of the C707A mutant of the C-Terminal domain of 10'FORMYLTETRAHYDROFOLATE DEHYDROGENASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 2

Chain	Residue
A	ARG636
A	PRO641

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 6

Chain	Residue
A	LYS669
A	LEU893
A	ARG894
A	ILE895
B	GLY881
B	LYS882
B	HOH1001

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 3

Chain	Residue
A	ARG551
A	ARG554
A	HOH1144

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 4

Chain	Residue
A	ASN738
A	GLU741
A	ARG781
A	HOH1109
A	HOH1160

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 5

Chain	Residue
A	GLY881
A	LYS882
A	HOH1003
B	LYS669
B	LEU893
B	ARG894
B	ILE895
B	HOH1035

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1

Chain	Residue
A	LYS852
C	ARG554

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL A 7

Chain	Residue
A	TYR575
A	ASN706
A	ASN864
A	THR866
A	HOH1102

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 3

Chain	Residue
B	ARG554
D	ASP851
D	LYS852

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 4

Chain	Residue
B	ASP851
B	LYS852
B	HOH1110
D	ARG554

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 5

Chain	Residue
B	ARG636
B	PRO641

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 6

Chain	Residue
B	ARG551
B	ARG554

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 7

Chain	Residue
A	ASN548
B	GLN528
B	HOH1106
B	HOH1149

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 8

Chain	Residue
A	GLN528
B	ASN548
B	HOH1111
B	HOH1153

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 9

Chain	Residue
B	ASN738
B	GLU741
B	ARG781
B	HOH1136

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 10

Chain	Residue
B	TYR575
B	MET578
B	ASN706
B	THR866
B	HOH1113

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 1

Chain	Residue
C	ARG636
C	PRO641

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 2

Chain	Residue
A	ARG554
C	LYS852
C	HOH1061

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 7

Chain	Residue
A	LEU416
A	THR417
C	LYS415
C	ARG742

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 3

Chain	Residue
A	LYS852
C	ARG551
C	ARG554
C	HOH1162

site_id	CC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 4

Chain	Residue
C	ASN548
D	GLN528

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 5

Chain	Residue
C	ASN738
C	ARG781
C	HOH1034
C	HOH1161

site_id	CC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 6

Chain	Residue
C	LYS669
C	ARG894
C	ILE895
D	GLY881
D	LYS882

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL C 8

Chain	Residue
C	TYR575
C	ASN706
C	ILE708
C	THR866
C	HOH1185

site_id	CC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 1

Chain	Residue
D	ARG636
D	PRO641

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 2

Chain	Residue
D	ARG551
D	ARG554
D	HOH1169

site_id	CC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 3

Chain	Residue
D	THR445
D	ASN738
D	ARG781

site_id	CC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 D 4

Chain	Residue
C	LYS882
D	LYS669
D	LEU893
D	ARG894
D	ILE895
D	HOH1073
D	HOH1099
D	HOH1177
C	PHE875
C	GLY881

site_id	DC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL D 5

Chain	Residue
D	TYR575
D	ASN706
D	ASN864
D	THR866
D	HOH1182

Functional Information from PROSITE/UniProt

site_id	PS00687
Number of Residues	8
Details	ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGKSP

Chain	Residue	Details
A	LEU672-PRO679

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1940
Details	Region: {"description":"Aldehyde dehydrogenase domain","evidences":[{"source":"PubMed","id":"10585460","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"17302434","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"17302434","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21540484","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2O2Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RHO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	44
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17302434","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21540484","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2O2Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2O2R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RHJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RHL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RHR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"17302434","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21540484","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2O2Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RHJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RHL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RHO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RHR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21540484","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3RHO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"O75891","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8K009","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8R0Y6","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q3SY69","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	1
Details	M-CSA 766

Chain	Residue	Details
A	ALA707

site_id	MCSA2
Number of Residues	1
Details	M-CSA 766

Chain	Residue	Details
B	ALA707

site_id	MCSA3
Number of Residues	1
Details	M-CSA 766

Chain	Residue	Details
C	ALA707

site_id	MCSA4
Number of Residues	1
Details	M-CSA 766

Chain	Residue	Details
D	ALA707

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)