Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3RGD

Iron loaded frog M ferritin. Short soaking time

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004322	molecular_function	ferroxidase activity
A	0005737	cellular_component	cytoplasm
A	0006826	biological_process	iron ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0008198	molecular_function	ferrous iron binding
A	0008199	molecular_function	ferric iron binding
A	0016491	molecular_function	oxidoreductase activity
A	0046872	molecular_function	metal ion binding
B	0004322	molecular_function	ferroxidase activity
B	0005737	cellular_component	cytoplasm
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0008198	molecular_function	ferrous iron binding
B	0008199	molecular_function	ferric iron binding
B	0016491	molecular_function	oxidoreductase activity
B	0046872	molecular_function	metal ion binding
C	0004322	molecular_function	ferroxidase activity
C	0005737	cellular_component	cytoplasm
C	0006826	biological_process	iron ion transport
C	0006879	biological_process	intracellular iron ion homeostasis
C	0008198	molecular_function	ferrous iron binding
C	0008199	molecular_function	ferric iron binding
C	0016491	molecular_function	oxidoreductase activity
C	0046872	molecular_function	metal ion binding
D	0004322	molecular_function	ferroxidase activity
D	0005737	cellular_component	cytoplasm
D	0006826	biological_process	iron ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0008198	molecular_function	ferrous iron binding
D	0008199	molecular_function	ferric iron binding
D	0016491	molecular_function	oxidoreductase activity
D	0046872	molecular_function	metal ion binding
E	0004322	molecular_function	ferroxidase activity
E	0005737	cellular_component	cytoplasm
E	0006826	biological_process	iron ion transport
E	0006879	biological_process	intracellular iron ion homeostasis
E	0008198	molecular_function	ferrous iron binding
E	0008199	molecular_function	ferric iron binding
E	0016491	molecular_function	oxidoreductase activity
E	0046872	molecular_function	metal ion binding
F	0004322	molecular_function	ferroxidase activity
F	0005737	cellular_component	cytoplasm
F	0006826	biological_process	iron ion transport
F	0006879	biological_process	intracellular iron ion homeostasis
F	0008198	molecular_function	ferrous iron binding
F	0008199	molecular_function	ferric iron binding
F	0016491	molecular_function	oxidoreductase activity
F	0046872	molecular_function	metal ion binding
G	0004322	molecular_function	ferroxidase activity
G	0005737	cellular_component	cytoplasm
G	0006826	biological_process	iron ion transport
G	0006879	biological_process	intracellular iron ion homeostasis
G	0008198	molecular_function	ferrous iron binding
G	0008199	molecular_function	ferric iron binding
G	0016491	molecular_function	oxidoreductase activity
G	0046872	molecular_function	metal ion binding
H	0004322	molecular_function	ferroxidase activity
H	0005737	cellular_component	cytoplasm
H	0006826	biological_process	iron ion transport
H	0006879	biological_process	intracellular iron ion homeostasis
H	0008198	molecular_function	ferrous iron binding
H	0008199	molecular_function	ferric iron binding
H	0016491	molecular_function	oxidoreductase activity
H	0046872	molecular_function	metal ion binding
I	0004322	molecular_function	ferroxidase activity
I	0005737	cellular_component	cytoplasm
I	0006826	biological_process	iron ion transport
I	0006879	biological_process	intracellular iron ion homeostasis
I	0008198	molecular_function	ferrous iron binding
I	0008199	molecular_function	ferric iron binding
I	0016491	molecular_function	oxidoreductase activity
I	0046872	molecular_function	metal ion binding
J	0004322	molecular_function	ferroxidase activity
J	0005737	cellular_component	cytoplasm
J	0006826	biological_process	iron ion transport
J	0006879	biological_process	intracellular iron ion homeostasis
J	0008198	molecular_function	ferrous iron binding
J	0008199	molecular_function	ferric iron binding
J	0016491	molecular_function	oxidoreductase activity
J	0046872	molecular_function	metal ion binding
K	0004322	molecular_function	ferroxidase activity
K	0005737	cellular_component	cytoplasm
K	0006826	biological_process	iron ion transport
K	0006879	biological_process	intracellular iron ion homeostasis
K	0008198	molecular_function	ferrous iron binding
K	0008199	molecular_function	ferric iron binding
K	0016491	molecular_function	oxidoreductase activity
K	0046872	molecular_function	metal ion binding
L	0004322	molecular_function	ferroxidase activity
L	0005737	cellular_component	cytoplasm
L	0006826	biological_process	iron ion transport
L	0006879	biological_process	intracellular iron ion homeostasis
L	0008198	molecular_function	ferrous iron binding
L	0008199	molecular_function	ferric iron binding
L	0016491	molecular_function	oxidoreductase activity
L	0046872	molecular_function	metal ion binding
M	0004322	molecular_function	ferroxidase activity
M	0005737	cellular_component	cytoplasm
M	0006826	biological_process	iron ion transport
M	0006879	biological_process	intracellular iron ion homeostasis
M	0008198	molecular_function	ferrous iron binding
M	0008199	molecular_function	ferric iron binding
M	0016491	molecular_function	oxidoreductase activity
M	0046872	molecular_function	metal ion binding
N	0004322	molecular_function	ferroxidase activity
N	0005737	cellular_component	cytoplasm
N	0006826	biological_process	iron ion transport
N	0006879	biological_process	intracellular iron ion homeostasis
N	0008198	molecular_function	ferrous iron binding
N	0008199	molecular_function	ferric iron binding
N	0016491	molecular_function	oxidoreductase activity
N	0046872	molecular_function	metal ion binding
O	0004322	molecular_function	ferroxidase activity
O	0005737	cellular_component	cytoplasm
O	0006826	biological_process	iron ion transport
O	0006879	biological_process	intracellular iron ion homeostasis
O	0008198	molecular_function	ferrous iron binding
O	0008199	molecular_function	ferric iron binding
O	0016491	molecular_function	oxidoreductase activity
O	0046872	molecular_function	metal ion binding
P	0004322	molecular_function	ferroxidase activity
P	0005737	cellular_component	cytoplasm
P	0006826	biological_process	iron ion transport
P	0006879	biological_process	intracellular iron ion homeostasis
P	0008198	molecular_function	ferrous iron binding
P	0008199	molecular_function	ferric iron binding
P	0016491	molecular_function	oxidoreductase activity
P	0046872	molecular_function	metal ion binding
Q	0004322	molecular_function	ferroxidase activity
Q	0005737	cellular_component	cytoplasm
Q	0006826	biological_process	iron ion transport
Q	0006879	biological_process	intracellular iron ion homeostasis
Q	0008198	molecular_function	ferrous iron binding
Q	0008199	molecular_function	ferric iron binding
Q	0016491	molecular_function	oxidoreductase activity
Q	0046872	molecular_function	metal ion binding
R	0004322	molecular_function	ferroxidase activity
R	0005737	cellular_component	cytoplasm
R	0006826	biological_process	iron ion transport
R	0006879	biological_process	intracellular iron ion homeostasis
R	0008198	molecular_function	ferrous iron binding
R	0008199	molecular_function	ferric iron binding
R	0016491	molecular_function	oxidoreductase activity
R	0046872	molecular_function	metal ion binding
S	0004322	molecular_function	ferroxidase activity
S	0005737	cellular_component	cytoplasm
S	0006826	biological_process	iron ion transport
S	0006879	biological_process	intracellular iron ion homeostasis
S	0008198	molecular_function	ferrous iron binding
S	0008199	molecular_function	ferric iron binding
S	0016491	molecular_function	oxidoreductase activity
S	0046872	molecular_function	metal ion binding
T	0004322	molecular_function	ferroxidase activity
T	0005737	cellular_component	cytoplasm
T	0006826	biological_process	iron ion transport
T	0006879	biological_process	intracellular iron ion homeostasis
T	0008198	molecular_function	ferrous iron binding
T	0008199	molecular_function	ferric iron binding
T	0016491	molecular_function	oxidoreductase activity
T	0046872	molecular_function	metal ion binding
U	0004322	molecular_function	ferroxidase activity
U	0005737	cellular_component	cytoplasm
U	0006826	biological_process	iron ion transport
U	0006879	biological_process	intracellular iron ion homeostasis
U	0008198	molecular_function	ferrous iron binding
U	0008199	molecular_function	ferric iron binding
U	0016491	molecular_function	oxidoreductase activity
U	0046872	molecular_function	metal ion binding
V	0004322	molecular_function	ferroxidase activity
V	0005737	cellular_component	cytoplasm
V	0006826	biological_process	iron ion transport
V	0006879	biological_process	intracellular iron ion homeostasis
V	0008198	molecular_function	ferrous iron binding
V	0008199	molecular_function	ferric iron binding
V	0016491	molecular_function	oxidoreductase activity
V	0046872	molecular_function	metal ion binding
W	0004322	molecular_function	ferroxidase activity
W	0005737	cellular_component	cytoplasm
W	0006826	biological_process	iron ion transport
W	0006879	biological_process	intracellular iron ion homeostasis
W	0008198	molecular_function	ferrous iron binding
W	0008199	molecular_function	ferric iron binding
W	0016491	molecular_function	oxidoreductase activity
W	0046872	molecular_function	metal ion binding
X	0004322	molecular_function	ferroxidase activity
X	0005737	cellular_component	cytoplasm
X	0006826	biological_process	iron ion transport
X	0006879	biological_process	intracellular iron ion homeostasis
X	0008198	molecular_function	ferrous iron binding
X	0008199	molecular_function	ferric iron binding
X	0016491	molecular_function	oxidoreductase activity
X	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FE A 180

Chain	Residue
A	GLU24
A	GLU59
A	HIS62

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE A 181

Chain	Residue
A	GLU59
A	GLU104
A	GLN138
A	ASP141
A	HOH900

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE B 180

Chain	Residue
B	GLU59
B	HIS62
B	GLN138
B	GLU24

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE B 181

Chain	Residue
B	HIS55
B	GLU59
B	GLU104
B	ASP141

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE B 183

Chain	Residue
B	GLU131
E	GLU131
V	GLU131
V	HOH270

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE C 180

Chain	Residue
C	GLU24
C	GLU59
C	HIS62
C	GLN138

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE C 181

Chain	Residue
C	HIS55
C	GLU59
C	GLU104
C	HOH905

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FE C 183

Chain	Residue
C	GLU131
C	HOH741
S	GLU131

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE C 184

Chain	Residue
C	HIS170
F	HIS170
M	HIS170
V	HIS170

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE D 180

Chain	Residue
D	GLU24
D	GLU59
D	HIS62
D	GLN138
D	FE181

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE D 181

Chain	Residue
D	GLU59
D	GLU104
D	GLN138
D	ASP141
D	FE180

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FE D 183

Chain	Residue
D	GLU131
I	GLU131
W	GLU131

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE D 184

Chain	Residue
D	HIS170
K	HIS170
Q	HIS170
X	HIS170

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE E 180

Chain	Residue
E	GLU24
E	GLU59
E	HIS62
E	GLN138

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE E 181

Chain	Residue
E	HIS55
E	GLU59
E	GLU104
E	ASP141
E	HOH907

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE E 184

Chain	Residue
E	HIS170
L	HIS170
P	HIS170
W	HIS170
W	HOH185

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE F 180

Chain	Residue
F	GLU24
F	GLU59
F	HIS62
F	GLN138
F	FE181

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE F 181

Chain	Residue
F	GLU59
F	GLU104
F	GLN138
F	ASP141
F	FE180
F	HOH908

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FE F 183

Chain	Residue
F	GLU131
G	GLU131
O	GLU131

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE G 180

Chain	Residue
G	GLU24
G	GLU59
G	HIS62
G	GLN138
G	FE181

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE G 181

Chain	Residue
G	HIS55
G	GLU59
G	GLU104
G	ASP141
G	FE180

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE H 183

Chain	Residue
A	GLU131
H	GLU131
H	HOH733
X	GLU131

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE H 180

Chain	Residue
H	GLU24
H	GLU59
H	HIS62
H	GLN138

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE H 181

Chain	Residue
H	GLU104
H	GLN138
H	ASP141
H	HOH909
H	GLU59

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE I 184

Chain	Residue
B	HIS170
G	HIS170
H	HIS170
I	HIS170

site_id	CC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE I 180

Chain	Residue
I	GLU24
I	GLU59
I	HIS62
I	GLN138
I	FE181

site_id	CC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FE I 181

Chain	Residue
I	HIS55
I	GLU59
I	GLU104
I	ASP141
I	FE180
I	HOH910
I	HOH911

site_id	DC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE J 180

Chain	Residue
J	GLU24
J	GLU59
J	HIS62
J	FE181

site_id	DC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE J 181

Chain	Residue
J	HIS55
J	GLU59
J	GLU104
J	GLN138
J	ASP141
J	FE180

site_id	DC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FE J 183

Chain	Residue
J	GLU131
N	GLU131
Q	HOH797

site_id	DC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE K 180

Chain	Residue
K	GLU24
K	GLU59
K	HIS62
K	GLN138

site_id	DC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE K 181

Chain	Residue
K	GLU59
K	GLU104
K	GLN138
K	ASP141

site_id	DC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FE K 183

Chain	Residue
K	GLU131
P	GLU131
U	GLU131

site_id	DC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE L 180

Chain	Residue
L	GLU24
L	GLU59
L	HIS62
L	HOH912

site_id	DC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE L 181

Chain	Residue
L	HIS55
L	GLU59
L	GLU104
L	ASP141
L	HOH426

site_id	DC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE M 180

Chain	Residue
M	GLU24
M	GLU59
M	HIS62
M	GLN138
M	HOH913

site_id	EC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE M 181

Chain	Residue
M	GLU59
M	GLU104
M	GLN138
M	ASP141
M	HOH913

site_id	EC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE N 180

Chain	Residue
N	GLU24
N	GLU59
N	HIS62
N	GLN138

site_id	EC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE N 181

Chain	Residue
N	HIS55
N	GLU58
N	GLU59
N	GLU104
N	ASP141

site_id	EC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE N 184

Chain	Residue
N	HIS170
S	HIS170
T	HIS170
U	HIS170

site_id	EC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE O 184

Chain	Residue
A	HIS170
J	HIS170
O	HIS170
R	HIS170
R	HOH182

site_id	EC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE O 180

Chain	Residue
O	GLU24
O	GLU59
O	HIS62
O	GLN138

site_id	EC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE O 181

Chain	Residue
O	HIS55
O	GLU59
O	GLU104
O	ASP141

site_id	EC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE P 180

Chain	Residue
P	GLU24
P	GLU59
P	HIS62
P	HOH914

site_id	EC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FE P 181

Chain	Residue
P	GLU59
P	GLU104
P	ASP141

site_id	FC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE Q 180

Chain	Residue
Q	GLU24
Q	GLU59
Q	HIS62
Q	GLN138

site_id	FC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE Q 181

Chain	Residue
Q	GLU59
Q	GLU104
Q	GLN138
Q	ASP141

site_id	FC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE R 180

Chain	Residue
R	GLU24
R	GLU59
R	HIS62
R	GLN138

site_id	FC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE R 181

Chain	Residue
R	GLU59
R	GLU104
R	ASP141
R	HOH916

site_id	FC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE S 180

Chain	Residue
S	GLU24
S	GLU59
S	HIS62
S	HOH917

site_id	FC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE S 181

Chain	Residue
S	HIS55
S	GLU59
S	GLU104
S	ASP141

site_id	FC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE T 183

Chain	Residue
L	GLU131
M	GLU131
T	GLU131
T	HOH342

site_id	FC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE T 180

Chain	Residue
T	GLU24
T	GLU59
T	HIS62
T	GLN138
T	HOH410

site_id	FC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE T 181

Chain	Residue
T	HIS55
T	GLU59
T	GLU104
T	ASP141

site_id	GC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE U 180

Chain	Residue
U	GLU24
U	GLU59
U	HIS62
U	GLN138

site_id	GC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE U 181

Chain	Residue
U	GLU59
U	GLU104
U	ASP141
U	HOH918

site_id	GC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE V 180

Chain	Residue
V	GLU24
V	GLU59
V	HIS62
V	GLN138

site_id	GC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE FE V 181

Chain	Residue
V	GLU59
V	GLU104
V	ASP141

site_id	GC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE W 180

Chain	Residue
W	GLU24
W	GLU59
W	HIS62
W	GLN138
W	FE181

site_id	GC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE W 181

Chain	Residue
W	HIS55
W	GLU59
W	GLU104
W	GLN138
W	ASP141
W	FE180

site_id	GC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE X 180

Chain	Residue
X	GLU24
X	GLU59
X	HIS62
X	GLN138

site_id	GC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE FE X 181

Chain	Residue
X	HIS55
X	GLU59
X	GLU104
X	ASP141

Functional Information from PROSITE/UniProt

site_id	PS00204
Number of Residues	21
Details	FERRITIN_2 Ferritin iron-binding regions signature 2. DphLCDFLEseYLeeqvkdIK

Chain	Residue	Details
A	ASP123-LYS143

site_id	PS00540
Number of Residues	19
Details	FERRITIN_1 Ferritin iron-binding regions signature 1. EeREhaEKFMkyQNkRgGR

Chain	Residue	Details
A	GLU58-ARG76

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3576
Details	Domain: {"description":"Ferritin-like diiron","evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	144
Details	Binding site: {}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)