3RFU

Crystal structure of a copper-transporting PIB-type ATPase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0005215	molecular_function	transporter activity
A	0005507	molecular_function	copper ion binding
A	0005524	molecular_function	ATP binding
A	0005886	cellular_component	plasma membrane
A	0006812	biological_process	monoatomic cation transport
A	0006825	biological_process	copper ion transport
A	0006878	biological_process	intracellular copper ion homeostasis
A	0015662	molecular_function	P-type ion transporter activity
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
A	0043682	molecular_function	P-type divalent copper transporter activity
A	0046872	molecular_function	metal ion binding
A	0055070	biological_process	copper ion homeostasis
A	0060003	biological_process	copper ion export
A	0140581	molecular_function	P-type monovalent copper transporter activity
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0005215	molecular_function	transporter activity
B	0005507	molecular_function	copper ion binding
B	0005524	molecular_function	ATP binding
B	0005886	cellular_component	plasma membrane
B	0006812	biological_process	monoatomic cation transport
B	0006825	biological_process	copper ion transport
B	0006878	biological_process	intracellular copper ion homeostasis
B	0015662	molecular_function	P-type ion transporter activity
B	0016020	cellular_component	membrane
B	0016887	molecular_function	ATP hydrolysis activity
B	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
B	0043682	molecular_function	P-type divalent copper transporter activity
B	0046872	molecular_function	metal ion binding
B	0055070	biological_process	copper ion homeostasis
B	0060003	biological_process	copper ion export
B	0140581	molecular_function	P-type monovalent copper transporter activity
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0005215	molecular_function	transporter activity
C	0005507	molecular_function	copper ion binding
C	0005524	molecular_function	ATP binding
C	0005886	cellular_component	plasma membrane
C	0006812	biological_process	monoatomic cation transport
C	0006825	biological_process	copper ion transport
C	0006878	biological_process	intracellular copper ion homeostasis
C	0015662	molecular_function	P-type ion transporter activity
C	0016020	cellular_component	membrane
C	0016887	molecular_function	ATP hydrolysis activity
C	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
C	0043682	molecular_function	P-type divalent copper transporter activity
C	0046872	molecular_function	metal ion binding
C	0055070	biological_process	copper ion homeostasis
C	0060003	biological_process	copper ion export
C	0140581	molecular_function	P-type monovalent copper transporter activity
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0005215	molecular_function	transporter activity
D	0005507	molecular_function	copper ion binding
D	0005524	molecular_function	ATP binding
D	0005886	cellular_component	plasma membrane
D	0006812	biological_process	monoatomic cation transport
D	0006825	biological_process	copper ion transport
D	0006878	biological_process	intracellular copper ion homeostasis
D	0015662	molecular_function	P-type ion transporter activity
D	0016020	cellular_component	membrane
D	0016887	molecular_function	ATP hydrolysis activity
D	0019829	molecular_function	ATPase-coupled monoatomic cation transmembrane transporter activity
D	0043682	molecular_function	P-type divalent copper transporter activity
D	0046872	molecular_function	metal ion binding
D	0055070	biological_process	copper ion homeostasis
D	0060003	biological_process	copper ion export
D	0140581	molecular_function	P-type monovalent copper transporter activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ALF A 995

Chain	Residue
A	THR277
A	MG996
A	ASP426
A	LYS427
A	THR428
A	THR577
A	GLY578
A	ASP624
A	ASN627
A	ASP628

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 996

Chain	Residue
A	THR428
A	ASP624
A	ALF995

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE K A 997

Chain	Residue
A	GLU99
A	GLU189

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ALF B 995

Chain	Residue
B	THR277
B	ASP426
B	LYS427
B	THR428
B	THR577
B	GLY578
B	ASN627
B	ASP628
B	MG996

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 996

Chain	Residue
B	ASP426
B	THR428
B	ASP624
B	ALF995

---

site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE K B 997

Chain	Residue
B	GLU99

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ALF C 995

Chain	Residue
C	THR277
C	ASP426
C	LYS427
C	THR428
C	THR577
C	GLY578
C	ASN627
C	ASP628
C	MG996

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG C 996

Chain	Residue
C	ASP426
C	THR428
C	ASP624
C	ALF995

---

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE K C 997

Chain	Residue
C	GLU99

---

site_id	BC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ALF D 995

Chain	Residue
D	THR277
D	ASP426
D	LYS427
D	THR428
D	THR577
D	GLY578
D	ASN627
D	ASP628
D	MG996

---

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG D 996

Chain	Residue
D	ASP426
D	THR428
D	ASP624
D	ALF995

---

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE K D 997

Chain	Residue
D	GLU99

---

Functional Information from PROSITE/UniProt

site_id	PS00154
Number of Residues	7
Details	ATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT

Chain	Residue	Details
A	ASP426-THR432

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	640
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	PHE85-LEU105
B	SER114-PHE134
B	PHE149-TRP169
B	VAL183-VAL203
B	GLY341-LEU361
B	TYR369-ALA389
B	LEU682-PRO702
B	LEU706-ILE726
C	PHE85-LEU105
C	SER114-PHE134
C	PHE149-TRP169
A	SER114-PHE134
C	VAL183-VAL203
C	GLY341-LEU361
C	TYR369-ALA389
C	LEU682-PRO702
C	LEU706-ILE726
D	PHE85-LEU105
D	SER114-PHE134
D	PHE149-TRP169
D	VAL183-VAL203
D	GLY341-LEU361
A	PHE149-TRP169
D	TYR369-ALA389
D	LEU682-PRO702
D	LEU706-ILE726
A	VAL183-VAL203
A	GLY341-LEU361
A	TYR369-ALA389
A	LEU682-PRO702
A	LEU706-ILE726
B	PHE85-LEU105

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: 4-aspartylphosphate intermediate => ECO:0000305|Ref.4, ECO:0000305|Ref.5

Chain	Residue	Details
A	ASP426
B	ASP426
C	ASP426
D	ASP426

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:24317491, ECO:0000269|Ref.4, ECO:0000269|Ref.5, ECO:0007744|PDB:4BBJ, ECO:0007744|PDB:4BEV, ECO:0007744|PDB:4BYG

Chain	Residue	Details
A	ASP426
D	ASP426
D	THR428
D	ASP624
A	THR428
A	ASP624
B	ASP426
B	THR428
B	ASP624
C	ASP426
C	THR428
C	ASP624

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	SITE: Important for copper transport => ECO:0000303|PubMed:24317491

Chain	Residue	Details
A	GLU189
C	CYS382
C	CYS384
C	MET717
D	GLU189
D	CYS382
D	CYS384
D	MET717
A	CYS382
A	CYS384
A	MET717
B	GLU189
B	CYS382
B	CYS384
B	MET717
C	GLU189

---