3RC0
Human SETD6 in complex with RelA Lys310 peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0018022 | biological_process | peptidyl-lysine methylation |
| A | 0018026 | biological_process | peptidyl-lysine monomethylation |
| A | 0019827 | biological_process | stem cell population maintenance |
| A | 0032088 | biological_process | negative regulation of NF-kappaB transcription factor activity |
| A | 0032259 | biological_process | methylation |
| A | 0048863 | biological_process | stem cell differentiation |
| A | 0050727 | biological_process | regulation of inflammatory response |
| A | 0051059 | molecular_function | NF-kappaB binding |
| A | 1904047 | molecular_function | S-adenosyl-L-methionine binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0018022 | biological_process | peptidyl-lysine methylation |
| B | 0018026 | biological_process | peptidyl-lysine monomethylation |
| B | 0019827 | biological_process | stem cell population maintenance |
| B | 0032088 | biological_process | negative regulation of NF-kappaB transcription factor activity |
| B | 0032259 | biological_process | methylation |
| B | 0048863 | biological_process | stem cell differentiation |
| B | 0050727 | biological_process | regulation of inflammatory response |
| B | 0051059 | molecular_function | NF-kappaB binding |
| B | 1904047 | molecular_function | S-adenosyl-L-methionine binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 474 |
| Chain | Residue |
| A | LEU150 |
| A | GLY151 |
| A | ARG152 |
| A | LEU153 |
| A | PHE158 |
| A | GLN215 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 475 |
| Chain | Residue |
| A | GLU187 |
| A | SER120 |
| A | TRP122 |
| A | ASN183 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 476 |
| Chain | Residue |
| A | ARG31 |
| A | LEU424 |
| A | TYR427 |
| A | ALA428 |
| A | HOH521 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 477 |
| Chain | Residue |
| A | GLU396 |
| A | GLU397 |
| A | GLY398 |
| A | SER399 |
| B | PRO136 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 478 |
| Chain | Residue |
| A | VAL300 |
| A | TYR444 |
| A | TRP449 |
| A | GLN452 |
| A | HOH590 |
| B | LYS441 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 479 |
| Chain | Residue |
| A | ARG30 |
| A | LEU34 |
| A | LEU36 |
| A | HOH651 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 480 |
| Chain | Residue |
| A | HOH49 |
| A | LEU253 |
| A | VAL300 |
| A | SAM484 |
| A | HOH590 |
| A | HOH595 |
| B | LYS441 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 481 |
| Chain | Residue |
| A | ASN440 |
| A | GLU442 |
| B | GLY74 |
| B | EDO477 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 482 |
| Chain | Residue |
| A | LEU362 |
| A | GLU364 |
| A | GLU365 |
| A | GLU366 |
| A | HOH628 |
| A | HOH701 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 483 |
| Chain | Residue |
| A | GLN324 |
| A | ASN418 |
| A | LEU422 |
| A | GLN425 |
| A | HOH563 |
| A | HOH576 |
| site_id | BC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE SAM A 484 |
| Chain | Residue |
| A | VAL72 |
| A | ALA73 |
| A | GLY74 |
| A | TYR75 |
| A | ALA222 |
| A | TYR223 |
| A | ASP248 |
| A | ILE249 |
| A | LEU250 |
| A | ASN251 |
| A | HIS252 |
| A | TYR285 |
| A | TYR297 |
| A | PHE299 |
| A | EDO480 |
| A | HOH523 |
| A | HOH551 |
| A | HOH560 |
| A | HOH578 |
| A | HOH596 |
| A | HOH619 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 474 |
| Chain | Residue |
| B | VAL300 |
| B | TYR444 |
| B | TRP449 |
| B | GLN452 |
| B | HOH562 |
| B | HOH603 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 475 |
| Chain | Residue |
| B | GLY170 |
| B | THR171 |
| B | GLY172 |
| B | GLU175 |
| B | GLN314 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 476 |
| Chain | Residue |
| A | GLU197 |
| A | ARG208 |
| B | ASN255 |
| B | HOH649 |
| site_id | BC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE EDO B 477 |
| Chain | Residue |
| A | ASN440 |
| A | LYS441 |
| A | GLU442 |
| A | EDO481 |
| B | VAL72 |
| B | ALA73 |
| B | TRP449 |
| B | SAM480 |
| B | HOH528 |
| B | HOH582 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 478 |
| Chain | Residue |
| B | SER120 |
| B | ASN183 |
| B | GLU187 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 479 |
| Chain | Residue |
| B | GLU154 |
| B | TRP159 |
| B | TRP449 |
| B | ARG450 |
| B | GLN453 |
| B | HOH496 |
| site_id | BC9 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE SAM B 480 |
| Chain | Residue |
| B | VAL72 |
| B | ALA73 |
| B | GLY74 |
| B | TYR75 |
| B | ALA222 |
| B | TYR223 |
| B | ASP248 |
| B | ILE249 |
| B | LEU250 |
| B | ASN251 |
| B | HIS252 |
| B | TYR285 |
| B | TYR297 |
| B | PHE299 |
| B | EDO477 |
| B | HOH545 |
| B | HOH547 |
| B | HOH574 |
| B | HOH593 |
| B | HOH600 |
| B | HOH608 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21515635","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-methylated lysine; by autocatalysis","evidences":[{"source":"PubMed","id":"30189201","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-methylated lysine; by autocatalysis","evidences":[{"source":"PubMed","id":"30189201","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-methyllysine; by SETD6; alternate","evidences":[{"source":"UniProtKB","id":"Q04207","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC/PRKCZ","evidences":[{"source":"UniProtKB","id":"Q04207","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
