3RBF

Crystal structure of Human aromatic L-amino acid decarboxylase (AADC) in the apo form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001822	biological_process	kidney development
A	0004058	molecular_function	aromatic-L-amino-acid decarboxylase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006520	biological_process	amino acid metabolic process
A	0006584	biological_process	catecholamine metabolic process
A	0009636	biological_process	response to toxic substance
A	0010467	biological_process	gene expression
A	0016829	molecular_function	lyase activity
A	0016830	molecular_function	carbon-carbon lyase activity
A	0016831	molecular_function	carboxy-lyase activity
A	0019752	biological_process	carboxylic acid metabolic process
A	0019899	molecular_function	enzyme binding
A	0030170	molecular_function	pyridoxal phosphate binding
A	0036467	molecular_function	5-hydroxy-L-tryptophan decarboxylase activity
A	0036468	molecular_function	L-dopa decarboxylase activity
A	0042416	biological_process	dopamine biosynthetic process
A	0042423	biological_process	catecholamine biosynthetic process
A	0042427	biological_process	serotonin biosynthetic process
A	0070062	cellular_component	extracellular exosome
B	0001822	biological_process	kidney development
B	0004058	molecular_function	aromatic-L-amino-acid decarboxylase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006520	biological_process	amino acid metabolic process
B	0006584	biological_process	catecholamine metabolic process
B	0009636	biological_process	response to toxic substance
B	0010467	biological_process	gene expression
B	0016829	molecular_function	lyase activity
B	0016830	molecular_function	carbon-carbon lyase activity
B	0016831	molecular_function	carboxy-lyase activity
B	0019752	biological_process	carboxylic acid metabolic process
B	0019899	molecular_function	enzyme binding
B	0030170	molecular_function	pyridoxal phosphate binding
B	0036467	molecular_function	5-hydroxy-L-tryptophan decarboxylase activity
B	0036468	molecular_function	L-dopa decarboxylase activity
B	0042416	biological_process	dopamine biosynthetic process
B	0042423	biological_process	catecholamine biosynthetic process
B	0042427	biological_process	serotonin biosynthetic process
B	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PLP A 481

Chain	Residue
A	SER147
A	LYS303
A	ALA148
A	SER149
A	HIS192
A	THR246
A	ASP271
A	ALA273
A	ASN300
A	HIS302

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site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 481

Chain	Residue
B	LYS303
B	TRP304

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site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 482

Chain	Residue
B	PRO282
B	ARG285

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Functional Information from PROSITE/UniProt

site_id	PS00392
Number of Residues	22
Details	DDC_GAD_HDC_YDC DDC / GAD / HDC / TyrDC pyridoxal-phosphate attachment site. SFnFnphKWLlVnFDCsaMWvK

Chain	Residue	Details
A	SER296-LYS317

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P80041

Chain	Residue	Details
A	THR82
A	HIS192
B	THR82
B	HIS192

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:22143761, ECO:0007744|PDB:3RCH

Chain	Residue	Details
A	ALA148
A	SER149
A	THR246
A	ASN300
B	ALA148
B	SER149
B	THR246
B	ASN300

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N-acetylmethionine => ECO:0000250|UniProtKB:P80041

Chain	Residue	Details
A	MET1
B	MET1

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000269|PubMed:22143761

Chain	Residue	Details
A	LYS303
B	LYS303

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