Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3RAN

CANINE GDP-RAN Q69L MUTANT

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000054	biological_process	ribosomal subunit export from nucleus
A	0000070	biological_process	mitotic sister chromatid segregation
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0003924	molecular_function	GTPase activity
A	0005049	molecular_function	nuclear export signal receptor activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005635	cellular_component	nuclear envelope
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006606	biological_process	protein import into nucleus
A	0006611	biological_process	protein export from nucleus
A	0006913	biological_process	nucleocytoplasmic transport
A	0015031	biological_process	protein transport
A	0016442	cellular_component	RISC complex
A	0016787	molecular_function	hydrolase activity
A	0032991	cellular_component	protein-containing complex
A	0035281	biological_process	pre-miRNA export from nucleus
A	0042470	cellular_component	melanosome
A	0046039	biological_process	GTP metabolic process
A	0046827	biological_process	positive regulation of protein export from nucleus
A	0046872	molecular_function	metal ion binding
A	0051301	biological_process	cell division
A	0061015	biological_process	snRNA import into nucleus
A	0070883	molecular_function	pre-miRNA binding
A	1905172	molecular_function	RISC complex binding
B	0000054	biological_process	ribosomal subunit export from nucleus
B	0000070	biological_process	mitotic sister chromatid segregation
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0003924	molecular_function	GTPase activity
B	0005049	molecular_function	nuclear export signal receptor activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005635	cellular_component	nuclear envelope
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006606	biological_process	protein import into nucleus
B	0006611	biological_process	protein export from nucleus
B	0006913	biological_process	nucleocytoplasmic transport
B	0015031	biological_process	protein transport
B	0016442	cellular_component	RISC complex
B	0016787	molecular_function	hydrolase activity
B	0032991	cellular_component	protein-containing complex
B	0035281	biological_process	pre-miRNA export from nucleus
B	0042470	cellular_component	melanosome
B	0046039	biological_process	GTP metabolic process
B	0046827	biological_process	positive regulation of protein export from nucleus
B	0046872	molecular_function	metal ion binding
B	0051301	biological_process	cell division
B	0061015	biological_process	snRNA import into nucleus
B	0070883	molecular_function	pre-miRNA binding
B	1905172	molecular_function	RISC complex binding
C	0000054	biological_process	ribosomal subunit export from nucleus
C	0000070	biological_process	mitotic sister chromatid segregation
C	0000166	molecular_function	nucleotide binding
C	0000287	molecular_function	magnesium ion binding
C	0003924	molecular_function	GTPase activity
C	0005049	molecular_function	nuclear export signal receptor activity
C	0005515	molecular_function	protein binding
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005635	cellular_component	nuclear envelope
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006606	biological_process	protein import into nucleus
C	0006611	biological_process	protein export from nucleus
C	0006913	biological_process	nucleocytoplasmic transport
C	0015031	biological_process	protein transport
C	0016442	cellular_component	RISC complex
C	0016787	molecular_function	hydrolase activity
C	0032991	cellular_component	protein-containing complex
C	0035281	biological_process	pre-miRNA export from nucleus
C	0042470	cellular_component	melanosome
C	0046039	biological_process	GTP metabolic process
C	0046827	biological_process	positive regulation of protein export from nucleus
C	0046872	molecular_function	metal ion binding
C	0051301	biological_process	cell division
C	0061015	biological_process	snRNA import into nucleus
C	0070883	molecular_function	pre-miRNA binding
C	1905172	molecular_function	RISC complex binding
D	0000054	biological_process	ribosomal subunit export from nucleus
D	0000070	biological_process	mitotic sister chromatid segregation
D	0000166	molecular_function	nucleotide binding
D	0000287	molecular_function	magnesium ion binding
D	0003924	molecular_function	GTPase activity
D	0005049	molecular_function	nuclear export signal receptor activity
D	0005515	molecular_function	protein binding
D	0005525	molecular_function	GTP binding
D	0005634	cellular_component	nucleus
D	0005635	cellular_component	nuclear envelope
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006606	biological_process	protein import into nucleus
D	0006611	biological_process	protein export from nucleus
D	0006913	biological_process	nucleocytoplasmic transport
D	0015031	biological_process	protein transport
D	0016442	cellular_component	RISC complex
D	0016787	molecular_function	hydrolase activity
D	0032991	cellular_component	protein-containing complex
D	0035281	biological_process	pre-miRNA export from nucleus
D	0042470	cellular_component	melanosome
D	0046039	biological_process	GTP metabolic process
D	0046827	biological_process	positive regulation of protein export from nucleus
D	0046872	molecular_function	metal ion binding
D	0051301	biological_process	cell division
D	0061015	biological_process	snRNA import into nucleus
D	0070883	molecular_function	pre-miRNA binding
D	1905172	molecular_function	RISC complex binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 700

Chain	Residue
A	THR24
A	GDP704
A	HOH705
A	HOH706
A	HOH707
A	HOH708

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 701

Chain	Residue
B	HOH707
B	HOH708
B	HOH709
B	THR24
B	GDP705
B	HOH706

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 702

Chain	Residue
C	THR24
C	GDP706
C	HOH707
C	HOH708
C	HOH709
C	HOH710

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 703

Chain	Residue
D	THR24
D	GDP707
D	HOH708
D	HOH709
D	HOH710
D	HOH711

site_id	AC5
Number of Residues	19
Details	BINDING SITE FOR RESIDUE GDP A 704

Chain	Residue
A	GLY20
A	THR21
A	GLY22
A	LYS23
A	THR24
A	THR25
A	ASN122
A	LYS123
A	ASP125
A	SER150
A	ALA151
A	LYS152
A	MG700
A	HOH705
A	HOH706
A	HOH708
A	HOH720
A	HOH749
C	LYS127

site_id	AC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE GDP B 705

Chain	Residue
B	GLY20
B	THR21
B	GLY22
B	LYS23
B	THR24
B	THR25
B	ASN122
B	LYS123
B	ASP125
B	SER150
B	ALA151
B	LYS152
B	MG701
B	HOH706
B	HOH707
B	HOH709

site_id	AC7
Number of Residues	17
Details	BINDING SITE FOR RESIDUE GDP C 706

Chain	Residue
A	HOH757
C	GLY20
C	THR21
C	GLY22
C	LYS23
C	THR24
C	THR25
C	ASN122
C	LYS123
C	ASP125
C	ALA151
C	LYS152
C	MG702
C	HOH707
C	HOH708
C	HOH710
C	HOH733

site_id	AC8
Number of Residues	18
Details	BINDING SITE FOR RESIDUE GDP D 707

Chain	Residue
B	ASP190
D	GLY20
D	THR21
D	GLY22
D	LYS23
D	THR24
D	THR25
D	ASN122
D	LYS123
D	ASP125
D	SER150
D	ALA151
D	LYS152
D	MG703
D	HOH708
D	HOH709
D	HOH711
D	HOH766

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	656
Details	Domain: {"description":"Small GTPase Ran-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	32
Details	Region: {"description":"Switch-I","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	64
Details	Region: {"description":"Switch-II","evidences":[{"source":"PROSITE-ProRule","id":"PRU00752","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15602554","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15864302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19965479","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9533885","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9878368","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BYU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WA5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BKU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3A6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3RAN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W3Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5BXQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	24
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15602554","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15864302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19965479","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1WA5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BKU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3A6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15602554","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15864302","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19965479","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1WA5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BKU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3W3Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Site: {"description":"Essential for GTP hydrolysis","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	16
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62827","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"UniProtKB","id":"P62826","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	LEU69

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
B	LEU69

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
C	LEU69

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
D	LEU69

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	GLY20

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
B	GLY20

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
C	GLY20

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
D	GLY20

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)