3RAN
CANINE GDP-RAN Q69L MUTANT
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000054 | biological_process | ribosomal subunit export from nucleus |
| A | 0000070 | biological_process | mitotic sister chromatid segregation |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005049 | molecular_function | nuclear export signal receptor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005635 | cellular_component | nuclear envelope |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006606 | biological_process | protein import into nucleus |
| A | 0006611 | biological_process | protein export from nucleus |
| A | 0006913 | biological_process | nucleocytoplasmic transport |
| A | 0015031 | biological_process | protein transport |
| A | 0016442 | cellular_component | RISC complex |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0035281 | biological_process | pre-miRNA export from nucleus |
| A | 0042470 | cellular_component | melanosome |
| A | 0046039 | biological_process | GTP metabolic process |
| A | 0046827 | biological_process | positive regulation of protein export from nucleus |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051301 | biological_process | cell division |
| A | 0061015 | biological_process | snRNA import into nucleus |
| A | 0070883 | molecular_function | pre-miRNA binding |
| A | 1905172 | molecular_function | RISC complex binding |
| B | 0000054 | biological_process | ribosomal subunit export from nucleus |
| B | 0000070 | biological_process | mitotic sister chromatid segregation |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005049 | molecular_function | nuclear export signal receptor activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005635 | cellular_component | nuclear envelope |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006606 | biological_process | protein import into nucleus |
| B | 0006611 | biological_process | protein export from nucleus |
| B | 0006913 | biological_process | nucleocytoplasmic transport |
| B | 0015031 | biological_process | protein transport |
| B | 0016442 | cellular_component | RISC complex |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0032991 | cellular_component | protein-containing complex |
| B | 0035281 | biological_process | pre-miRNA export from nucleus |
| B | 0042470 | cellular_component | melanosome |
| B | 0046039 | biological_process | GTP metabolic process |
| B | 0046827 | biological_process | positive regulation of protein export from nucleus |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051301 | biological_process | cell division |
| B | 0061015 | biological_process | snRNA import into nucleus |
| B | 0070883 | molecular_function | pre-miRNA binding |
| B | 1905172 | molecular_function | RISC complex binding |
| C | 0000054 | biological_process | ribosomal subunit export from nucleus |
| C | 0000070 | biological_process | mitotic sister chromatid segregation |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0003924 | molecular_function | GTPase activity |
| C | 0005049 | molecular_function | nuclear export signal receptor activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005525 | molecular_function | GTP binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005635 | cellular_component | nuclear envelope |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006606 | biological_process | protein import into nucleus |
| C | 0006611 | biological_process | protein export from nucleus |
| C | 0006913 | biological_process | nucleocytoplasmic transport |
| C | 0015031 | biological_process | protein transport |
| C | 0016442 | cellular_component | RISC complex |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0032991 | cellular_component | protein-containing complex |
| C | 0035281 | biological_process | pre-miRNA export from nucleus |
| C | 0042470 | cellular_component | melanosome |
| C | 0046039 | biological_process | GTP metabolic process |
| C | 0046827 | biological_process | positive regulation of protein export from nucleus |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0051301 | biological_process | cell division |
| C | 0061015 | biological_process | snRNA import into nucleus |
| C | 0070883 | molecular_function | pre-miRNA binding |
| C | 1905172 | molecular_function | RISC complex binding |
| D | 0000054 | biological_process | ribosomal subunit export from nucleus |
| D | 0000070 | biological_process | mitotic sister chromatid segregation |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0003924 | molecular_function | GTPase activity |
| D | 0005049 | molecular_function | nuclear export signal receptor activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005525 | molecular_function | GTP binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005635 | cellular_component | nuclear envelope |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006606 | biological_process | protein import into nucleus |
| D | 0006611 | biological_process | protein export from nucleus |
| D | 0006913 | biological_process | nucleocytoplasmic transport |
| D | 0015031 | biological_process | protein transport |
| D | 0016442 | cellular_component | RISC complex |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0032991 | cellular_component | protein-containing complex |
| D | 0035281 | biological_process | pre-miRNA export from nucleus |
| D | 0042470 | cellular_component | melanosome |
| D | 0046039 | biological_process | GTP metabolic process |
| D | 0046827 | biological_process | positive regulation of protein export from nucleus |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0051301 | biological_process | cell division |
| D | 0061015 | biological_process | snRNA import into nucleus |
| D | 0070883 | molecular_function | pre-miRNA binding |
| D | 1905172 | molecular_function | RISC complex binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 700 |
| Chain | Residue |
| A | THR24 |
| A | GDP704 |
| A | HOH705 |
| A | HOH706 |
| A | HOH707 |
| A | HOH708 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 701 |
| Chain | Residue |
| B | HOH707 |
| B | HOH708 |
| B | HOH709 |
| B | THR24 |
| B | GDP705 |
| B | HOH706 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 702 |
| Chain | Residue |
| C | THR24 |
| C | GDP706 |
| C | HOH707 |
| C | HOH708 |
| C | HOH709 |
| C | HOH710 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG D 703 |
| Chain | Residue |
| D | THR24 |
| D | GDP707 |
| D | HOH708 |
| D | HOH709 |
| D | HOH710 |
| D | HOH711 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE GDP A 704 |
| Chain | Residue |
| A | GLY20 |
| A | THR21 |
| A | GLY22 |
| A | LYS23 |
| A | THR24 |
| A | THR25 |
| A | ASN122 |
| A | LYS123 |
| A | ASP125 |
| A | SER150 |
| A | ALA151 |
| A | LYS152 |
| A | MG700 |
| A | HOH705 |
| A | HOH706 |
| A | HOH708 |
| A | HOH720 |
| A | HOH749 |
| C | LYS127 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE GDP B 705 |
| Chain | Residue |
| B | GLY20 |
| B | THR21 |
| B | GLY22 |
| B | LYS23 |
| B | THR24 |
| B | THR25 |
| B | ASN122 |
| B | LYS123 |
| B | ASP125 |
| B | SER150 |
| B | ALA151 |
| B | LYS152 |
| B | MG701 |
| B | HOH706 |
| B | HOH707 |
| B | HOH709 |
| site_id | AC7 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE GDP C 706 |
| Chain | Residue |
| A | HOH757 |
| C | GLY20 |
| C | THR21 |
| C | GLY22 |
| C | LYS23 |
| C | THR24 |
| C | THR25 |
| C | ASN122 |
| C | LYS123 |
| C | ASP125 |
| C | ALA151 |
| C | LYS152 |
| C | MG702 |
| C | HOH707 |
| C | HOH708 |
| C | HOH710 |
| C | HOH733 |
| site_id | AC8 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE GDP D 707 |
| Chain | Residue |
| B | ASP190 |
| D | GLY20 |
| D | THR21 |
| D | GLY22 |
| D | LYS23 |
| D | THR24 |
| D | THR25 |
| D | ASN122 |
| D | LYS123 |
| D | ASP125 |
| D | SER150 |
| D | ALA151 |
| D | LYS152 |
| D | MG703 |
| D | HOH708 |
| D | HOH709 |
| D | HOH711 |
| D | HOH766 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15602554, ECO:0000269|PubMed:15864302, ECO:0000269|PubMed:19965479, ECO:0000269|PubMed:9533885, ECO:0000269|PubMed:9878368, ECO:0007744|PDB:1BYU, ECO:0007744|PDB:1WA5, ECO:0007744|PDB:2BKU, ECO:0007744|PDB:3A6P, ECO:0007744|PDB:3RAN, ECO:0007744|PDB:3W3Z, ECO:0007744|PDB:5BXQ |
| Chain | Residue | Details |
| A | ASP18 | |
| D | ASP18 | |
| D | ASN122 | |
| D | SER150 | |
| A | ASN122 | |
| A | SER150 | |
| B | ASP18 | |
| B | ASN122 | |
| B | SER150 | |
| C | ASP18 | |
| C | ASN122 | |
| C | SER150 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15602554, ECO:0000269|PubMed:15864302, ECO:0000269|PubMed:19965479, ECO:0007744|PDB:1WA5, ECO:0007744|PDB:2BKU, ECO:0007744|PDB:3A6P, ECO:0007744|PDB:3W3Z |
| Chain | Residue | Details |
| A | GLU36 | |
| B | GLU36 | |
| C | GLU36 | |
| D | GLU36 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15602554, ECO:0000269|PubMed:15864302, ECO:0000269|PubMed:19965479, ECO:0007744|PDB:1WA5, ECO:0007744|PDB:2BKU, ECO:0007744|PDB:3W3Z |
| Chain | Residue | Details |
| A | GLY68 | |
| B | GLY68 | |
| C | GLY68 | |
| D | GLY68 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | SITE: Essential for GTP hydrolysis => ECO:0000250|UniProtKB:P62826 |
| Chain | Residue | Details |
| A | LEU69 | |
| B | LEU69 | |
| C | LEU69 | |
| D | LEU69 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P62826 |
| Chain | Residue | Details |
| A | ALA2 | |
| B | ALA2 | |
| C | ALA2 | |
| D | ALA2 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P62826 |
| Chain | Residue | Details |
| A | THR24 | |
| B | THR24 | |
| C | THR24 | |
| D | THR24 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 16 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P62826 |
| Chain | Residue | Details |
| A | LYS37 | |
| C | LYS60 | |
| C | LYS99 | |
| C | LYS134 | |
| D | LYS37 | |
| D | LYS60 | |
| D | LYS99 | |
| D | LYS134 | |
| A | LYS60 | |
| A | LYS99 | |
| A | LYS134 | |
| B | LYS37 | |
| B | LYS60 | |
| B | LYS99 | |
| B | LYS134 | |
| C | LYS37 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P62826 |
| Chain | Residue | Details |
| A | LYS71 | |
| B | LYS71 | |
| C | LYS71 | |
| D | LYS71 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P62827 |
| Chain | Residue | Details |
| A | LYS159 | |
| B | LYS159 | |
| C | LYS159 | |
| D | LYS159 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62826 |
| Chain | Residue | Details |
| A | LYS71 | |
| B | LYS71 | |
| C | LYS71 | |
| D | LYS71 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0000250|UniProtKB:P62826 |
| Chain | Residue | Details |
| A | LYS152 | |
| B | LYS152 | |
| C | LYS152 | |
| D | LYS152 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| A | LEU69 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| B | LEU69 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| C | LEU69 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| D | LEU69 |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| A | GLY20 |
| site_id | CSA6 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| B | GLY20 |
| site_id | CSA7 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| C | GLY20 |
| site_id | CSA8 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| D | GLY20 |
