Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3R90

Crystal structure of Malignant T cell-amplified sequence 1 protein

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000339	molecular_function	RNA cap binding
A	0001731	biological_process	formation of translation preinitiation complex
A	0002188	biological_process	translation reinitiation
A	0003723	molecular_function	RNA binding
A	0003743	molecular_function	translation initiation factor activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0006412	biological_process	translation
A	0006413	biological_process	translational initiation
A	0006417	biological_process	regulation of translation
A	0006974	biological_process	DNA damage response
A	0032790	biological_process	ribosome disassembly
A	0043024	molecular_function	ribosomal small subunit binding
A	0045183	molecular_function	translation factor activity, non-nucleic acid binding
A	0075522	biological_process	IRES-dependent viral translational initiation
B	0000339	molecular_function	RNA cap binding
B	0001731	biological_process	formation of translation preinitiation complex
B	0002188	biological_process	translation reinitiation
B	0003723	molecular_function	RNA binding
B	0003743	molecular_function	translation initiation factor activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0006412	biological_process	translation
B	0006413	biological_process	translational initiation
B	0006417	biological_process	regulation of translation
B	0006974	biological_process	DNA damage response
B	0032790	biological_process	ribosome disassembly
B	0043024	molecular_function	ribosomal small subunit binding
B	0045183	molecular_function	translation factor activity, non-nucleic acid binding
B	0075522	biological_process	IRES-dependent viral translational initiation
C	0000339	molecular_function	RNA cap binding
C	0001731	biological_process	formation of translation preinitiation complex
C	0002188	biological_process	translation reinitiation
C	0003723	molecular_function	RNA binding
C	0003743	molecular_function	translation initiation factor activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0006412	biological_process	translation
C	0006413	biological_process	translational initiation
C	0006417	biological_process	regulation of translation
C	0006974	biological_process	DNA damage response
C	0032790	biological_process	ribosome disassembly
C	0043024	molecular_function	ribosomal small subunit binding
C	0045183	molecular_function	translation factor activity, non-nucleic acid binding
C	0075522	biological_process	IRES-dependent viral translational initiation
D	0000339	molecular_function	RNA cap binding
D	0001731	biological_process	formation of translation preinitiation complex
D	0002188	biological_process	translation reinitiation
D	0003723	molecular_function	RNA binding
D	0003743	molecular_function	translation initiation factor activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0006412	biological_process	translation
D	0006413	biological_process	translational initiation
D	0006417	biological_process	regulation of translation
D	0006974	biological_process	DNA damage response
D	0032790	biological_process	ribosome disassembly
D	0043024	molecular_function	ribosomal small subunit binding
D	0045183	molecular_function	translation factor activity, non-nucleic acid binding
D	0075522	biological_process	IRES-dependent viral translational initiation
E	0000339	molecular_function	RNA cap binding
E	0001731	biological_process	formation of translation preinitiation complex
E	0002188	biological_process	translation reinitiation
E	0003723	molecular_function	RNA binding
E	0003743	molecular_function	translation initiation factor activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0006412	biological_process	translation
E	0006413	biological_process	translational initiation
E	0006417	biological_process	regulation of translation
E	0006974	biological_process	DNA damage response
E	0032790	biological_process	ribosome disassembly
E	0043024	molecular_function	ribosomal small subunit binding
E	0045183	molecular_function	translation factor activity, non-nucleic acid binding
E	0075522	biological_process	IRES-dependent viral translational initiation
F	0000339	molecular_function	RNA cap binding
F	0001731	biological_process	formation of translation preinitiation complex
F	0002188	biological_process	translation reinitiation
F	0003723	molecular_function	RNA binding
F	0003743	molecular_function	translation initiation factor activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0006412	biological_process	translation
F	0006413	biological_process	translational initiation
F	0006417	biological_process	regulation of translation
F	0006974	biological_process	DNA damage response
F	0032790	biological_process	ribosome disassembly
F	0043024	molecular_function	ribosomal small subunit binding
F	0045183	molecular_function	translation factor activity, non-nucleic acid binding
F	0075522	biological_process	IRES-dependent viral translational initiation
G	0000339	molecular_function	RNA cap binding
G	0001731	biological_process	formation of translation preinitiation complex
G	0002188	biological_process	translation reinitiation
G	0003723	molecular_function	RNA binding
G	0003743	molecular_function	translation initiation factor activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0006412	biological_process	translation
G	0006413	biological_process	translational initiation
G	0006417	biological_process	regulation of translation
G	0006974	biological_process	DNA damage response
G	0032790	biological_process	ribosome disassembly
G	0043024	molecular_function	ribosomal small subunit binding
G	0045183	molecular_function	translation factor activity, non-nucleic acid binding
G	0075522	biological_process	IRES-dependent viral translational initiation
H	0000339	molecular_function	RNA cap binding
H	0001731	biological_process	formation of translation preinitiation complex
H	0002188	biological_process	translation reinitiation
H	0003723	molecular_function	RNA binding
H	0003743	molecular_function	translation initiation factor activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0006412	biological_process	translation
H	0006413	biological_process	translational initiation
H	0006417	biological_process	regulation of translation
H	0006974	biological_process	DNA damage response
H	0032790	biological_process	ribosome disassembly
H	0043024	molecular_function	ribosomal small subunit binding
H	0045183	molecular_function	translation factor activity, non-nucleic acid binding
H	0075522	biological_process	IRES-dependent viral translational initiation
I	0000339	molecular_function	RNA cap binding
I	0001731	biological_process	formation of translation preinitiation complex
I	0002188	biological_process	translation reinitiation
I	0003723	molecular_function	RNA binding
I	0003743	molecular_function	translation initiation factor activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0006412	biological_process	translation
I	0006413	biological_process	translational initiation
I	0006417	biological_process	regulation of translation
I	0006974	biological_process	DNA damage response
I	0032790	biological_process	ribosome disassembly
I	0043024	molecular_function	ribosomal small subunit binding
I	0045183	molecular_function	translation factor activity, non-nucleic acid binding
I	0075522	biological_process	IRES-dependent viral translational initiation
J	0000339	molecular_function	RNA cap binding
J	0001731	biological_process	formation of translation preinitiation complex
J	0002188	biological_process	translation reinitiation
J	0003723	molecular_function	RNA binding
J	0003743	molecular_function	translation initiation factor activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0006412	biological_process	translation
J	0006413	biological_process	translational initiation
J	0006417	biological_process	regulation of translation
J	0006974	biological_process	DNA damage response
J	0032790	biological_process	ribosome disassembly
J	0043024	molecular_function	ribosomal small subunit binding
J	0045183	molecular_function	translation factor activity, non-nucleic acid binding
J	0075522	biological_process	IRES-dependent viral translational initiation
K	0000339	molecular_function	RNA cap binding
K	0001731	biological_process	formation of translation preinitiation complex
K	0002188	biological_process	translation reinitiation
K	0003723	molecular_function	RNA binding
K	0003743	molecular_function	translation initiation factor activity
K	0005515	molecular_function	protein binding
K	0005737	cellular_component	cytoplasm
K	0006412	biological_process	translation
K	0006413	biological_process	translational initiation
K	0006417	biological_process	regulation of translation
K	0006974	biological_process	DNA damage response
K	0032790	biological_process	ribosome disassembly
K	0043024	molecular_function	ribosomal small subunit binding
K	0045183	molecular_function	translation factor activity, non-nucleic acid binding
K	0075522	biological_process	IRES-dependent viral translational initiation
L	0000339	molecular_function	RNA cap binding
L	0001731	biological_process	formation of translation preinitiation complex
L	0002188	biological_process	translation reinitiation
L	0003723	molecular_function	RNA binding
L	0003743	molecular_function	translation initiation factor activity
L	0005515	molecular_function	protein binding
L	0005737	cellular_component	cytoplasm
L	0006412	biological_process	translation
L	0006413	biological_process	translational initiation
L	0006417	biological_process	regulation of translation
L	0006974	biological_process	DNA damage response
L	0032790	biological_process	ribosome disassembly
L	0043024	molecular_function	ribosomal small subunit binding
L	0045183	molecular_function	translation factor activity, non-nucleic acid binding
L	0075522	biological_process	IRES-dependent viral translational initiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 189

Chain	Residue
A	MET1
A	PHE2
A	LYS3
A	HOH526

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 190

Chain	Residue
G	HOH496
A	LYS3
A	SER107
A	HOH567
G	ARG83
G	LYS178

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 191

Chain	Residue
A	ARG83
A	LYS178
A	HOH529
G	LYS3
G	SER107
H	GLN42

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 189

Chain	Residue
B	ARG83
B	LYS178
B	HOH550
B	HOH1089
G	GLN42
L	LYS3
L	SER107

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 190

Chain	Residue
B	MET1
B	PHE2
B	LYS3
B	HOH953
B	HOH1248

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 189

Chain	Residue
B	LYS3
B	SER107
B	HOH929
C	TRP39
C	GLN42
L	ARG83
L	LYS178

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 190

Chain	Residue
C	ARG83
C	LYS178
C	HOH1190
K	LYS3
K	SER107
L	TRP39
L	GLN42

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 D 189

Chain	Residue
D	ARG83
D	TRP175
D	LYS178
J	LYS3
J	SER107
J	HOH609
K	GLN42
K	HOH1257

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 190

Chain	Residue
D	MET1
D	PHE2
D	LYS3
D	HOH878
D	HOH967

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 189

Chain	Residue
E	MET1
E	PHE2
E	LYS3
E	HOH728

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 E 190

Chain	Residue
E	ARG83
E	LYS178
E	HOH1123
I	LYS3
I	SER107
I	HOH625
J	GLN42

site_id	BC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 F 189

Chain	Residue
F	ARG83
F	TRP175
F	LYS178
F	HOH346
F	HOH1417
F	HOH1420
H	LYS3
H	SER107
I	TRP39
I	GLN42

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 F 190

Chain	Residue
F	MET1
F	PHE2
F	LYS3
F	HOH211
F	HOH403
F	HOH1031

site_id	BC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 F 191

Chain	Residue
E	LYS3
E	SER107
F	TRP39
F	GLN42
F	HOH486
I	ARG83
I	LYS178

site_id	BC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 G 189

Chain	Residue
G	MET1
G	PHE2
G	LYS3
G	HOH427
G	HOH489
G	HOH683
G	HOH1072
G	HOH1073

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 H 189

Chain	Residue
H	LYS3
H	HOH316
H	HOH580
H	MET1
H	PHE2

site_id	BC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 H 190

Chain	Residue
A	GLN42
F	LYS3
F	SER107
F	HOH199
H	ARG83
H	LYS178
H	HOH395

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 I 189

Chain	Residue
I	MET1
I	PHE2
I	LYS3
I	HOH472
I	HOH1259

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 J 189

Chain	Residue
J	MET1
J	PHE2
J	LYS3
J	HOH483
J	HOH1006

site_id	CC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 J 190

Chain	Residue
D	LYS3
D	HOH971
E	TRP39
E	GLN42
J	ARG83
J	LYS178
J	HOH970

site_id	CC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 K 189

Chain	Residue
K	MET1
K	PHE2
K	LYS3
K	HOH385
K	HOH397
K	HOH819
K	HOH1167

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 K 190

Chain	Residue
H	LYS18
K	ILE15
K	ARG54
K	HOH307

site_id	CC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 K 191

Chain	Residue
C	LYS3
C	SER107
D	TRP39
D	GLN42
K	ARG83
K	TRP175
K	LYS178
K	HOH1269

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 L 189

Chain	Residue
C	LYS87
L	GLU67
L	ARG83
L	LYS87
L	LYS178
L	HOH714

site_id	CC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 L 190

Chain	Residue
L	MET1
L	PHE2
L	LYS3
L	HOH750
L	HOH1212
L	HOH1272
L	HOH1274

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL L 191

Chain	Residue
F	ILE25
F	ILE52
F	ARG72
F	HOH422
L	ASP154
L	HOH652

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	MOD_RES: Phosphothreonine; by MAPK1 and MAPK3 => ECO:0000269\|PubMed:17016429

Chain	Residue	Details
A	THR81
J	THR81
K	THR81
L	THR81
B	THR81
C	THR81
D	THR81
E	THR81
F	THR81
G	THR81
H	THR81
I	THR81

site_id	SWS_FT_FI2
Number of Residues	12
Details	MOD_RES: Phosphoserine; by CDK1 => ECO:0000269\|PubMed:17016429

Chain	Residue	Details
A	SER118
J	SER118
K	SER118
L	SER118
B	SER118
C	SER118
D	SER118
E	SER118
F	SER118
G	SER118
H	SER118
I	SER118

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)