Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3R6S

Crystal structure of GlxR transcription factor from Corynebacterium glutamicum with cAMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0001216	molecular_function	DNA-binding transcription activator activity
A	0001217	molecular_function	DNA-binding transcription repressor activity
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005829	cellular_component	cytosol
A	0006355	biological_process	regulation of DNA-templated transcription
A	0016301	molecular_function	kinase activity
A	0030552	molecular_function	cAMP binding
A	0032993	cellular_component	protein-DNA complex
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	2000874	biological_process	regulation of glyoxylate cycle
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0001216	molecular_function	DNA-binding transcription activator activity
B	0001217	molecular_function	DNA-binding transcription repressor activity
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005829	cellular_component	cytosol
B	0006355	biological_process	regulation of DNA-templated transcription
B	0016301	molecular_function	kinase activity
B	0030552	molecular_function	cAMP binding
B	0032993	cellular_component	protein-DNA complex
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	2000874	biological_process	regulation of glyoxylate cycle
C	0000976	molecular_function	transcription cis-regulatory region binding
C	0001216	molecular_function	DNA-binding transcription activator activity
C	0001217	molecular_function	DNA-binding transcription repressor activity
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0005829	cellular_component	cytosol
C	0006355	biological_process	regulation of DNA-templated transcription
C	0016301	molecular_function	kinase activity
C	0030552	molecular_function	cAMP binding
C	0032993	cellular_component	protein-DNA complex
C	0045892	biological_process	negative regulation of DNA-templated transcription
C	0045893	biological_process	positive regulation of DNA-templated transcription
C	2000874	biological_process	regulation of glyoxylate cycle
D	0000976	molecular_function	transcription cis-regulatory region binding
D	0001216	molecular_function	DNA-binding transcription activator activity
D	0001217	molecular_function	DNA-binding transcription repressor activity
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0005829	cellular_component	cytosol
D	0006355	biological_process	regulation of DNA-templated transcription
D	0016301	molecular_function	kinase activity
D	0030552	molecular_function	cAMP binding
D	0032993	cellular_component	protein-DNA complex
D	0045892	biological_process	negative regulation of DNA-templated transcription
D	0045893	biological_process	positive regulation of DNA-templated transcription
D	2000874	biological_process	regulation of glyoxylate cycle
E	0000976	molecular_function	transcription cis-regulatory region binding
E	0001216	molecular_function	DNA-binding transcription activator activity
E	0001217	molecular_function	DNA-binding transcription repressor activity
E	0003677	molecular_function	DNA binding
E	0003700	molecular_function	DNA-binding transcription factor activity
E	0005829	cellular_component	cytosol
E	0006355	biological_process	regulation of DNA-templated transcription
E	0016301	molecular_function	kinase activity
E	0030552	molecular_function	cAMP binding
E	0032993	cellular_component	protein-DNA complex
E	0045892	biological_process	negative regulation of DNA-templated transcription
E	0045893	biological_process	positive regulation of DNA-templated transcription
E	2000874	biological_process	regulation of glyoxylate cycle
F	0000976	molecular_function	transcription cis-regulatory region binding
F	0001216	molecular_function	DNA-binding transcription activator activity
F	0001217	molecular_function	DNA-binding transcription repressor activity
F	0003677	molecular_function	DNA binding
F	0003700	molecular_function	DNA-binding transcription factor activity
F	0005829	cellular_component	cytosol
F	0006355	biological_process	regulation of DNA-templated transcription
F	0016301	molecular_function	kinase activity
F	0030552	molecular_function	cAMP binding
F	0032993	cellular_component	protein-DNA complex
F	0045892	biological_process	negative regulation of DNA-templated transcription
F	0045893	biological_process	positive regulation of DNA-templated transcription
F	2000874	biological_process	regulation of glyoxylate cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE CMP A 301

Chain	Residue
A	PHE41
A	ARG92
A	THR93
A	SER94
A	ARG133
A	THR137
C	ASN138
A	LEU60
A	LEU72
A	MET75
A	PHE81
A	GLY82
A	GLU83
A	LEU84
A	SER85

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE HEZ A 228

Chain	Residue
A	ARG33
A	PHE34
A	TYR51
E	TYR51
E	THR106

site_id	AC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE CMP B 301

Chain	Residue
B	PHE41
B	LEU72
B	MET75
B	PHE81
B	GLY82
B	GLU83
B	LEU84
B	SER85
B	ARG92
B	THR93
B	SER94
B	ARG133
B	LEU134
B	THR137
B	ASN138
B	HOH237

site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE CMP C 301

Chain	Residue
A	LEU134
A	ASN138
C	PHE41
C	LEU60
C	LEU72
C	PHE81
C	GLY82
C	GLU83
C	LEU84
C	SER85
C	ARG92
C	THR93
C	SER94
C	ARG133
C	THR137

site_id	AC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE CMP D 301

Chain	Residue
D	PHE41
D	LEU60
D	LEU72
D	PHE81
D	GLY82
D	GLU83
D	LEU84
D	SER85
D	ARG92
D	THR93
D	SER94
D	ARG133
D	THR137
E	ASN138

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE HEZ D 228

Chain	Residue
C	ARG49
C	TYR51
D	ARG49
D	TYR51

site_id	AC7
Number of Residues	14
Details	BINDING SITE FOR RESIDUE CMP E 301

Chain	Residue
D	ASN138
E	PHE41
E	LEU60
E	MET75
E	PHE81
E	GLY82
E	GLU83
E	LEU84
E	SER85
E	ARG92
E	THR93
E	SER94
E	ARG133
E	HOH247

site_id	AC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CMP F 301

Chain	Residue
F	LEU60
F	LEU72
F	PHE81
F	GLY82
F	GLU83
F	LEU84
F	SER85
F	ARG92
F	THR93
F	SER94
F	ARG133
F	ASN138

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE HEZ F 228

Chain	Residue
F	THR106
F	HOH241
B	PHE34
B	TYR51
F	ARG49
F	TYR51

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	114
Details	DNA_BIND: H-T-H motif => ECO:0000255\|PROSITE-ProRule:PRU00387

Chain	Residue	Details
A	GLN180-ALA199
B	GLN180-ALA199
C	GLN180-ALA199
D	GLN180-ALA199
E	GLN180-ALA199
F	GLN180-ALA199

site_id	SWS_FT_FI2
Number of Residues	18
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P0ACJ8

Chain	Residue	Details
C	GLY67
A	ILE145
A	GLY67
A	GLU181
B	GLY67
B	ILE145
B	GLU181
C	ILE145
C	GLU181
D	GLY67
D	ILE145
D	GLU181
E	GLY67
E	ILE145
E	GLU181
F	GLY67
F	ILE145
F	GLU181

site_id	SWS_FT_FI3
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269\|Ref.7

Chain	Residue	Details
A	GLY82
B	GLY82
A	ARG92
E	GLY82
E	ARG92
E	THR137
F	GLY82
F	ARG92
F	THR137
A	THR137
B	ARG92
B	THR137
C	GLY82
C	ARG92
C	THR137
D	GLY82
D	ARG92
D	THR137

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)