Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3R3I

Crystal Structure of C-terminal truncation of UDP-glucose Pyrophosphorylase of Homo sapiens

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003983	molecular_function	UTP:glucose-1-phosphate uridylyltransferase activity
A	0005515	molecular_function	protein binding
A	0005536	molecular_function	glucose binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005977	biological_process	glycogen metabolic process
A	0005978	biological_process	glycogen biosynthetic process
A	0006011	biological_process	UDP-glucose metabolic process
A	0007420	biological_process	brain development
A	0016779	molecular_function	nucleotidyltransferase activity
A	0019255	biological_process	glucose 1-phosphate metabolic process
A	0032557	molecular_function	pyrimidine ribonucleotide binding
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0051748	molecular_function	UTP-monosaccharide-1-phosphate uridylyltransferase activity
A	0070062	cellular_component	extracellular exosome
A	0070569	molecular_function	uridylyltransferase activity
B	0003983	molecular_function	UTP:glucose-1-phosphate uridylyltransferase activity
B	0005515	molecular_function	protein binding
B	0005536	molecular_function	glucose binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005977	biological_process	glycogen metabolic process
B	0005978	biological_process	glycogen biosynthetic process
B	0006011	biological_process	UDP-glucose metabolic process
B	0007420	biological_process	brain development
B	0016779	molecular_function	nucleotidyltransferase activity
B	0019255	biological_process	glucose 1-phosphate metabolic process
B	0032557	molecular_function	pyrimidine ribonucleotide binding
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0051748	molecular_function	UTP-monosaccharide-1-phosphate uridylyltransferase activity
B	0070062	cellular_component	extracellular exosome
B	0070569	molecular_function	uridylyltransferase activity
C	0003983	molecular_function	UTP:glucose-1-phosphate uridylyltransferase activity
C	0005515	molecular_function	protein binding
C	0005536	molecular_function	glucose binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005977	biological_process	glycogen metabolic process
C	0005978	biological_process	glycogen biosynthetic process
C	0006011	biological_process	UDP-glucose metabolic process
C	0007420	biological_process	brain development
C	0016779	molecular_function	nucleotidyltransferase activity
C	0019255	biological_process	glucose 1-phosphate metabolic process
C	0032557	molecular_function	pyrimidine ribonucleotide binding
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0051748	molecular_function	UTP-monosaccharide-1-phosphate uridylyltransferase activity
C	0070062	cellular_component	extracellular exosome
C	0070569	molecular_function	uridylyltransferase activity
D	0003983	molecular_function	UTP:glucose-1-phosphate uridylyltransferase activity
D	0005515	molecular_function	protein binding
D	0005536	molecular_function	glucose binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005977	biological_process	glycogen metabolic process
D	0005978	biological_process	glycogen biosynthetic process
D	0006011	biological_process	UDP-glucose metabolic process
D	0007420	biological_process	brain development
D	0016779	molecular_function	nucleotidyltransferase activity
D	0019255	biological_process	glucose 1-phosphate metabolic process
D	0032557	molecular_function	pyrimidine ribonucleotide binding
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0051748	molecular_function	UTP-monosaccharide-1-phosphate uridylyltransferase activity
D	0070062	cellular_component	extracellular exosome
D	0070569	molecular_function	uridylyltransferase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: ACT_SITE => ECO:0000250

Chain	Residue	Details
A	LYS385
B	LYS385
C	LYS385
D	LYS385

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q9M9P3

Chain	Residue	Details
A	LEU102
B	GLY211
B	ASP242
B	LYS385
C	LEU102
C	LYS116
C	GLN179
C	GLY211
C	ASP242
C	LYS385
D	LEU102
A	LYS116
D	LYS116
D	GLN179
D	GLY211
D	ASP242
D	LYS385
A	GLN179
A	GLY211
A	ASP242
A	LYS385
B	LEU102
B	LYS116
B	GLN179

site_id	SWS_FT_FI3
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:25860585, ECO:0007744\|PDB:4R7P

Chain	Residue	Details
A	GLY104
C	HIS212
C	ASN240
C	ASN319
D	GLY104
D	HIS212
D	ASN240
D	ASN319
A	HIS212
A	ASN240
A	ASN319
B	GLY104
B	HIS212
B	ASN240
B	ASN319
C	GLY104

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:21406692, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER2
B	SER2
C	SER2
D	SER2

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphothreonine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	THR415
B	THR415
C	THR415
D	THR415

site_id	SWS_FT_FI6
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:24275569

Chain	Residue	Details
A	SER423
D	SER423
D	SER437
D	SER450
A	SER437
A	SER450
B	SER423
B	SER437
B	SER450
C	SER423
C	SER437
C	SER450

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS427
B	LYS427
C	LYS427
D	LYS427

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)