3R2W

Crystal Structure of UDP-glucose Pyrophosphorylase of Homo Sapiens

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003983	molecular_function	UTP:glucose-1-phosphate uridylyltransferase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005977	biological_process	glycogen metabolic process
A	0005978	biological_process	glycogen biosynthetic process
A	0006011	biological_process	UDP-alpha-D-glucose metabolic process
A	0007420	biological_process	brain development
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0051748	molecular_function	UTP-monosaccharide-1-phosphate uridylyltransferase activity
A	0070062	cellular_component	extracellular exosome
A	0070569	molecular_function	uridylyltransferase activity
B	0003983	molecular_function	UTP:glucose-1-phosphate uridylyltransferase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005977	biological_process	glycogen metabolic process
B	0005978	biological_process	glycogen biosynthetic process
B	0006011	biological_process	UDP-alpha-D-glucose metabolic process
B	0007420	biological_process	brain development
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0051748	molecular_function	UTP-monosaccharide-1-phosphate uridylyltransferase activity
B	0070062	cellular_component	extracellular exosome
B	0070569	molecular_function	uridylyltransferase activity
C	0003983	molecular_function	UTP:glucose-1-phosphate uridylyltransferase activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005977	biological_process	glycogen metabolic process
C	0005978	biological_process	glycogen biosynthetic process
C	0006011	biological_process	UDP-alpha-D-glucose metabolic process
C	0007420	biological_process	brain development
C	0016740	molecular_function	transferase activity
C	0016779	molecular_function	nucleotidyltransferase activity
C	0042802	molecular_function	identical protein binding
C	0046872	molecular_function	metal ion binding
C	0051748	molecular_function	UTP-monosaccharide-1-phosphate uridylyltransferase activity
C	0070062	cellular_component	extracellular exosome
C	0070569	molecular_function	uridylyltransferase activity
D	0003983	molecular_function	UTP:glucose-1-phosphate uridylyltransferase activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005977	biological_process	glycogen metabolic process
D	0005978	biological_process	glycogen biosynthetic process
D	0006011	biological_process	UDP-alpha-D-glucose metabolic process
D	0007420	biological_process	brain development
D	0016740	molecular_function	transferase activity
D	0016779	molecular_function	nucleotidyltransferase activity
D	0042802	molecular_function	identical protein binding
D	0046872	molecular_function	metal ion binding
D	0051748	molecular_function	UTP-monosaccharide-1-phosphate uridylyltransferase activity
D	0070062	cellular_component	extracellular exosome
D	0070569	molecular_function	uridylyltransferase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	204
Details	Region: {"description":"Oligomerization"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Region: {"description":"Critical for end-to-end subunit interaction"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9M9P3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25860585","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4R7P","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---