3R0F
Human enterovirus 71 3C protease mutant H133G in complex with rupintrivir
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019028 | cellular_component | viral capsid |
| A | 0019062 | biological_process | virion attachment to host cell |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0039618 | cellular_component | T=pseudo3 icosahedral viral capsid |
| A | 0044423 | cellular_component | virion component |
| A | 0046718 | biological_process | symbiont entry into host cell |
| B | 0003723 | molecular_function | RNA binding |
| B | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008234 | molecular_function | cysteine-type peptidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019028 | cellular_component | viral capsid |
| B | 0019062 | biological_process | virion attachment to host cell |
| B | 0030430 | cellular_component | host cell cytoplasm |
| B | 0039618 | cellular_component | T=pseudo3 icosahedral viral capsid |
| B | 0044423 | cellular_component | virion component |
| B | 0046718 | biological_process | symbiont entry into host cell |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE AG7 A 501 |
| Chain | Residue |
| A | ARG39 |
| A | LYS143 |
| A | ALA144 |
| A | GLY145 |
| A | CYS147 |
| A | HIS161 |
| A | ILE162 |
| A | GLY163 |
| A | GLY164 |
| A | ASN165 |
| A | PHE170 |
| A | HIS40 |
| A | EDO185 |
| A | HOH316 |
| A | GLU71 |
| A | LEU125 |
| A | ASN126 |
| A | LEU127 |
| A | SER128 |
| A | LYS130 |
| A | THR142 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 184 |
| Chain | Residue |
| A | GLN17 |
| A | TRP48 |
| A | GLU50 |
| A | HIS51 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 185 |
| Chain | Residue |
| A | GLN22 |
| A | GLY23 |
| A | HIS24 |
| A | GLY145 |
| A | HOH203 |
| A | AG7501 |
| site_id | AC4 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE AG7 B 501 |
| Chain | Residue |
| A | LEU53 |
| A | HOH257 |
| B | ARG39 |
| B | HIS40 |
| B | GLU71 |
| B | ASN126 |
| B | LEU127 |
| B | SER128 |
| B | LYS130 |
| B | THR142 |
| B | LYS143 |
| B | ALA144 |
| B | GLY145 |
| B | CYS147 |
| B | HIS161 |
| B | ILE162 |
| B | GLY163 |
| B | GLY164 |
| B | ASN165 |
| B | PHE170 |
| B | EDO185 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 184 |
| Chain | Residue |
| B | GLN17 |
| B | TRP48 |
| B | GLU50 |
| B | HIS51 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO B 185 |
| Chain | Residue |
| B | GLN22 |
| B | GLY23 |
| B | HIS24 |
| B | GLY145 |
| B | HOH197 |
| B | HOH247 |
| B | AG7501 |
