3QZS

Crystal Structure of BPTF bromo in complex with histone H4K16ac - Form I

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0016589	cellular_component	NURF complex
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0016589	cellular_component	NURF complex

Functional Information from PROSITE/UniProt

site_id	PS00047
Number of Residues	5
Details	HISTONE_H4 Histone H4 signature. GAKRH

Chain	Residue	Details
C	GLY14-HIS18

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site_id	PS00633
Number of Residues	58
Details	BROMODOMAIN_1 Bromodomain signature. AwpFlepvDpndap..DYYgvIkepMdlatMeervqrry..Yekltefvadmta.IfdNCryY

Chain	Residue	Details
A	ALA90-TYR147

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	DNA_BIND:

Chain	Residue	Details
C	ALY16-LYS20
D	ALY16-LYS20

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435

Chain	Residue	Details
C	LYS12
D	LYS12

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-propionyllysine; alternate => ECO:0000269|PubMed:17267393

Chain	Residue	Details
C	ALY16
D	ALY16

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:12086618, ECO:0000269|PubMed:15964846, ECO:0000269|PubMed:17967882, ECO:0000269|PubMed:27338793

Chain	Residue	Details
C	LYS20
D	LYS20

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site_id	SWS_FT_FI5
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447

Chain	Residue	Details
C	LYS12
D	LYS12

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site_id	SWS_FT_FI6
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733

Chain	Residue	Details
C	LYS20
D	LYS20

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