3QY9
The Crystal Structure of Dihydrodipicolinate reductase from Staphylococcus aureus
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0008839 | molecular_function | 4-hydroxy-tetrahydrodipicolinate reductase |
| A | 0009085 | biological_process | lysine biosynthetic process |
| A | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016726 | molecular_function | oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor |
| A | 0019877 | biological_process | diaminopimelate biosynthetic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0050661 | molecular_function | NADP binding |
| A | 0051287 | molecular_function | NAD binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0008839 | molecular_function | 4-hydroxy-tetrahydrodipicolinate reductase |
| B | 0009085 | biological_process | lysine biosynthetic process |
| B | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016726 | molecular_function | oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor |
| B | 0019877 | biological_process | diaminopimelate biosynthetic process |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0050661 | molecular_function | NADP binding |
| B | 0051287 | molecular_function | NAD binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0008839 | molecular_function | 4-hydroxy-tetrahydrodipicolinate reductase |
| C | 0009085 | biological_process | lysine biosynthetic process |
| C | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016726 | molecular_function | oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor |
| C | 0019877 | biological_process | diaminopimelate biosynthetic process |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0050661 | molecular_function | NADP binding |
| C | 0051287 | molecular_function | NAD binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0008839 | molecular_function | 4-hydroxy-tetrahydrodipicolinate reductase |
| D | 0009085 | biological_process | lysine biosynthetic process |
| D | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016726 | molecular_function | oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor |
| D | 0019877 | biological_process | diaminopimelate biosynthetic process |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0050661 | molecular_function | NADP binding |
| D | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 241 |
| Chain | Residue |
| A | HIS136 |
| A | LYS213 |
| A | SO4243 |
| A | HOH273 |
| A | HOH423 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 242 |
| Chain | Residue |
| A | HOH268 |
| A | HOH308 |
| A | HOH505 |
| A | HOH699 |
| A | LYS139 |
| A | SER144 |
| A | GLY145 |
| A | THR146 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 243 |
| Chain | Residue |
| A | LYS139 |
| A | VAL140 |
| A | ASP141 |
| A | SO4241 |
| A | HOH423 |
| A | HOH601 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 244 |
| Chain | Residue |
| A | ALA10 |
| A | ARG14 |
| A | LYS213 |
| A | HOH508 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 245 |
| Chain | Residue |
| A | ARG14 |
| A | SER212 |
| A | LYS213 |
| A | HOH269 |
| A | HOH590 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE ACT B 241 |
| Chain | Residue |
| B | LYS138 |
| B | LYS139 |
| B | VAL140 |
| B | ASP141 |
| B | SO4245 |
| B | HOH279 |
| D | HOH303 |
| D | HOH304 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 242 |
| Chain | Residue |
| B | ARG14 |
| B | HOH257 |
| B | HOH259 |
| C | HOH284 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 243 |
| Chain | Residue |
| B | ALA10 |
| B | ARG14 |
| B | LYS213 |
| B | HOH304 |
| B | HOH305 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 244 |
| Chain | Residue |
| B | VAL164 |
| B | TYR165 |
| B | ASP166 |
| B | LEU170 |
| B | HOH478 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 B 245 |
| Chain | Residue |
| B | HIS136 |
| B | LYS139 |
| B | LYS213 |
| B | ACT241 |
| B | HOH275 |
| B | HOH279 |
| site_id | BC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 246 |
| Chain | Residue |
| B | SER103 |
| B | ALA104 |
| B | ASN105 |
| B | HIS111 |
| B | LYS149 |
| B | PHE237 |
| B | HOH341 |
| B | HOH351 |
| B | HOH443 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 247 |
| Chain | Residue |
| B | THR162 |
| B | GLN177 |
| B | HOH283 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 C 241 |
| Chain | Residue |
| B | HOH257 |
| C | ARG14 |
| C | SER212 |
| C | HOH260 |
| C | HOH262 |
| C | HOH284 |
| C | HOH542 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 248 |
| Chain | Residue |
| B | THR81 |
| B | LYS139 |
| B | SER144 |
| B | GLY145 |
| B | THR146 |
| B | HOH277 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 242 |
| Chain | Residue |
| C | LYS139 |
| C | SER144 |
| C | GLY145 |
| C | THR146 |
| C | HOH310 |
| C | HOH486 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 243 |
| Chain | Residue |
| C | LYS139 |
| C | VAL140 |
| C | ASP141 |
| C | SO4244 |
| C | HOH339 |
| C | HOH598 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 C 244 |
| Chain | Residue |
| C | HIS136 |
| C | LYS213 |
| C | SO4243 |
| C | HOH313 |
| C | HOH339 |
| C | HOH688 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 245 |
| Chain | Residue |
| C | ARG14 |
| C | LYS213 |
| C | HOH330 |
| C | HOH627 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 246 |
| Chain | Residue |
| C | GLY9 |
| C | ALA10 |
| C | HOH338 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT D 241 |
| Chain | Residue |
| D | SER59 |
| D | ASN60 |
| D | PRO61 |
| D | THR80 |
| D | HOH321 |
| site_id | CC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 242 |
| Chain | Residue |
| D | LYS139 |
| D | SER144 |
| D | GLY145 |
| D | THR146 |
| D | HOH257 |
| D | HOH300 |
| site_id | CC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 D 243 |
| Chain | Residue |
| D | HIS136 |
| D | LYS139 |
| D | LYS213 |
| D | SO4245 |
| D | HOH316 |
| D | HOH502 |
| site_id | CC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 244 |
| Chain | Residue |
| D | ARG14 |
| D | LYS213 |
| D | HOH342 |
| D | HOH343 |
| site_id | CC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 245 |
| Chain | Residue |
| D | LYS139 |
| D | VAL140 |
| D | ASP141 |
| D | SO4243 |
| D | HOH502 |
| site_id | CC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 246 |
| Chain | Residue |
| D | GLY9 |
| D | ALA10 |
| D | HOH348 |
| site_id | CC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 D 247 |
| Chain | Residue |
| B | ARG226 |
| B | LYS230 |
| D | ASN97 |
| D | ASN232 |
| D | HOH271 |
| D | HOH621 |
| D | HOH689 |
Functional Information from PROSITE/UniProt
| site_id | PS01298 |
| Number of Residues | 18 |
| Details | DAPB Dihydrodipicolinate reductase signature. ELtEaHhnkKvDapSGTL |
| Chain | Residue | Details |
| A | GLU130-LEU147 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00102","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"HAMAP-Rule","id":"MF_00102","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 28 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00102","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
