3QPW
PFKFB3 in complex with Aluminum Tetrafluoride
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003873 | molecular_function | 6-phosphofructo-2-kinase activity |
| A | 0004331 | molecular_function | fructose-2,6-bisphosphate 2-phosphatase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006000 | biological_process | fructose metabolic process |
| A | 0006003 | biological_process | fructose 2,6-bisphosphate metabolic process |
| A | 0006094 | biological_process | gluconeogenesis |
| A | 0006096 | biological_process | glycolytic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0046835 | biological_process | carbohydrate phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE ALF A 762 |
| Chain | Residue |
| A | ARG252 |
| A | HIS253 |
| A | ASN256 |
| A | ASN259 |
| A | GLU322 |
| A | HIS387 |
| A | GLN388 |
| A | HOH608 |
| A | HOH666 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE ADP A 800 |
| Chain | Residue |
| A | LEU42 |
| A | PRO43 |
| A | ALA44 |
| A | ARG45 |
| A | GLY46 |
| A | LYS47 |
| A | THR48 |
| A | TYR49 |
| A | SER152 |
| A | ASN163 |
| A | GLU166 |
| A | VAL167 |
| A | LYS168 |
| A | VAL214 |
| A | VAL243 |
| A | TYR424 |
| A | HOH714 |
| A | HOH754 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PEP A 801 |
| Chain | Residue |
| A | GLY71 |
| A | ARG74 |
| A | PHE87 |
| A | ARG98 |
| A | ALA125 |
| A | THR126 |
| A | TYR193 |
| A | HOH554 |
| A | HOH585 |
| A | HOH603 |
| A | HOH697 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 520 |
| Chain | Residue |
| A | PHE87 |
| A | ARG98 |
| A | HOH731 |
Functional Information from PROSITE/UniProt
| site_id | PS00175 |
| Number of Residues | 10 |
| Details | PG_MUTASE Phosphoglycerate mutase family phosphohistidine signature. LcRHGEnEhN |
| Chain | Residue | Details |
| A | LEU250-ASN259 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Tele-phosphohistidine intermediate","evidences":[{"source":"PubMed","id":"22275052","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"22275052","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16316985","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17499765","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22275052","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16316985","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25849762","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P07953","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"22275052","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
