3QOW

DOT1L Structure in complex with SAM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0031151	molecular_function	histone H3K79 methyltransferase activity
A	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE SAM A 417

Chain	Residue
A	PRO133
A	VAL169
A	GLU186
A	LYS187
A	GLY221
A	ASP222
A	PHE223
A	PHE239
A	ASN241
A	PHE245
A	HOH441
A	VAL135
A	HOH464
A	HOH524
A	GLY137
A	GLU138
A	THR139
A	ASP161
A	GLY163
A	SER164
A	GLN168

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 418

Chain	Residue
A	ARG203
A	HIS213
A	HOH448
A	HOH553

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 419

Chain	Residue
A	ARG229
A	GLN252
A	GLU255
A	ARG256

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING:

Chain	Residue	Details
A	TYR136
A	PHE159
A	GLU186
A	ASP222

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER297

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER374

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