Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0050661 | molecular_function | NADP binding |
B | 0004146 | molecular_function | dihydrofolate reductase activity |
B | 0006730 | biological_process | one-carbon metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 29 |
Details | BINDING SITE FOR RESIDUE NDP A 193 |
Chain | Residue |
A | VAL10 |
A | ARG56 |
A | LYS57 |
A | THR58 |
A | LEU77 |
A | SER78 |
A | ARG79 |
A | SER94 |
A | ILE112 |
A | GLY114 |
A | ALA115 |
A | ALA11 |
A | GLU116 |
A | ILE117 |
A | TYR118 |
A | GLU120 |
A | GLU174 |
A | QLR194 |
A | HOH205 |
A | HOH239 |
A | HOH243 |
A | HOH272 |
A | ILE19 |
A | GLY20 |
A | GLY23 |
A | LYS24 |
A | MET25 |
A | LYS31 |
A | GLY55 |
site_id | AC2 |
Number of Residues | 30 |
Details | BINDING SITE FOR RESIDUE NDP B 193 |
Chain | Residue |
B | VAL10 |
B | ALA11 |
B | ILE19 |
B | GLY20 |
B | GLY23 |
B | LYS24 |
B | MET25 |
B | GLY55 |
B | ARG56 |
B | LYS57 |
B | THR58 |
B | LEU77 |
B | SER78 |
B | ARG79 |
B | SER94 |
B | SER95 |
B | ILE96 |
B | ILE112 |
B | GLY114 |
B | ALA115 |
B | GLU116 |
B | ILE117 |
B | TYR118 |
B | GLU120 |
B | QLR194 |
B | HOH227 |
B | HOH230 |
B | HOH246 |
B | HOH265 |
B | HOH283 |
site_id | AC3 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE QLR A 194 |
Chain | Residue |
A | ILE9 |
A | VAL10 |
A | ALA11 |
A | GLU32 |
A | PHE36 |
A | THR58 |
A | SER61 |
A | ILE62 |
A | PRO63 |
A | ILE112 |
A | TYR118 |
A | NDP193 |
A | HOH206 |
site_id | AC4 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE QLR B 194 |
Chain | Residue |
B | ILE9 |
B | VAL10 |
B | MET25 |
B | GLU32 |
B | PHE36 |
B | THR58 |
B | SER61 |
B | ILE62 |
B | ILE112 |
B | TYR118 |
B | THR133 |
B | NDP193 |
site_id | AC5 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE GOL A 803 |
Chain | Residue |
A | SER94 |
A | SER95 |
A | SER98 |
A | THR171 |
A | VAL172 |
A | HOH221 |
A | HOH222 |
A | HOH271 |
site_id | AC6 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GLY A 804 |
Chain | Residue |
A | ASN5 |
A | ARG108 |
A | VAL109 |
A | SER128 |
A | HIS129 |
A | PHE167 |
site_id | AC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE GLY A 805 |
Chain | Residue |
A | GLU97 |
A | ASN124 |
A | SER125 |
B | ASN101 |
B | SER104 |
B | HOH218 |
A | LYS3 |
site_id | AC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE GOL B 806 |
Chain | Residue |
A | LYS3 |
B | ILE85 |
B | ASP105 |
B | HOH208 |
B | HOH228 |
B | HOH237 |
Functional Information from PROSITE/UniProt
site_id | PS00075 |
Number of Residues | 23 |
Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. GIGykgkMPWrlrk.EiryFkdvT |
Chain | Residue | Details |
A | GLY18-THR40 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | ALA11 | |
B | GLY113 | |
A | GLY18 | |
A | ARG56 | |
A | SER78 | |
A | GLY113 | |
B | ALA11 | |
B | GLY18 | |
B | ARG56 | |
B | SER78 | |
Chain | Residue | Details |
A | GLU32 | |
A | ILE112 | |
A | TYR118 | |
B | GLU32 | |
B | ILE112 | |
B | TYR118 | |
Chain | Residue | Details |
A | ARG72 | |
B | ARG72 | |