3QID
Crystal structures and functional analysis of murine norovirus RNA-dependent RNA polymerase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| A | 0004386 | molecular_function | helicase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0039694 | biological_process | viral RNA genome replication |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| B | 0004386 | molecular_function | helicase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0039694 | biological_process | viral RNA genome replication |
| C | 0003723 | molecular_function | RNA binding |
| C | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
| C | 0004386 | molecular_function | helicase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006351 | biological_process | DNA-templated transcription |
| C | 0039694 | biological_process | viral RNA genome replication |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1 |
| Chain | Residue |
| A | ASP410 |
| A | ARG411 |
| A | HIS453 |
| A | HOH691 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 521 |
| Chain | Residue |
| A | THR120 |
| A | SER121 |
| A | HOH656 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 A 522 |
| Chain | Residue |
| A | ARG408 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 523 |
| Chain | Residue |
| A | GLY51 |
| A | SER52 |
| A | SER61 |
| A | LEU62 |
| A | THR28 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 524 |
| Chain | Residue |
| A | TYR246 |
| A | THR247 |
| A | ARG248 |
| A | HOH560 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 525 |
| Chain | Residue |
| A | HIS149 |
| A | ASN152 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 526 |
| Chain | Residue |
| A | TRP134 |
| A | GLY136 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 527 |
| Chain | Residue |
| A | PHE238 |
| A | ASP401 |
| A | TRP405 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 528 |
| Chain | Residue |
| A | GLU338 |
| A | ASN353 |
| A | SO4530 |
| B | VAL327 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 529 |
| Chain | Residue |
| A | SER9 |
| A | SER61 |
| A | GLN64 |
| A | ARG67 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 530 |
| Chain | Residue |
| A | ARG239 |
| A | SO4528 |
| B | LYS360 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 531 |
| Chain | Residue |
| A | LYS29 |
| A | HIS426 |
| A | GLN427 |
| A | GLU431 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN3 A 532 |
| Chain | Residue |
| A | ASP243 |
| A | ASP347 |
| A | HOH620 |
| A | HOH648 |
| A | HOH655 |
| A | HOH664 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 533 |
| Chain | Residue |
| A | PRO82 |
| A | GLN83 |
| A | GLU84 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 534 |
| Chain | Residue |
| A | SER223 |
| A | MET224 |
| A | ASN225 |
| A | ASP494 |
| site_id | BC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A 535 |
| Chain | Residue |
| A | GLY157 |
| A | SER159 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 3 |
| Chain | Residue |
| B | ASP410 |
| B | ARG411 |
| B | HIS453 |
| B | HOH597 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 521 |
| Chain | Residue |
| B | LYS158 |
| B | SER159 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 522 |
| Chain | Residue |
| B | ASP117 |
| B | THR120 |
| B | LYS130 |
| B | MET195 |
| B | HOH542 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 523 |
| Chain | Residue |
| A | LYS158 |
| B | LYS29 |
| B | HIS426 |
| B | GLN427 |
| B | GLU431 |
| site_id | CC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 524 |
| Chain | Residue |
| B | HIS149 |
| B | ASN152 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 B 525 |
| Chain | Residue |
| B | ILE85 |
| B | ARG329 |
| B | ASP331 |
| B | HOH647 |
| site_id | CC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 B 526 |
| Chain | Residue |
| B | ARG248 |
| site_id | CC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 527 |
| Chain | Residue |
| B | GLY51 |
| B | SER52 |
| B | SER61 |
| B | LEU62 |
| B | HOH571 |
| site_id | CC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 528 |
| Chain | Residue |
| B | PRO82 |
| B | GLN83 |
| site_id | CC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN3 B 529 |
| Chain | Residue |
| B | ASP243 |
| B | ASP347 |
| B | HOH621 |
| B | HOH642 |
| site_id | CC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 2 |
| Chain | Residue |
| B | SER27 |
| B | THR28 |
| B | ASN425 |
| site_id | DC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 530 |
| Chain | Residue |
| A | THR328 |
| A | GLU355 |
| B | THR328 |
| B | GLU355 |
| B | GOL531 |
| site_id | DC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 531 |
| Chain | Residue |
| B | ASN353 |
| B | GOL530 |
| A | VAL327 |
| A | LYS360 |
| B | GLU338 |
| site_id | DC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 532 |
| Chain | Residue |
| B | THR247 |
| B | ARG248 |
| B | HOH645 |
| site_id | DC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 C 2 |
| Chain | Residue |
| C | HIS149 |
| C | ASN152 |
| site_id | DC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 C 521 |
| Chain | Residue |
| C | ARG408 |
| site_id | DC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 C 522 |
| Chain | Residue |
| C | THR247 |
| C | ARG248 |
| C | HOH615 |
| site_id | DC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 C 523 |
| Chain | Residue |
| C | LYS158 |
| C | SER159 |
| site_id | DC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 524 |
| Chain | Residue |
| C | GLY51 |
| C | SER52 |
| C | SER61 |
| C | LEU62 |
| site_id | DC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE SO4 C 525 |
| Chain | Residue |
| C | ARG248 |
| site_id | EC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 C 526 |
| Chain | Residue |
| C | ASP410 |
| C | ARG411 |
| C | HIS453 |
| C | HOH608 |
| site_id | EC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MN3 C 527 |
| Chain | Residue |
| C | ASP243 |
| C | ASP347 |
| C | HOH633 |
| site_id | EC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL C 1 |
| Chain | Residue |
| C | SER27 |
| C | THR28 |
| C | LYS29 |
| C | ASN425 |
| site_id | EC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL C 528 |
| Chain | Residue |
| C | THR11 |
| C | ALA13 |
| C | GLY14 |
| site_id | EC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL C 529 |
| Chain | Residue |
| B | LYS158 |
| C | ASN425 |
| C | HIS426 |
| C | GLN427 |
| C | ASN428 |
| C | GLU431 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21471315, ECO:0000269|PubMed:22341781, ECO:0000269|PubMed:24622391 |
| Chain | Residue | Details |
| A | ASP243 | |
| A | GLU348 | |
| B | ASP243 | |
| B | GLU348 | |
| C | ASP243 | |
| C | GLU348 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21471315 |
| Chain | Residue | Details |
| A | ASP245 | |
| B | ASP245 | |
| C | ASP245 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21471315, ECO:0000269|PubMed:24622391 |
| Chain | Residue | Details |
| A | ASP347 | |
| B | ASP347 | |
| C | ASP347 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:22341781, ECO:0000269|PubMed:24622391 |
| Chain | Residue | Details |
| A | SER392 | |
| B | SER392 | |
| C | SER392 |
