3QID

Crystal structures and functional analysis of murine norovirus RNA-dependent RNA polymerase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003968	molecular_function	RNA-directed RNA polymerase activity
A	0004386	molecular_function	helicase activity
A	0005524	molecular_function	ATP binding
A	0006351	biological_process	DNA-templated transcription
A	0039694	biological_process	viral RNA genome replication
B	0003723	molecular_function	RNA binding
B	0003968	molecular_function	RNA-directed RNA polymerase activity
B	0004386	molecular_function	helicase activity
B	0005524	molecular_function	ATP binding
B	0006351	biological_process	DNA-templated transcription
B	0039694	biological_process	viral RNA genome replication
C	0003723	molecular_function	RNA binding
C	0003968	molecular_function	RNA-directed RNA polymerase activity
C	0004386	molecular_function	helicase activity
C	0005524	molecular_function	ATP binding
C	0006351	biological_process	DNA-templated transcription
C	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 1

Chain	Residue
A	ASP410
A	ARG411
A	HIS453
A	HOH691

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 521

Chain	Residue
A	THR120
A	SER121
A	HOH656

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 A 522

Chain	Residue
A	ARG408

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 523

Chain	Residue
A	GLY51
A	SER52
A	SER61
A	LEU62
A	THR28

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 524

Chain	Residue
A	TYR246
A	THR247
A	ARG248
A	HOH560

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 525

Chain	Residue
A	HIS149
A	ASN152

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 526

Chain	Residue
A	TRP134
A	GLY136

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 527

Chain	Residue
A	PHE238
A	ASP401
A	TRP405

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 528

Chain	Residue
A	GLU338
A	ASN353
A	SO4530
B	VAL327

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 529

Chain	Residue
A	SER9
A	SER61
A	GLN64
A	ARG67

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 530

Chain	Residue
A	ARG239
A	SO4528
B	LYS360

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 531

Chain	Residue
A	LYS29
A	HIS426
A	GLN427
A	GLU431

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN3 A 532

Chain	Residue
A	ASP243
A	ASP347
A	HOH620
A	HOH648
A	HOH655
A	HOH664

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 533

Chain	Residue
A	PRO82
A	GLN83
A	GLU84

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 534

Chain	Residue
A	SER223
A	MET224
A	ASN225
A	ASP494

---

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 535

Chain	Residue
A	GLY157
A	SER159

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 3

Chain	Residue
B	ASP410
B	ARG411
B	HIS453
B	HOH597

---

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 521

Chain	Residue
B	LYS158
B	SER159

---

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 522

Chain	Residue
B	ASP117
B	THR120
B	LYS130
B	MET195
B	HOH542

---

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 523

Chain	Residue
A	LYS158
B	LYS29
B	HIS426
B	GLN427
B	GLU431

---

site_id	CC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 524

Chain	Residue
B	HIS149
B	ASN152

---

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 525

Chain	Residue
B	ILE85
B	ARG329
B	ASP331
B	HOH647

---

site_id	CC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 B 526

Chain	Residue
B	ARG248

---

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 527

Chain	Residue
B	GLY51
B	SER52
B	SER61
B	LEU62
B	HOH571

---

site_id	CC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 528

Chain	Residue
B	PRO82
B	GLN83

---

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN3 B 529

Chain	Residue
B	ASP243
B	ASP347
B	HOH621
B	HOH642

---

site_id	CC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL B 2

Chain	Residue
B	SER27
B	THR28
B	ASN425

---

site_id	DC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 530

Chain	Residue
A	THR328
A	GLU355
B	THR328
B	GLU355
B	GOL531

---

site_id	DC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 531

Chain	Residue
B	ASN353
B	GOL530
A	VAL327
A	LYS360
B	GLU338

---

site_id	DC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL B 532

Chain	Residue
B	THR247
B	ARG248
B	HOH645

---

site_id	DC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 2

Chain	Residue
C	HIS149
C	ASN152

---

site_id	DC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 C 521

Chain	Residue
C	ARG408

---

site_id	DC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 522

Chain	Residue
C	THR247
C	ARG248
C	HOH615

---

site_id	DC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 523

Chain	Residue
C	LYS158
C	SER159

---

site_id	DC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 524

Chain	Residue
C	GLY51
C	SER52
C	SER61
C	LEU62

---

site_id	DC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE SO4 C 525

Chain	Residue
C	ARG248

---

site_id	EC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 526

Chain	Residue
C	ASP410
C	ARG411
C	HIS453
C	HOH608

---

site_id	EC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MN3 C 527

Chain	Residue
C	ASP243
C	ASP347
C	HOH633

---

site_id	EC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL C 1

Chain	Residue
C	SER27
C	THR28
C	LYS29
C	ASN425

---

site_id	EC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL C 528

Chain	Residue
C	THR11
C	ALA13
C	GLY14

---

site_id	EC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C 529

Chain	Residue
B	LYS158
C	ASN425
C	HIS426
C	GLN427
C	ASN428
C	GLU431

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	363
Details	Domain: {"description":"RdRp catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00539","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21471315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22341781","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24622391","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21471315","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21471315","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24622391","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22341781","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24622391","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---