Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0050661 | molecular_function | NADP binding |
| B | 0004146 | molecular_function | dihydrofolate reductase activity |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 36 |
| Details | BINDING SITE FOR RESIDUE NDP A 601 |
| Chain | Residue |
| A | VAL33 |
| A | GLY83 |
| A | ARG84 |
| A | LYS85 |
| A | THR86 |
| A | LEU105 |
| A | SER106 |
| A | ARG107 |
| A | GLY136 |
| A | GLY137 |
| A | ILE160 |
| A | ALA34 |
| A | GLY161 |
| A | GLY162 |
| A | GLY163 |
| A | THR164 |
| A | ILE165 |
| A | TYR166 |
| A | GLN168 |
| A | CP6602 |
| A | HOH1021 |
| A | HOH1053 |
| A | ILE41 |
| A | HOH1131 |
| A | HOH1132 |
| A | HOH1180 |
| A | HOH1215 |
| A | HOH1291 |
| A | HOH1327 |
| B | SER241 |
| A | GLY42 |
| A | ASP43 |
| A | GLY44 |
| A | GLY45 |
| A | THR46 |
| A | ILE47 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE CP6 A 602 |
| Chain | Residue |
| A | VAL32 |
| A | VAL33 |
| A | ALA34 |
| A | ILE47 |
| A | ASP54 |
| A | MET55 |
| A | PHE58 |
| A | THR86 |
| A | SER89 |
| A | LEU90 |
| A | ILE160 |
| A | TYR166 |
| A | THR184 |
| A | NDP601 |
| site_id | AC3 |
| Number of Residues | 33 |
| Details | BINDING SITE FOR RESIDUE NDP B 701 |
| Chain | Residue |
| A | SER241 |
| B | VAL33 |
| B | ALA34 |
| B | ILE41 |
| B | ASP43 |
| B | GLY44 |
| B | GLY45 |
| B | THR46 |
| B | ILE47 |
| B | GLY83 |
| B | ARG84 |
| B | LYS85 |
| B | THR86 |
| B | LEU105 |
| B | SER106 |
| B | ARG107 |
| B | GLY136 |
| B | GLY137 |
| B | ILE160 |
| B | GLY161 |
| B | GLY162 |
| B | GLY163 |
| B | THR164 |
| B | ILE165 |
| B | TYR166 |
| B | GLN168 |
| B | CP6702 |
| B | HOH1012 |
| B | HOH1081 |
| B | HOH1151 |
| B | HOH1160 |
| B | HOH1315 |
| B | HOH1317 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE CP6 B 702 |
| Chain | Residue |
| B | VAL32 |
| B | VAL33 |
| B | ALA34 |
| B | ILE47 |
| B | ASP54 |
| B | MET55 |
| B | PHE58 |
| B | THR86 |
| B | SER89 |
| B | LEU90 |
| B | ILE160 |
| B | TYR166 |
| B | THR184 |
| B | NDP701 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 23 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. GIGdggtIPWeipe.DmqyFrrvT |
| Chain | Residue | Details |
| A | GLY40-THR62 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | VAL32 | |
| A | THR184 | |
| B | VAL32 | |
| B | ALA34 | |
| B | GLY40 | |
| B | ASP54 | |
| B | ARG84 | |
| B | LEU105 | |
| B | ILE160 | |
| B | GLY161 | |
| B | TYR166 | |
| A | ALA34 | |
| B | THR184 | |
| A | GLY40 | |
| A | ASP54 | |
| A | ARG84 | |
| A | LEU105 | |
| A | ILE160 | |
| A | GLY161 | |
| A | TYR166 | |
