3QCZ
Crystal structure of bifunctional folylpolyglutamate synthase/dihydrofolate synthase with Mn, AMPPNP and L-Glutamate bound
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004326 | molecular_function | tetrahydrofolylpolyglutamate synthase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006761 | biological_process | dihydrofolate biosynthetic process |
| A | 0008841 | molecular_function | dihydrofolate synthase activity |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0016881 | molecular_function | acid-amino acid ligase activity |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046656 | biological_process | folic acid biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0046901 | biological_process | tetrahydrofolylpolyglutamate biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE ANP A 501 |
| Chain | Residue |
| A | THR57 |
| A | ASN269 |
| A | ARG301 |
| A | ASP314 |
| A | VAL315 |
| A | ALA316 |
| A | HIS317 |
| A | HIS320 |
| A | ALA321 |
| A | TYR324 |
| A | PHE422 |
| A | ASN58 |
| A | HOH436 |
| A | HOH437 |
| A | HOH458 |
| A | HOH531 |
| A | HOH596 |
| A | MN601 |
| A | GLY59 |
| A | LYS60 |
| A | GLY61 |
| A | THR62 |
| A | SER83 |
| A | PRO84 |
| A | GLU146 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 601 |
| Chain | Residue |
| A | SER83 |
| A | GLU146 |
| A | HOH436 |
| A | HOH437 |
| A | ANP501 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 435 |
| Chain | Residue |
| A | TYR179 |
| A | ARG255 |
| A | GLN256 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE GOL A 602 |
| Chain | Residue |
| A | ARG323 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GLU A 701 |
| Chain | Residue |
| A | THR57 |
| A | LEU149 |
| A | GLY150 |
| A | ALA170 |
| A | LEU171 |
| A | ASP172 |
| A | HIS173 |
| A | TYR179 |
| A | LYS188 |
| A | HOH465 |
Functional Information from PROSITE/UniProt
| site_id | PS01012 |
| Number of Residues | 16 |
| Details | FOLYLPOLYGLU_SYNT_2 Folylpolyglutamate synthase signature 2. ILEvGLGGrlDaTnIV |
| Chain | Residue | Details |
| A | ILE144-VAL159 |
