3QCZ
Crystal structure of bifunctional folylpolyglutamate synthase/dihydrofolate synthase with Mn, AMPPNP and L-Glutamate bound
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004326 | molecular_function | tetrahydrofolylpolyglutamate synthase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0006761 | biological_process | dihydrofolate biosynthetic process |
A | 0008841 | molecular_function | dihydrofolate synthase activity |
A | 0009058 | biological_process | biosynthetic process |
A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
A | 0016874 | molecular_function | ligase activity |
A | 0016881 | molecular_function | acid-amino acid ligase activity |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0046656 | biological_process | folic acid biosynthetic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0046901 | biological_process | tetrahydrofolylpolyglutamate biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 25 |
Details | BINDING SITE FOR RESIDUE ANP A 501 |
Chain | Residue |
A | THR57 |
A | ASN269 |
A | ARG301 |
A | ASP314 |
A | VAL315 |
A | ALA316 |
A | HIS317 |
A | HIS320 |
A | ALA321 |
A | TYR324 |
A | PHE422 |
A | ASN58 |
A | HOH436 |
A | HOH437 |
A | HOH458 |
A | HOH531 |
A | HOH596 |
A | MN601 |
A | GLY59 |
A | LYS60 |
A | GLY61 |
A | THR62 |
A | SER83 |
A | PRO84 |
A | GLU146 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN A 601 |
Chain | Residue |
A | SER83 |
A | GLU146 |
A | HOH436 |
A | HOH437 |
A | ANP501 |
site_id | AC3 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE GOL A 435 |
Chain | Residue |
A | TYR179 |
A | ARG255 |
A | GLN256 |
site_id | AC4 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE GOL A 602 |
Chain | Residue |
A | ARG323 |
site_id | AC5 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE GLU A 701 |
Chain | Residue |
A | THR57 |
A | LEU149 |
A | GLY150 |
A | ALA170 |
A | LEU171 |
A | ASP172 |
A | HIS173 |
A | TYR179 |
A | LYS188 |
A | HOH465 |
Functional Information from PROSITE/UniProt
site_id | PS01012 |
Number of Residues | 16 |
Details | FOLYLPOLYGLU_SYNT_2 Folylpolyglutamate synthase signature 2. ILEvGLGGrlDaTnIV |
Chain | Residue | Details |
A | ILE144-VAL159 |