3QCT

Crystal structure of the humanized apo LT3015 anti-lysophosphatidic acid antibody Fab fragment

Functional Information from GO Data

Chain	GOid	namespace	contents
L	0002250	biological_process	adaptive immune response
L	0002376	biological_process	immune system process
L	0003823	molecular_function	antigen binding
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005615	cellular_component	extracellular space
L	0005886	cellular_component	plasma membrane
L	0006955	biological_process	immune response
L	0016064	biological_process	immunoglobulin mediated immune response
L	0019814	cellular_component	immunoglobulin complex
L	0050853	biological_process	B cell receptor signaling pathway
L	0070062	cellular_component	extracellular exosome
L	0071735	cellular_component	IgG immunoglobulin complex
L	0072562	cellular_component	blood microparticle

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 H 215

Chain	Residue
H	TYR99
L	LYS50
H	GLY100
H	SER100
H	GLY100
H	TYR100
H	SER113
H	HOH222
L	ASN30
L	TYR32

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 H 216

Chain	Residue
H	ARG94
H	GLY97
H	TYR98
H	ASN100
H	HOH247

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PGE L 214

Chain	Residue
H	TYR99
H	SER172
L	THR92
L	PHE94

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
H	TYR194-HIS200
L	TYR192-HIS198

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	97
Details	Domain: {"description":"Ig-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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