3Q1L

Crystals Structure of Aspartate beta-Semialdehyde Dehydrogenase from Streptococcus pneumoniae with cysteamine bound covalently to Cys 128

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004073	molecular_function	aspartate-semialdehyde dehydrogenase activity
A	0008652	biological_process	amino acid biosynthetic process
A	0009085	biological_process	lysine biosynthetic process
A	0009086	biological_process	methionine biosynthetic process
A	0009088	biological_process	threonine biosynthetic process
A	0009089	biological_process	lysine biosynthetic process via diaminopimelate
A	0009097	biological_process	isoleucine biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0019877	biological_process	diaminopimelate biosynthetic process
A	0046983	molecular_function	protein dimerization activity
A	0050661	molecular_function	NADP binding
A	0051287	molecular_function	NAD binding
A	0071266	biological_process	'de novo' L-methionine biosynthetic process
B	0000166	molecular_function	nucleotide binding
B	0004073	molecular_function	aspartate-semialdehyde dehydrogenase activity
B	0008652	biological_process	amino acid biosynthetic process
B	0009085	biological_process	lysine biosynthetic process
B	0009086	biological_process	methionine biosynthetic process
B	0009088	biological_process	threonine biosynthetic process
B	0009089	biological_process	lysine biosynthetic process via diaminopimelate
B	0009097	biological_process	isoleucine biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0019877	biological_process	diaminopimelate biosynthetic process
B	0046983	molecular_function	protein dimerization activity
B	0050661	molecular_function	NADP binding
B	0051287	molecular_function	NAD binding
B	0071266	biological_process	'de novo' L-methionine biosynthetic process
C	0000166	molecular_function	nucleotide binding
C	0004073	molecular_function	aspartate-semialdehyde dehydrogenase activity
C	0008652	biological_process	amino acid biosynthetic process
C	0009085	biological_process	lysine biosynthetic process
C	0009086	biological_process	methionine biosynthetic process
C	0009088	biological_process	threonine biosynthetic process
C	0009089	biological_process	lysine biosynthetic process via diaminopimelate
C	0009097	biological_process	isoleucine biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0019877	biological_process	diaminopimelate biosynthetic process
C	0046983	molecular_function	protein dimerization activity
C	0050661	molecular_function	NADP binding
C	0051287	molecular_function	NAD binding
C	0071266	biological_process	'de novo' L-methionine biosynthetic process
D	0000166	molecular_function	nucleotide binding
D	0004073	molecular_function	aspartate-semialdehyde dehydrogenase activity
D	0008652	biological_process	amino acid biosynthetic process
D	0009085	biological_process	lysine biosynthetic process
D	0009086	biological_process	methionine biosynthetic process
D	0009088	biological_process	threonine biosynthetic process
D	0009089	biological_process	lysine biosynthetic process via diaminopimelate
D	0009097	biological_process	isoleucine biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0019877	biological_process	diaminopimelate biosynthetic process
D	0046983	molecular_function	protein dimerization activity
D	0050661	molecular_function	NADP binding
D	0051287	molecular_function	NAD binding
D	0071266	biological_process	'de novo' L-methionine biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE DHL A 367

Chain	Residue
A	ASN127
A	CYS128
A	GLN155
A	GLY159
A	ILE209
A	GLU220
A	ARG245
A	HIS252

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE DHL B 367

Chain	Residue
B	CYS128
B	GLN155
B	GLY159
B	GLU220
B	ARG245
B	HIS252
B	ASN127

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE DHL C 367

Chain	Residue
C	CYS128
C	GLY159
C	HIS252
C	ASN325

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site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE DHL D 367

Chain	Residue
D	CYS128
D	GLN155
D	GLY159
D	ILE209
D	GLU220
D	ARG245

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