3PWK
Crystal Structure of Aspartate beta-Semialdehide Dehydrogenase from Streptococcus pneumoniae with 2',5'-Adenosine diphosphate and D-2-aminoadipate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009086 | biological_process | methionine biosynthetic process |
| A | 0009088 | biological_process | threonine biosynthetic process |
| A | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| A | 0009097 | biological_process | isoleucine biosynthetic process |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| A | 0046983 | molecular_function | protein dimerization activity |
| A | 0050661 | molecular_function | NADP binding |
| A | 0051287 | molecular_function | NAD binding |
| B | 0004073 | molecular_function | aspartate-semialdehyde dehydrogenase activity |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0009086 | biological_process | methionine biosynthetic process |
| B | 0009088 | biological_process | threonine biosynthetic process |
| B | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| B | 0009097 | biological_process | isoleucine biosynthetic process |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0046983 | molecular_function | protein dimerization activity |
| B | 0050661 | molecular_function | NADP binding |
| B | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE 25A A 367 |
| Chain | Residue |
| A | GLY9 |
| A | ALA72 |
| A | THR76 |
| A | GLY161 |
| A | MET162 |
| A | HOH451 |
| A | HOH544 |
| A | HOH548 |
| A | HOH639 |
| A | HOH711 |
| A | HOH1212 |
| A | THR11 |
| A | GLY12 |
| A | ALA13 |
| A | ALA36 |
| A | SER37 |
| A | ARG39 |
| A | SER40 |
| A | THR57 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE 25A B 367 |
| Chain | Residue |
| B | GLY9 |
| B | THR11 |
| B | GLY12 |
| B | ALA13 |
| B | ALA36 |
| B | SER37 |
| B | ARG39 |
| B | SER40 |
| B | THR57 |
| B | ALA72 |
| B | THR76 |
| B | GLY161 |
| B | MET162 |
| B | HOH447 |
| B | HOH536 |
| B | HOH600 |
| B | HOH603 |
| B | HOH604 |
| B | HOH625 |
| B | HOH628 |
| B | HOH718 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE L14 A 368 |
| Chain | Residue |
| A | SER96 |
| A | ARG99 |
| A | GLY159 |
| A | ALA160 |
| A | GLU220 |
| A | LYS223 |
| A | ARG245 |
| A | HOH589 |
| A | HOH1220 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE L14 B 368 |
| Chain | Residue |
| B | SER96 |
| B | ARG99 |
| B | ASN127 |
| B | GLY159 |
| B | ALA160 |
| B | GLU220 |
| B | LYS223 |
| B | ARG245 |
| B | HOH653 |
| B | HOH888 |
| B | HOH1237 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO B 369 |
| Chain | Residue |
| A | THR26 |
| A | EDO369 |
| A | HOH592 |
| B | GLU24 |
| B | SER25 |
| B | TRP332 |
| B | GLU339 |
| B | HOH446 |
| B | HOH587 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO A 369 |
| Chain | Residue |
| A | GLU24 |
| A | SER25 |
| A | TRP332 |
| A | GLU339 |
| A | HOH376 |
| A | HOH498 |
| A | HOH592 |
| B | THR26 |
| B | EDO369 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 370 |
| Chain | Residue |
| A | SER250 |
| A | GLY298 |
| A | ASP324 |
| A | LEU326 |
| A | HOH555 |
| A | HOH950 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 370 |
| Chain | Residue |
| B | SER250 |
| B | GLY298 |
| B | ASP324 |
| B | LEU326 |
| B | HOH466 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 371 |
| Chain | Residue |
| A | ASP312 |
| A | HOH497 |
| A | HOH1319 |
| B | LYS229 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 371 |
| Chain | Residue |
| A | GLY2 |
| A | PRO28 |
| B | HOH436 |
| B | HOH1204 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO B 372 |
| Chain | Residue |
| B | HOH416 |
| A | LYS229 |
| B | ASP312 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO A 372 |
| Chain | Residue |
| A | HOH402 |
| B | GLY2 |
| B | HOH1121 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 373 |
| Chain | Residue |
| A | ILE273 |
| A | ALA274 |
| A | PHE276 |
| A | ALA279 |
| B | GLU343 |
| B | HOH613 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 373 |
| Chain | Residue |
| B | ASP147 |
| B | SER236 |
| B | HOH474 |
| B | HOH914 |
| B | HOH939 |
