Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005737 | cellular_component | cytoplasm |
A | 0008239 | molecular_function | dipeptidyl-peptidase activity |
A | 0016787 | molecular_function | hydrolase activity |
A | 0050784 | biological_process | cocaine catabolic process |
A | 0052689 | molecular_function | carboxylic ester hydrolase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL A 588 |
Chain | Residue |
A | LYS298 |
A | ARG472 |
site_id | AC2 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL A 589 |
Chain | Residue |
A | GLY365 |
A | HOH1268 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CL A 590 |
Chain | Residue |
A | HOH909 |
A | ASN197 |
A | GLY300 |
A | ILE301 |
A | ALA302 |
A | HOH829 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CL A 591 |
Chain | Residue |
A | TRP345 |
A | HOH904 |
A | HOH1013 |
A | HOH1060 |
site_id | AC5 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE NA A 592 |
Chain | Residue |
A | MET141 |
A | ALA255 |
A | GLY256 |
A | ASP259 |
A | PHE261 |
A | VAL262 |
A | SER265 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL A 593 |
Chain | Residue |
A | ASP470 |
A | ARG472 |
A | HOH697 |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | SER117 | |
Chain | Residue | Details |
A | ASP259 | |
A | HIS287 | |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | BINDING: |
Chain | Residue | Details |
A | TYR44 | |
A | TYR118 | |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | SITE: Probably involved in activating the substrate carbonyl and the acyl enzyme for hydrolysis |
Chain | Residue | Details |
A | TYR44 | |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 6 |
Details | M-CSA 465 |
Chain | Residue | Details |
A | TYR44 | transition state stabiliser |
A | SER117 | covalent catalysis, proton shuttle (general acid/base) |
A | TYR118 | electrostatic stabiliser |
A | TRP166 | activator |
A | ASP259 | activator, electrostatic stabiliser |
A | HIS287 | proton shuttle (general acid/base) |