Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008239 | molecular_function | dipeptidyl-peptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0050784 | biological_process | cocaine catabolic process |
| A | 0052689 | molecular_function | carboxylic ester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 588 |
| Chain | Residue |
| A | LYS298 |
| A | ARG472 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL A 589 |
| Chain | Residue |
| A | GLY365 |
| A | HOH1268 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL A 590 |
| Chain | Residue |
| A | HOH909 |
| A | ASN197 |
| A | GLY300 |
| A | ILE301 |
| A | ALA302 |
| A | HOH829 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL A 591 |
| Chain | Residue |
| A | TRP345 |
| A | HOH904 |
| A | HOH1013 |
| A | HOH1060 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA A 592 |
| Chain | Residue |
| A | MET141 |
| A | ALA255 |
| A | GLY256 |
| A | ASP259 |
| A | PHE261 |
| A | VAL262 |
| A | SER265 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 593 |
| Chain | Residue |
| A | ASP470 |
| A | ARG472 |
| A | HOH697 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 95 |
| Details | Region: {"description":"2"} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 113 |
| Details | Region: {"description":"1B"} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 219 |
| Details | Region: {"description":"3"} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Acyl-ester intermediate","evidences":[{"source":"PubMed","id":"11742345","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"11742345","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Site: {"description":"Probably involved in activating the substrate carbonyl and the acyl enzyme for hydrolysis"} |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 465 |
| Chain | Residue | Details |
| A | TYR44 | transition state stabiliser |
| A | SER117 | covalent catalysis, proton shuttle (general acid/base) |
| A | TYR118 | electrostatic stabiliser |
| A | TRP166 | activator |
| A | ASP259 | activator, electrostatic stabiliser |
| A | HIS287 | proton shuttle (general acid/base) |
