3PS5
Crystal structure of the full-length Human Protein Tyrosine Phosphatase SHP-1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000278 | biological_process | mitotic cell cycle |
| A | 0001784 | molecular_function | phosphotyrosine residue binding |
| A | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| A | 0004725 | molecular_function | protein tyrosine phosphatase activity |
| A | 0004726 | molecular_function | non-membrane spanning protein tyrosine phosphatase activity |
| A | 0005001 | molecular_function | transmembrane receptor protein tyrosine phosphatase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005730 | cellular_component | nucleolus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005911 | cellular_component | cell-cell junction |
| A | 0006470 | biological_process | protein dephosphorylation |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0008285 | biological_process | negative regulation of cell population proliferation |
| A | 0016020 | cellular_component | membrane |
| A | 0016311 | biological_process | dephosphorylation |
| A | 0016525 | biological_process | negative regulation of angiogenesis |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0017124 | molecular_function | SH3 domain binding |
| A | 0018108 | biological_process | peptidyl-tyrosine phosphorylation |
| A | 0019221 | biological_process | cytokine-mediated signaling pathway |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0030154 | biological_process | cell differentiation |
| A | 0031295 | biological_process | T cell costimulation |
| A | 0031665 | biological_process | negative regulation of lipopolysaccharide-mediated signaling pathway |
| A | 0032715 | biological_process | negative regulation of interleukin-6 production |
| A | 0032720 | biological_process | negative regulation of tumor necrosis factor production |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0033007 | biological_process | negative regulation of mast cell activation involved in immune response |
| A | 0035335 | biological_process | peptidyl-tyrosine dephosphorylation |
| A | 0035580 | cellular_component | specific granule lumen |
| A | 0042105 | cellular_component | alpha-beta T cell receptor complex |
| A | 0042110 | biological_process | T cell activation |
| A | 0042169 | molecular_function | SH2 domain binding |
| A | 0042981 | biological_process | regulation of apoptotic process |
| A | 0045824 | biological_process | negative regulation of innate immune response |
| A | 0050839 | molecular_function | cell adhesion molecule binding |
| A | 0050859 | biological_process | negative regulation of B cell receptor signaling pathway |
| A | 0051897 | biological_process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| A | 0060338 | biological_process | regulation of type I interferon-mediated signaling pathway |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070372 | biological_process | regulation of ERK1 and ERK2 cascade |
| A | 0106015 | biological_process | negative regulation of inflammatory response to wounding |
| A | 0140031 | molecular_function | phosphorylation-dependent protein binding |
| A | 0160162 | biological_process | CD27 signaling pathway |
| A | 1902564 | biological_process | negative regulation of neutrophil activation |
| A | 1904724 | cellular_component | tertiary granule lumen |
| A | 1905867 | biological_process | epididymis development |
| A | 2000045 | biological_process | regulation of G1/S transition of mitotic cell cycle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 596 |
| Chain | Residue |
| A | ARG136 |
| A | SER138 |
| A | LEU139 |
| A | SER140 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 597 |
| Chain | Residue |
| A | ARG21 |
| A | LYS520 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A 598 |
| Chain | Residue |
| A | THR188 |
| A | THR106 |
| A | SER107 |
| A | GLU108 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 599 |
| Chain | Residue |
| A | SER453 |
| A | SER454 |
| A | ALA455 |
| A | GLY456 |
| A | ILE457 |
| A | GLY458 |
| A | ARG459 |
| A | THR460 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 600 |
| Chain | Residue |
| A | ARG30 |
| A | SER32 |
| A | ARG33 |
| A | LYS34 |
| A | SER40 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 96 |
| Details | Domain: {"description":"SH2 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 103 |
| Details | Domain: {"description":"SH2 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 271 |
| Details | Domain: {"description":"Tyrosine-protein phosphatase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00160","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Phosphocysteine intermediate"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P81718","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P29351","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P29351","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine; by TAOK3","evidences":[{"source":"PubMed","id":"38166031","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"29925997","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
