3PNL

Crystal Structure of E.coli Dha kinase DhaK-DhaL complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004371	molecular_function	glycerone kinase activity
A	0005515	molecular_function	protein binding
A	0005829	cellular_component	cytosol
A	0006071	biological_process	glycerol metabolic process
A	0006974	biological_process	DNA damage response
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0019563	biological_process	glycerol catabolic process
A	0042182	biological_process	ketone catabolic process
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0046365	biological_process	monosaccharide catabolic process
A	0046835	biological_process	carbohydrate phosphorylation
A	0047324	molecular_function	phosphoenolpyruvate-glycerone phosphotransferase activity
A	0061610	biological_process	glycerol catabolic process to glycerone phosphate
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0004371	molecular_function	glycerone kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006071	biological_process	glycerol metabolic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
B	0019563	biological_process	glycerol catabolic process
B	0043531	molecular_function	ADP binding
B	0046835	biological_process	carbohydrate phosphorylation
B	0046872	molecular_function	metal ion binding
B	0047324	molecular_function	phosphoenolpyruvate-glycerone phosphotransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 1228

Chain	Residue
A	GLY52
B	HOH231
A	GLY53
A	HIS56
A	PHE78
A	SER80
A	LYS104
A	ASP109
A	HIS218
B	ARG178

---

site_id	AC2
Number of Residues	25
Details	BINDING SITE FOR RESIDUE ADP B 1211

Chain	Residue
A	THR107
A	HOH359
B	ASP30
B	ASP35
B	ASP37
B	HIS38
B	ASN41
B	GLY78
B	ALA79
B	SER80
B	LEU83
B	GLY121
B	THR129
B	MET130
B	GLY177
B	ASP191
B	PRO192
B	GLY193
B	HOH215
B	HOH216
B	HOH231
B	HOH243
B	HOH254
B	MG1212
B	MG1213

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 1212

Chain	Residue
B	ASP30
B	ASP35
B	ASP37
B	HOH254
B	ADP1211
B	MG1213

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 1213

Chain	Residue
A	PHE78
B	ASP35
B	ASP37
B	HOH231
B	ADP1211
B	MG1212

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	345
Details	Domain: {"description":"DhaK","evidences":[{"source":"PROSITE-ProRule","id":"PRU00814","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"21209328","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Tele-hemiaminal-histidine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00814","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12813127","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15476397","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21209328","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1OI2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UOE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PNL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PNQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12813127","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15476397","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21209328","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1OI2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UOD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1UOE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PNL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PNQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12813127","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21209328","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1OI2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PNK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PNL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PNQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	200
Details	Domain: {"description":"DhaL","evidences":[{"source":"PROSITE-ProRule","id":"PRU00813","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16647083","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24440518","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BTD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LRZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16647083","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21209328","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24440518","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2BTD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3PNL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4LRZ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"16647083","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21209328","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2BTD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---