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3PMN

ternary crystal structure of polymerase lambda variant with a GT mispair at the primer terminus with Mn2+ in the active site

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0003887molecular_functionDNA-directed DNA polymerase activity
A0006281biological_processDNA repair
A0016779molecular_functionnucleotidyltransferase activity
A0034061molecular_functionDNA polymerase activity
Functional Information from PDB Data
site_idAC1
Number of Residues25
DetailsBINDING SITE FOR RESIDUE 1GC A 1
ChainResidue
AMN2
AASP427
AASP429
ATYR505
APHE506
ATHR507
AGLY508
AALA510
AASN513
AARG517
AMG576
AHOH3
AHOH577
AHOH578
AHOH629
BDC5
CDG6
CHOH72
AHOH27
AHOH53
AARG386
AGLY416
ASER417
AARG420
AGLY426

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 576
ChainResidue
A1GC1
AMN2
AASP427
AASP429
AHOH578

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MN A 2
ChainResidue
A1GC1
AASP427
AASP429
AASP490
AMG576
AHOH577
CDG6

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE NA A 5
ChainResidue
ASER339
AILE341
AALA344
AHOH580
CDA5
CHOH10

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN A 6
ChainResidue
ACL8
AASP382
AHIS486
AHOH588
AHOH589
AHOH590

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MN A 7
ChainResidue
AHOH30
AHIS530
AHOH602
BDA8

site_idAC7
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL A 8
ChainResidue
AMN6
AHOH588

site_idAC8
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CL A 9
ChainResidue
AARG514

site_idAC9
Number of Residues5
DetailsBINDING SITE FOR RESIDUE NA A 10
ChainResidue
ACYS300
AILE302
AILE305
AHOH632
DDC3

Functional Information from PROSITE/UniProt
site_idPS00522
Number of Residues20
DetailsDNA_POLYMERASE_X DNA polymerase family X signature. GSYrRGkatCgDVDVLIthP
ChainResidueDetails
AGLY416-PRO435

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Schiff-base intermediate with DNA => ECO:0000269|PubMed:11457865
ChainResidueDetails
ALYS312

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ
ChainResidueDetails
AARG386
ASER417
AGLY426
AALA518

site_idSWS_FT_FI3
Number of Residues3
DetailsBINDING: BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ
ChainResidueDetails
AASP427
AASP429
APRO495

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PDB entries from 2024-10-30

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