3PM8
CAD domain of PFF0520w, Calcium dependent protein kinase
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1 |
| Chain | Residue |
| A | HOH2 |
| A | ASP455 |
| A | ASP457 |
| A | ASN459 |
| A | LYS461 |
| A | GLU466 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 514 |
| Chain | Residue |
| A | ASP497 |
| A | GLU499 |
| A | GLU504 |
| A | HOH3 |
| A | ASP493 |
| A | ASN495 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 515 |
| Chain | Residue |
| A | ASP383 |
| A | ASP385 |
| A | SER387 |
| A | THR389 |
| A | GLU394 |
| A | GLN425 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NA A 516 |
| Chain | Residue |
| A | PHE502 |
| A | HIS503 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 517 |
| Chain | Residue |
| A | GLU354 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 1 |
| Chain | Residue |
| B | ASP383 |
| B | ASP385 |
| B | SER387 |
| B | THR389 |
| B | GLU394 |
| B | HOH519 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 514 |
| Chain | Residue |
| B | ASP455 |
| B | ASP457 |
| B | ASN459 |
| B | LYS461 |
| B | GLU466 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 515 |
| Chain | Residue |
| B | HOH4 |
| B | ASP493 |
| B | ASN495 |
| B | ASP497 |
| B | GLU499 |
| B | GLU504 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 516 |
| Chain | Residue |
| A | LYS483 |
| B | HOH142 |
| B | HOH145 |
| B | ASN353 |
| B | GLU354 |
| site_id | BC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE NA B 517 |
| Chain | Residue |
| B | VAL370 |
| site_id | BC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 518 |
| Chain | Residue |
| A | LYS444 |
| B | ASN386 |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DVDNSGTLSsqEI |
| Chain | Residue | Details |
| A | ASP383-ILE395 | |
| A | ASP455-LEU467 | |
| A | ASP493-PHE505 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 70 |
| Details | Region: {"description":"J domain","evidences":[{"source":"UniProtKB","id":"Q8IBS5","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | Motif: {"description":"J domain autoinhibitory motif","evidences":[{"source":"UniProtKB","id":"Q8IBS5","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 18 |
| Details | Motif: {"description":"J domain EF-hand interaction motif","evidences":[{"source":"UniProtKB","id":"Q8IBS5","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 20 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2010","submissionDatabase":"PDB data bank","title":"CAD domain of PFF0520w, Calcium dependent protein kinase.","authors":["Wernimont A.K.","Hutchinson A.","Lew J.","Chamberlain K.","MacKenzie F.","Loppnau P.","Cossar D.","Crombet L.","Arrowsmith C.H.","Edwards A.M.","Bountra C.","Weigelt J.","Hui R.","Amani M."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2013","submissionDatabase":"PDB data bank","title":"P. falciparum Calcium-Dependent Protein Kinase 2 (PfCDPK2): First Crystal Structure and Virtual Ligand Screening.","authors":["Lauciello L.","Pernot L.","Bottegoni G.","Bisson W.","Scapozza L.","Perozzo R."]}},{"source":"PDB","id":"3PM8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4MVF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2013","submissionDatabase":"PDB data bank","title":"P. falciparum Calcium-Dependent Protein Kinase 2 (PfCDPK2): First Crystal Structure and Virtual Ligand Screening.","authors":["Lauciello L.","Pernot L.","Bottegoni G.","Bisson W.","Scapozza L.","Perozzo R."]}},{"source":"PDB","id":"4MVF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
