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3PM0

Structural Characterization of the Complex between Alpha-Naphthoflavone and Human Cytochrome P450 1B1 (CYP1B1)

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0002930biological_processtrabecular meshwork development
A0004497molecular_functionmonooxygenase activity
A0005506molecular_functioniron ion binding
A0005515molecular_functionprotein binding
A0005739cellular_componentmitochondrion
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0006629biological_processlipid metabolic process
A0006631biological_processfatty acid metabolic process
A0006706biological_processsteroid catabolic process
A0006805biological_processxenobiotic metabolic process
A0006809biological_processnitric oxide biosynthetic process
A0007155biological_processcell adhesion
A0008202biological_processsteroid metabolic process
A0008210biological_processestrogen metabolic process
A0008285biological_processnegative regulation of cell population proliferation
A0008395molecular_functionsteroid hydroxylase activity
A0008631biological_processintrinsic apoptotic signaling pathway in response to oxidative stress
A0009404biological_processtoxin metabolic process
A0009636biological_processresponse to toxic substance
A0010575biological_processpositive regulation of vascular endothelial growth factor production
A0016020cellular_componentmembrane
A0016125biological_processsterol metabolic process
A0016491molecular_functionoxidoreductase activity
A0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A0016709molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
A0016712molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
A0016829molecular_functionlyase activity
A0019369biological_processarachidonate metabolic process
A0019373biological_processepoxygenase P450 pathway
A0020037molecular_functionheme binding
A0030199biological_processcollagen fibril organization
A0030336biological_processnegative regulation of cell migration
A0032088biological_processnegative regulation of NF-kappaB transcription factor activity
A0033629biological_processnegative regulation of cell adhesion mediated by integrin
A0042178biological_processxenobiotic catabolic process
A0042445biological_processhormone metabolic process
A0042537biological_processbenzene-containing compound metabolic process
A0042572biological_processretinol metabolic process
A0042574biological_processretinal metabolic process
A0043065biological_processpositive regulation of apoptotic process
A0043534biological_processblood vessel endothelial cell migration
A0043542biological_processendothelial cell migration
A0045766biological_processpositive regulation of angiogenesis
A0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
A0046466biological_processmembrane lipid catabolic process
A0046872molecular_functionmetal ion binding
A0048514biological_processblood vessel morphogenesis
A0050649molecular_functiontestosterone 6-beta-hydroxylase activity
A0061298biological_processretina vasculature development in camera-type eye
A0061304biological_processretinal blood vessel morphogenesis
A0070301biological_processcellular response to hydrogen peroxide
A0071407biological_processobsolete cellular response to organic cyclic compound
A0071603biological_processendothelial cell-cell adhesion
A0097267biological_processomega-hydroxylase P450 pathway
A0101020molecular_functionestrogen 16-alpha-hydroxylase activity
A0101021molecular_functionestrogen 2-hydroxylase activity
A0106256molecular_functionhydroperoxy icosatetraenoate dehydratase activity
A0120254biological_processolefinic compound metabolic process
A2000377biological_processregulation of reactive oxygen species metabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues25
DetailsBINDING SITE FOR RESIDUE HEM A 900
ChainResidue
AARG117
ATHR334
ALEU335
APHE394
AVAL395
ATHR398
AILE399
AHIS401
AGLN424
AILE462
APHE463
AMET132
ASER464
AARG468
ACYS470
AILE471
ASER476
ABHF800
AALA133
ATRP141
AARG145
AMET152
AILE327
AALA330
ASER331

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE BHF A 800
ChainResidue
APHE134
AASN228
APHE231
ALEU264
AASP326
AALA330
ATHR334
ALEU509
AHEM900

Functional Information from PROSITE/UniProt
site_idPS00086
Number of Residues10
DetailsCYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FSvGKRRCIG
ChainResidueDetails
APHE463-GLY472

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBINDING: axial binding residue => ECO:0000269|PubMed:21147782, ECO:0007744|PDB:3PM0
ChainResidueDetails
ACYS470

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Major determinant of CYP1B1 17beta-estradiol hydroxylation regiospecificity
ChainResidueDetails
AVAL395

237735

PDB entries from 2025-06-18

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