3PI8
Site-specific Glycosylation of Hemoglobin Utilizing Oxime Ligation Chemistry as a Viable Alternative to PEGylation
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004601 | molecular_function | peroxidase activity |
A | 0005344 | molecular_function | oxygen carrier activity |
A | 0005506 | molecular_function | iron ion binding |
A | 0005515 | molecular_function | protein binding |
A | 0005833 | cellular_component | hemoglobin complex |
A | 0015671 | biological_process | oxygen transport |
A | 0019825 | molecular_function | oxygen binding |
A | 0020037 | molecular_function | heme binding |
A | 0031720 | molecular_function | haptoglobin binding |
A | 0031838 | cellular_component | haptoglobin-hemoglobin complex |
A | 0042744 | biological_process | hydrogen peroxide catabolic process |
A | 0043177 | molecular_function | organic acid binding |
A | 0046872 | molecular_function | metal ion binding |
A | 0098869 | biological_process | cellular oxidant detoxification |
B | 0004601 | molecular_function | peroxidase activity |
B | 0005344 | molecular_function | oxygen carrier activity |
B | 0005833 | cellular_component | hemoglobin complex |
B | 0015671 | biological_process | oxygen transport |
B | 0019825 | molecular_function | oxygen binding |
B | 0020037 | molecular_function | heme binding |
B | 0031720 | molecular_function | haptoglobin binding |
B | 0031721 | molecular_function | hemoglobin alpha binding |
B | 0031838 | cellular_component | haptoglobin-hemoglobin complex |
B | 0042744 | biological_process | hydrogen peroxide catabolic process |
B | 0043177 | molecular_function | organic acid binding |
B | 0046872 | molecular_function | metal ion binding |
B | 0098869 | biological_process | cellular oxidant detoxification |
C | 0004601 | molecular_function | peroxidase activity |
C | 0005344 | molecular_function | oxygen carrier activity |
C | 0005506 | molecular_function | iron ion binding |
C | 0005515 | molecular_function | protein binding |
C | 0005833 | cellular_component | hemoglobin complex |
C | 0015671 | biological_process | oxygen transport |
C | 0019825 | molecular_function | oxygen binding |
C | 0020037 | molecular_function | heme binding |
C | 0031720 | molecular_function | haptoglobin binding |
C | 0031838 | cellular_component | haptoglobin-hemoglobin complex |
C | 0042744 | biological_process | hydrogen peroxide catabolic process |
C | 0043177 | molecular_function | organic acid binding |
C | 0046872 | molecular_function | metal ion binding |
C | 0098869 | biological_process | cellular oxidant detoxification |
D | 0004601 | molecular_function | peroxidase activity |
D | 0005344 | molecular_function | oxygen carrier activity |
D | 0005833 | cellular_component | hemoglobin complex |
D | 0015671 | biological_process | oxygen transport |
D | 0019825 | molecular_function | oxygen binding |
D | 0020037 | molecular_function | heme binding |
D | 0031720 | molecular_function | haptoglobin binding |
D | 0031721 | molecular_function | hemoglobin alpha binding |
D | 0031838 | cellular_component | haptoglobin-hemoglobin complex |
D | 0042744 | biological_process | hydrogen peroxide catabolic process |
D | 0043177 | molecular_function | organic acid binding |
D | 0046872 | molecular_function | metal ion binding |
D | 0098869 | biological_process | cellular oxidant detoxification |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE HEM A 142 |
Chain | Residue |
A | TYR42 |
A | ASN97 |
A | PHE98 |
A | LEU101 |
A | LEU136 |
A | CMO143 |
A | HOH433 |
A | PHE43 |
A | HIS45 |
A | HIS58 |
A | LYS61 |
A | LEU83 |
A | LEU86 |
A | HIS87 |
A | LEU91 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CMO A 143 |
Chain | Residue |
A | LEU29 |
A | PHE43 |
A | HIS58 |
A | VAL62 |
A | HEM142 |
site_id | AC3 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE HEM B 147 |
Chain | Residue |
B | THR38 |
B | PHE41 |
B | HIS63 |
B | LYS66 |
B | SER70 |
B | LEU88 |
B | HIS92 |
B | LEU96 |
B | ASN102 |
B | PHE103 |
B | CMO148 |
B | HOH154 |
B | HOH172 |
site_id | AC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CMO B 148 |
Chain | Residue |
B | LEU28 |
B | PHE42 |
B | HIS63 |
B | VAL67 |
B | HEM147 |
site_id | AC5 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE HEM C 142 |
Chain | Residue |
A | ALA12 |
A | LYS16 |
C | TYR42 |
C | HIS45 |
C | HIS58 |
C | LYS61 |
C | LEU83 |
C | LEU86 |
C | HIS87 |
C | LEU91 |
C | VAL93 |
C | ASN97 |
C | PHE98 |
C | LEU101 |
C | CMO143 |
C | HOH163 |
site_id | AC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CMO C 143 |
Chain | Residue |
C | LEU29 |
C | PHE43 |
C | HIS58 |
C | VAL62 |
C | HEM142 |
site_id | AC7 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE HEM D 147 |
Chain | Residue |
D | PHE41 |
D | PHE42 |
D | HIS63 |
D | VAL67 |
D | SER70 |
D | PHE71 |
D | LEU88 |
D | LEU91 |
D | HIS92 |
D | LEU96 |
D | VAL98 |
D | ASN102 |
D | PHE103 |
D | LEU106 |
D | LEU141 |
D | CMO148 |
site_id | AC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CMO D 148 |
Chain | Residue |
D | LEU28 |
D | HIS63 |
D | VAL67 |
D | HEM147 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | BINDING: distal binding residue |
Chain | Residue | Details |
B | HIS63 | |
D | HIS63 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: proximal binding residue |
Chain | Residue | Details |
B | HIS92 | |
D | HIS92 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P68871 |
Chain | Residue | Details |
B | THR12 | |
D | THR12 | |
A | SER49 | |
C | SER3 | |
C | SER35 | |
C | SER49 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P68871 |
Chain | Residue | Details |
B | SER44 | |
D | SER44 | |
A | LYS40 | |
C | LYS7 | |
C | LYS11 | |
C | LYS40 |
site_id | SWS_FT_FI5 |
Number of Residues | 4 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P68871 |
Chain | Residue | Details |
B | LYS59 | |
B | LYS82 | |
D | LYS59 | |
D | LYS82 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:P68871 |
Chain | Residue | Details |
B | CYS93 | |
D | CYS93 |
site_id | SWS_FT_FI7 |
Number of Residues | 6 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P01942 |
Chain | Residue | Details |
A | SER102 | |
A | SER124 | |
A | SER138 | |
C | SER102 | |
C | SER124 | |
C | SER138 |
site_id | SWS_FT_FI8 |
Number of Residues | 6 |
Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P01942 |
Chain | Residue | Details |
A | THR108 | |
A | THR134 | |
A | THR137 | |
C | THR108 | |
C | THR134 | |
C | THR137 |