3PHX
OTU Domain of Crimean Congo Hemorrhagic Fever Virus in complex with ISG15
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 184 |
| Chain | Residue |
| A | HIS43 |
| A | LYS53 |
| A | ASP55 |
| A | SER57 |
| A | TYR58 |
| A | HOH318 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN A 185 |
| Chain | Residue |
| A | HIS59 |
| A | HOH255 |
| A | HOH268 |
| A | SER6 |
| A | ASP8 |
| A | HIS56 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 186 |
| Chain | Residue |
| A | ASP8 |
| A | ASP96 |
| A | ACY193 |
| A | HOH262 |
| A | HOH266 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN A 187 |
| Chain | Residue |
| A | ASN24 |
| A | GLU126 |
| A | HOH320 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 188 |
| Chain | Residue |
| A | HIS151 |
| A | ASP153 |
| A | HOH258 |
| A | HOH259 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 189 |
| Chain | Residue |
| A | ASP88 |
| A | HOH234 |
| A | HOH330 |
| A | HOH331 |
| B | GLU127 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ZN A 190 |
| Chain | Residue |
| A | GLU47 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 191 |
| Chain | Residue |
| A | PRO35 |
| A | ASP37 |
| A | HIS43 |
| A | ACY193 |
| A | HOH254 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 192 |
| Chain | Residue |
| A | GLY-1 |
| A | ASP2 |
| A | ASP55 |
| A | HOH270 |
| site_id | BC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE ACY A 193 |
| Chain | Residue |
| A | ASP8 |
| A | ASP37 |
| A | ASN39 |
| A | HIS43 |
| A | HIS56 |
| A | TYR58 |
| A | ASP96 |
| A | ZN186 |
| A | ZN191 |
| A | HOH266 |
| A | HOH268 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NEH B 157 |
| Chain | Residue |
| A | ASP37 |
| A | CYS40 |
| A | TRP99 |
| A | THR150 |
| B | GLY156 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ZN B 1 |
| Chain | Residue |
| B | HIS106 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ZN B 2 |
| Chain | Residue |
| B | HIS106 |
| B | GLN109 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN B 3 |
| Chain | Residue |
| B | ACY4 |
| B | ASP119 |
| B | HOH240 |
| site_id | BC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACY B 4 |
| Chain | Residue |
| B | ZN3 |
| B | ASP119 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 27 |
| Details | Region: {"description":"Essential for the vOTU enzymatic activity","evidences":[{"source":"PubMed","id":"21266548","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"For ubiquitin thioesterase activity","evidences":[{"source":"PubMed","id":"21228232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21266548","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"description":"For ubiquitin thioesterase activity","evidences":[{"source":"PubMed","id":"21228232","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21266548","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18078692","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Interacts with activating enzyme","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
