3PH7

Crystal structure of Plasmodium vivax putative polyprenyl pyrophosphate synthase in complex with geranylgeranyl diphosphate

Replaces:  3MYS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004161	molecular_function	dimethylallyltranstransferase activity
A	0004337	molecular_function	(2E,6E)-farnesyl diphosphate synthase activity
A	0004659	molecular_function	prenyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0008299	biological_process	isoprenoid biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
A	0045337	biological_process	farnesyl diphosphate biosynthetic process
A	0046872	molecular_function	metal ion binding
B	0004161	molecular_function	dimethylallyltranstransferase activity
B	0004337	molecular_function	(2E,6E)-farnesyl diphosphate synthase activity
B	0004659	molecular_function	prenyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0008299	biological_process	isoprenoid biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
B	0045337	biological_process	farnesyl diphosphate biosynthetic process
B	0046872	molecular_function	metal ion binding
C	0004161	molecular_function	dimethylallyltranstransferase activity
C	0004337	molecular_function	(2E,6E)-farnesyl diphosphate synthase activity
C	0004659	molecular_function	prenyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0008299	biological_process	isoprenoid biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
C	0045337	biological_process	farnesyl diphosphate biosynthetic process
C	0046872	molecular_function	metal ion binding
D	0004161	molecular_function	dimethylallyltranstransferase activity
D	0004337	molecular_function	(2E,6E)-farnesyl diphosphate synthase activity
D	0004659	molecular_function	prenyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0008299	biological_process	isoprenoid biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
D	0045337	biological_process	farnesyl diphosphate biosynthetic process
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	22
Details	BINDING SITE FOR RESIDUE GRG A 1502

Chain	Residue
A	GLY80
A	ARG136
A	VAL156
A	THR188
A	THR191
A	ILE192
A	GLN195
A	LYS243
A	TYR247
A	PHE283
A	HOH405
A	LYS81
A	HOH407
B	ASN154
B	LEU157
A	ARG84
A	GLN119
A	PHE122
A	LEU123
A	ALA125
A	MET129
A	ARG135

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site_id	AC2
Number of Residues	22
Details	BINDING SITE FOR RESIDUE GRG B 1502

Chain	Residue
A	ASN154
A	LEU157
B	GLY80
B	LYS81
B	ARG84
B	GLN119
B	ALA121
B	PHE122
B	LEU123
B	MET129
B	ARG135
B	ARG136
B	VAL156
B	THR188
B	THR191
B	ILE192
B	GLN195
B	LYS243
B	TYR247
B	PHE283
B	HOH404
B	HOH408

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site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE GRG C 1502

Chain	Residue
C	GLY80
C	LYS81
C	ARG84
C	GLN119
C	PHE122
C	ALA125
C	MET129
C	ARG135
C	ARG136
C	THR191
C	ILE192
C	GLN195
C	LYS243
C	TYR247
C	PHE283
C	HOH400
D	ASN154
D	LEU157

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site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GRG D 1502

Chain	Residue
C	ASN154
C	LEU157
D	GLY80
D	LYS81
D	ARG84
D	GLN119
D	PHE122
D	LEU123
D	MET129
D	ARG135
D	ARG136
D	THR188
D	THR191
D	GLN195
D	PHE283

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Functional Information from PROSITE/UniProt

site_id	PS00444
Number of Residues	13
Details	POLYPRENYL_SYNTHASE_2 Polyprenyl synthases signature 2. MGeyFQIhDDYlD

Chain	Residue	Details
A	MET279-ASP291

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