3PH7
Crystal structure of Plasmodium vivax putative polyprenyl pyrophosphate synthase in complex with geranylgeranyl diphosphate
Replaces: 3MYSFunctional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004659 | molecular_function | prenyltransferase activity |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004659 | molecular_function | prenyltransferase activity |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0004659 | molecular_function | prenyltransferase activity |
| C | 0008299 | biological_process | isoprenoid biosynthetic process |
| C | 0016020 | cellular_component | membrane |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0004659 | molecular_function | prenyltransferase activity |
| D | 0008299 | biological_process | isoprenoid biosynthetic process |
| D | 0016020 | cellular_component | membrane |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE GRG A 1502 |
| Chain | Residue |
| A | GLY80 |
| A | ARG136 |
| A | VAL156 |
| A | THR188 |
| A | THR191 |
| A | ILE192 |
| A | GLN195 |
| A | LYS243 |
| A | TYR247 |
| A | PHE283 |
| A | HOH405 |
| A | LYS81 |
| A | HOH407 |
| B | ASN154 |
| B | LEU157 |
| A | ARG84 |
| A | GLN119 |
| A | PHE122 |
| A | LEU123 |
| A | ALA125 |
| A | MET129 |
| A | ARG135 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE GRG B 1502 |
| Chain | Residue |
| A | ASN154 |
| A | LEU157 |
| B | GLY80 |
| B | LYS81 |
| B | ARG84 |
| B | GLN119 |
| B | ALA121 |
| B | PHE122 |
| B | LEU123 |
| B | MET129 |
| B | ARG135 |
| B | ARG136 |
| B | VAL156 |
| B | THR188 |
| B | THR191 |
| B | ILE192 |
| B | GLN195 |
| B | LYS243 |
| B | TYR247 |
| B | PHE283 |
| B | HOH404 |
| B | HOH408 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE GRG C 1502 |
| Chain | Residue |
| C | GLY80 |
| C | LYS81 |
| C | ARG84 |
| C | GLN119 |
| C | PHE122 |
| C | ALA125 |
| C | MET129 |
| C | ARG135 |
| C | ARG136 |
| C | THR191 |
| C | ILE192 |
| C | GLN195 |
| C | LYS243 |
| C | TYR247 |
| C | PHE283 |
| C | HOH400 |
| D | ASN154 |
| D | LEU157 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE GRG D 1502 |
| Chain | Residue |
| C | ASN154 |
| C | LEU157 |
| D | GLY80 |
| D | LYS81 |
| D | ARG84 |
| D | GLN119 |
| D | PHE122 |
| D | LEU123 |
| D | MET129 |
| D | ARG135 |
| D | ARG136 |
| D | THR188 |
| D | THR191 |
| D | GLN195 |
| D | PHE283 |
Functional Information from PROSITE/UniProt
| site_id | PS00444 |
| Number of Residues | 13 |
| Details | POLYPRENYL_SYNTHASE_2 Polyprenyl synthases signature 2. MGeyFQIhDDYlD |
| Chain | Residue | Details |
| A | MET279-ASP291 |
