3PE4

Structure of human O-GlcNAc transferase and its complex with a peptide substrate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006493	biological_process	protein O-linked glycosylation
A	0016757	molecular_function	glycosyltransferase activity
C	0006493	biological_process	protein O-linked glycosylation
C	0016757	molecular_function	glycosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	BINDING SITE FOR RESIDUE UDP A 1212

Chain	Residue
A	HOH4
A	ARG904
A	HIS920
A	THR921
A	THR922
A	ASP925
A	HOH1064
A	HOH1087
B	THR18
B	VAL20
B	SER21
A	PRO559
B	HOH27
B	HOH57
A	GLN839
A	LYS842
A	LEU866
A	VAL895
A	ALA896
A	LYS898
A	HIS901

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 5

Chain	Residue
A	GLY365
A	LYS366
A	LEU367
A	GLN368
A	HOH1070

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 1

Chain	Residue
A	GLY635
A	HOH1103
B	ASN24
B	MET25

---

site_id	AC4
Number of Residues	22
Details	BINDING SITE FOR RESIDUE UDP C 1212

Chain	Residue
C	HOH9
C	PRO559
C	GLN839
C	LYS842
C	LEU866
C	VAL895
C	ALA896
C	LYS898
C	HIS901
C	ARG904
C	HIS920
C	THR921
C	THR922
C	ASP925
C	HOH1060
C	HOH1086
C	HOH1254
D	THR18
D	VAL20
D	SER21
D	HOH32
D	HOH98

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 3

Chain	Residue
C	GLY635
C	HOH1182
D	ASN24
D	MET25

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by CDK1 => ECO:0000269|PubMed:7592773

Chain	Residue	Details
B	THR18
D	THR18

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:23103939, ECO:0007744|PDB:4GYW

Chain	Residue	Details
A	GLN839
C	HIS901
C	HIS920
C	ASP925
A	LYS842
A	ALA896
A	HIS901
A	HIS920
A	ASP925
C	GLN839
C	LYS842
C	ALA896

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by AMPK => ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:37541260

Chain	Residue	Details
A	THR444
C	THR444

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P56558

Chain	Residue	Details
A	TYR979
C	TYR979

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	CARBOHYD: O-linked (GlcNAc) serine; by autocatalysis => ECO:0000269|PubMed:27713473

Chain	Residue	Details
A	SER389
C	SER389

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