3PE3
Structure of human O-GlcNAc transferase and its complex with a peptide substrate
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006493 | biological_process | protein O-linked glycosylation |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0006493 | biological_process | protein O-linked glycosylation |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| C | 0006493 | biological_process | protein O-linked glycosylation |
| C | 0016757 | molecular_function | glycosyltransferase activity |
| D | 0006493 | biological_process | protein O-linked glycosylation |
| D | 0016757 | molecular_function | glycosyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE UDP A 1201 |
| Chain | Residue |
| A | HOH14 |
| A | LYS898 |
| A | HIS901 |
| A | ARG904 |
| A | GLY919 |
| A | HIS920 |
| A | THR921 |
| A | THR922 |
| A | ASP925 |
| A | HOH136 |
| A | HOH248 |
| A | HOH261 |
| A | GLN839 |
| A | LYS842 |
| A | LEU866 |
| A | VAL895 |
| A | ALA896 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE UDP B 1201 |
| Chain | Residue |
| B | HOH1 |
| B | HOH16 |
| B | PRO559 |
| B | GLN839 |
| B | LYS842 |
| B | LEU866 |
| B | VAL895 |
| B | ALA896 |
| B | LYS898 |
| B | HIS901 |
| B | ARG904 |
| B | HIS920 |
| B | THR921 |
| B | THR922 |
| B | ASP925 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE UDP C 1201 |
| Chain | Residue |
| C | HOH262 |
| C | PRO559 |
| C | GLN839 |
| C | LYS842 |
| C | LEU866 |
| C | VAL895 |
| C | ALA896 |
| C | LYS898 |
| C | HIS901 |
| C | ARG904 |
| C | HIS920 |
| C | THR921 |
| C | THR922 |
| C | ASP925 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE UDP D 1201 |
| Chain | Residue |
| D | HOH4 |
| D | HOH73 |
| D | ASN838 |
| D | GLN839 |
| D | LYS842 |
| D | LEU866 |
| D | VAL895 |
| D | ALA896 |
| D | LYS898 |
| D | HIS901 |
| D | ARG904 |
| D | HIS920 |
| D | THR921 |
| D | THR922 |
| D | ASP925 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:21240259, ECO:0000305|PubMed:26678539 |
| Chain | Residue | Details |
| A | HIS498 | |
| B | HIS498 | |
| C | HIS498 | |
| D | HIS498 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:23103939, ECO:0007744|PDB:4GYW |
| Chain | Residue | Details |
| A | GLN839 | |
| B | HIS901 | |
| B | HIS920 | |
| B | ASP925 | |
| C | GLN839 | |
| C | LYS842 | |
| C | ALA896 | |
| C | HIS901 | |
| C | HIS920 | |
| C | ASP925 | |
| D | GLN839 | |
| A | LYS842 | |
| D | LYS842 | |
| D | ALA896 | |
| D | HIS901 | |
| D | HIS920 | |
| D | ASP925 | |
| A | ALA896 | |
| A | HIS901 | |
| A | HIS920 | |
| A | ASP925 | |
| B | GLN839 | |
| B | LYS842 | |
| B | ALA896 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphothreonine; by AMPK => ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:37541260 |
| Chain | Residue | Details |
| A | THR444 | |
| B | THR444 | |
| C | THR444 | |
| D | THR444 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P56558 |
| Chain | Residue | Details |
| A | TYR979 | |
| B | TYR979 | |
| C | TYR979 | |
| D | TYR979 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | CARBOHYD: O-linked (GlcNAc) serine; by autocatalysis => ECO:0000269|PubMed:27713473 |
| Chain | Residue | Details |
| A | SER389 | |
| B | SER389 | |
| C | SER389 | |
| D | SER389 |
