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3PD9

X-ray structure of the ligand-binding core of GluA2 in complex with (R)-5-HPCA at 2.1 A resolution

Functional Information from GO Data
ChainGOidnamespacecontents
A0015276molecular_functionligand-gated monoatomic ion channel activity
A0016020cellular_componentmembrane
B0015276molecular_functionligand-gated monoatomic ion channel activity
B0016020cellular_componentmembrane
Functional Information from PDB Data
site_idAC1
Number of Residues11
DetailsBINDING SITE FOR RESIDUE HA5 A 260
ChainResidue
ATYR58
AMET193
AHOH343
APRO86
ALEU87
ATHR88
AARG93
AGLY138
ASER139
ATHR140
AGLU190

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 261
ChainResidue
AARG28
AHOH278
AHOH333
AHOH431
BLYS180

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 262
ChainResidue
AARG145
ATRP156
AARG160

site_idAC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 263
ChainResidue
AARG28
ALYS49
AHOH378

site_idAC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL A 264
ChainResidue
ALYS113
ALYS182
AHOH322

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE GOL A 265
ChainResidue
AVAL96
AGLY115
AHOH370

site_idAC7
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CL A 266
ChainResidue
AARG160

site_idAC8
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL A 267
ChainResidue
AHIS43
AGLN241

site_idAC9
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL A 268
ChainResidue
AASP136
ALYS141
AHOH476

site_idBC1
Number of Residues12
DetailsBINDING SITE FOR RESIDUE HA5 B 260
ChainResidue
BTYR58
BPRO86
BLEU87
BTHR88
BARG93
BGLY138
BSER139
BTHR140
BGLU190
BMET193
BHOH277
BHOH288

site_idBC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 B 261
ChainResidue
BTRP156
BARG160
BHOH275

site_idBC3
Number of Residues8
DetailsBINDING SITE FOR RESIDUE GOL B 262
ChainResidue
BALA60
BASP136
BSER137
BGLY138
BLYS141
BGLU142
BARG145
BHOH388

site_idBC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL B 263
ChainResidue
APRO102
ALEU236
AASN239
BILE89
BPRO102
BLYS215
BGLY216

site_idBC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE GOL B 264
ChainResidue
BVAL96
BGLY115
BPRO117
BHOH471

site_idBC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL B 265
ChainResidue
BHIS43
BLYS237
BGLN241

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO
ChainResidueDetails
APRO86
BSER139
BTHR140
BGLU190
ATHR88
AARG93
ASER139
ATHR140
AGLU190
BPRO86
BTHR88
BARG93

site_idSWS_FT_FI2
Number of Residues6
DetailsSITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405
ChainResidueDetails
AARG61
AARG145
ALYS237
BARG61
BARG145
BLYS237

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405
ChainResidueDetails
AILE118
BILE118

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293
ChainResidueDetails
ASER147
BSER147

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293
ChainResidueDetails
ASER181
BSER181

site_idSWS_FT_FI6
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN0
BASN0

227344

PDB entries from 2024-11-13

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