3PC4
Full length structure of cystathionine beta-synthase from Drosophila in complex with serine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004122 | molecular_function | cystathionine beta-synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006535 | biological_process | cysteine biosynthetic process from serine |
| A | 0008340 | biological_process | determination of adult lifespan |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016829 | molecular_function | lyase activity |
| A | 0019343 | biological_process | cysteine biosynthetic process via cystathionine |
| A | 0019344 | biological_process | cysteine biosynthetic process |
| A | 0034976 | biological_process | response to endoplasmic reticulum stress |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050421 | molecular_function | nitrite reductase (NO-forming) activity |
| A | 0050667 | biological_process | homocysteine metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE HEM A 701 |
| Chain | Residue |
| A | SER20 |
| A | ARG193 |
| A | ALA195 |
| A | PRO198 |
| A | LEU199 |
| A | TYR202 |
| A | ARG235 |
| A | THR282 |
| A | HOH820 |
| A | LYS21 |
| A | CYS22 |
| A | LYS23 |
| A | TRP24 |
| A | THR28 |
| A | GLU30 |
| A | PRO33 |
| A | HIS34 |
| site_id | AC2 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE KOU A 702 |
| Chain | Residue |
| A | LYS88 |
| A | THR115 |
| A | SER116 |
| A | ASN118 |
| A | THR119 |
| A | GLN191 |
| A | ALA224 |
| A | GLY225 |
| A | THR226 |
| A | ALA227 |
| A | GLY228 |
| A | THR229 |
| A | GLY274 |
| A | ILE275 |
| A | TYR277 |
| A | SER318 |
| A | PRO344 |
| A | ASP345 |
| A | HOH623 |
| A | HOH631 |
| A | HOH667 |
| A | HOH917 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 703 |
| Chain | Residue |
| A | HIS324 |
| A | HOH561 |
| A | HOH589 |
| A | HOH867 |
Functional Information from PROSITE/UniProt
| site_id | PS00901 |
| Number of Residues | 19 |
| Details | CYS_SYNTHASE Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. KcEfln.PGgSVKdRiGyrM |
| Chain | Residue | Details |
| A | LYS77-MET95 |
