3PB0

Characterisation of the first monomeric dihydrodipicolinate synthase variant reveals evolutionary insights

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
A	0009089	biological_process	obsolete L-lysine biosynthetic process via diaminopimelate
A	0016829	molecular_function	lyase activity
A	0019877	biological_process	obsolete diaminopimelate biosynthetic process
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
B	0009089	biological_process	obsolete L-lysine biosynthetic process via diaminopimelate
B	0016829	molecular_function	lyase activity
B	0019877	biological_process	obsolete diaminopimelate biosynthetic process
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
C	0009089	biological_process	obsolete L-lysine biosynthetic process via diaminopimelate
C	0016829	molecular_function	lyase activity
C	0019877	biological_process	obsolete diaminopimelate biosynthetic process
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0008840	molecular_function	4-hydroxy-tetrahydrodipicolinate synthase activity
D	0009089	biological_process	obsolete L-lysine biosynthetic process via diaminopimelate
D	0016829	molecular_function	lyase activity
D	0019877	biological_process	obsolete diaminopimelate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE SO4 A 295

Chain	Residue
A	ALA166
C	ALA167
C	HOH340
A	ALA167
A	ARG193
A	HOH309
A	HOH353
A	HOH377
A	HOH556
A	HOH791
C	ALA166

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 C 295

Chain	Residue
C	THR78
C	ASN79
C	LYS83
C	TYR105
C	TYR106
C	HOH362
C	HOH385
C	HOH703

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D 295

Chain	Residue
D	ALA166
D	ALA167
D	ARG193
D	HOH756
D	HOH812
D	HOH1001

---

Functional Information from PROSITE/UniProt

site_id	PS00665
Number of Residues	18
Details	DHDPS_1 Dihydrodipicolinate synthase signature 1. ALIvlGTTGESptvnedE

Chain	Residue	Details
A	ALA37-GLU54

---

site_id	PS00666
Number of Residues	32
Details	DHDPS_2 Dihydrodipicolinate synthase signature 2. YNVPgrTgvnVlpetaariaadlknVvGIKEA

Chain	Residue	Details
A	TYR132-ALA163

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00418","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Schiff-base intermediate with substrate","evidences":[{"source":"HAMAP-Rule","id":"MF_00418","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00418","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Site: {"description":"Part of a proton relay during catalysis","evidences":[{"source":"HAMAP-Rule","id":"MF_00418","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---