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3P8C

Structure and Control of the Actin Regulatory WAVE Complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000340molecular_functionRNA 7-methylguanosine cap binding
A0000902biological_processcell morphogenesis
A0001726cellular_componentruffle
A0003779molecular_functionactin binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005925cellular_componentfocal adhesion
A0006417biological_processregulation of translation
A0007399biological_processnervous system development
A0007411biological_processaxon guidance
A0008360biological_processregulation of cell shape
A0010592biological_processpositive regulation of lamellipodium assembly
A0016601biological_processRac protein signal transduction
A0017148biological_processnegative regulation of translation
A0030027cellular_componentlamellipodium
A0030032biological_processlamellipodium assembly
A0030154biological_processcell differentiation
A0030371molecular_functiontranslation repressor activity
A0030833biological_processregulation of actin filament polymerization
A0031175biological_processneuron projection development
A0031209cellular_componentSCAR complex
A0031267molecular_functionsmall GTPase binding
A0031529biological_processruffle organization
A0031641biological_processregulation of myelination
A0032433cellular_componentfilopodium tip
A0032869biological_processcellular response to insulin stimulus
A0034774cellular_componentsecretory granule lumen
A0035580cellular_componentspecific granule lumen
A0042995cellular_componentcell projection
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043195cellular_componentterminal bouton
A0043197cellular_componentdendritic spine
A0044294cellular_componentdendritic growth cone
A0044295cellular_componentaxonal growth cone
A0045202cellular_componentsynapse
A0045773biological_processpositive regulation of axon extension
A0048471cellular_componentperinuclear region of cytoplasm
A0048675biological_processaxon extension
A0050772biological_processpositive regulation of axonogenesis
A0050890biological_processcognition
A0051015molecular_functionactin filament binding
A0051388biological_processpositive regulation of neurotrophin TRK receptor signaling pathway
A0051602biological_processresponse to electrical stimulus
A0060076cellular_componentexcitatory synapse
A0070062cellular_componentextracellular exosome
A0090724cellular_componentcentral region of growth cone
A0090725cellular_componentperipheral region of growth cone
A0097484biological_processdendrite extension
A0098794cellular_componentpostsynapse
A0099563biological_processmodification of synaptic structure
A0099578biological_processregulation of translation at postsynapse, modulating synaptic transmission
A1900006biological_processpositive regulation of dendrite development
A1900029biological_processpositive regulation of ruffle assembly
A1903422biological_processnegative regulation of synaptic vesicle recycling
A1904724cellular_componenttertiary granule lumen
A1905274biological_processregulation of modification of postsynaptic actin cytoskeleton
A2000601biological_processpositive regulation of Arp2/3 complex-mediated actin nucleation
B0000902biological_processcell morphogenesis
B0001726cellular_componentruffle
B0005515molecular_functionprotein binding
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0006915biological_processapoptotic process
B0007417biological_processcentral nervous system development
B0010592biological_processpositive regulation of lamellipodium assembly
B0016020cellular_componentmembrane
B0016477biological_processcell migration
B0016601biological_processRac protein signal transduction
B0030027cellular_componentlamellipodium
B0030031biological_processcell projection assembly
B0030838biological_processpositive regulation of actin filament polymerization
B0030866biological_processcortical actin cytoskeleton organization
B0031209cellular_componentSCAR complex
B0031258cellular_componentlamellipodium membrane
B0031267molecular_functionsmall GTPase binding
B0031941cellular_componentfilamentous actin
B0042995cellular_componentcell projection
B0048812biological_processneuron projection morphogenesis
B0070062cellular_componentextracellular exosome
B2000601biological_processpositive regulation of Arp2/3 complex-mediated actin nucleation
D0003779molecular_functionactin binding
D0005856cellular_componentcytoskeleton
D0030036biological_processactin cytoskeleton organization
E0001701biological_processin utero embryonic development
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005856cellular_componentcytoskeleton
E0007015biological_processactin filament organization
E0008064biological_processregulation of actin polymerization or depolymerization
E0010592biological_processpositive regulation of lamellipodium assembly
E0016601biological_processRac protein signal transduction
E0030027cellular_componentlamellipodium
E0030036biological_processactin cytoskeleton organization
E0031209cellular_componentSCAR complex
E0031267molecular_functionsmall GTPase binding
E0031334biological_processpositive regulation of protein-containing complex assembly
E0042802molecular_functionidentical protein binding
E0044877molecular_functionprotein-containing complex binding
E0048144biological_processfibroblast proliferation
E0048146biological_processpositive regulation of fibroblast proliferation
E0048870biological_processcell motility
E0070062cellular_componentextracellular exosome
E2000601biological_processpositive regulation of Arp2/3 complex-mediated actin nucleation
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE TRS A 1254
ChainResidue
ATYR967
APHE975
AHOH1662
AHOH1663

site_idAC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE CL A 1258
ChainResidue
AARG786
AGLU797

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL A 1259
ChainResidue
ATYR318
ATHR321
AGLU173
ATHR221
AARG317

site_idAC4
Number of Residues2
DetailsBINDING SITE FOR RESIDUE GOL A 1260
ChainResidue
AASP689
DTYR125

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL A 1261
ChainResidue
ATHR769
AGLN770
ATHR817
AHOH1311
AHOH1447
EARG59

site_idAC6
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CL B 1129
ChainResidue
BHIS590

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL B 1131
ChainResidue
BARG340
BARG343
BPHE400
BHOH1133

site_idAC8
Number of Residues2
DetailsBINDING SITE FOR RESIDUE GOL B 1132
ChainResidue
BHIS700
FILE124

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues20
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
BILE995-MET1015

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: N-acetylserine => ECO:0007744|PubMed:19413330
ChainResidueDetails
BSER2

218853

PDB entries from 2024-04-24

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