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3P2D

Crystal structure of arrestin-3 reveals the basis of the difference in receptor binding between two non-visual subtypes

Functional Information from GO Data
ChainGOidnamespacecontents
A0000822molecular_functioninositol hexakisphosphate binding
A0001664molecular_functionG protein-coupled receptor binding
A0002029biological_processdesensitization of G protein-coupled receptor signaling pathway
A0002031biological_processG protein-coupled receptor internalization
A0002092biological_processpositive regulation of receptor internalization
A0005547molecular_functionphosphatidylinositol-3,4,5-trisphosphate binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005886cellular_componentplasma membrane
A0005905cellular_componentclathrin-coated pit
A0006898biological_processreceptor-mediated endocytosis
A0007165biological_processsignal transduction
A0008277biological_processregulation of G protein-coupled receptor signaling pathway
A0009968biological_processnegative regulation of signal transduction
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0019233biological_processsensory perception of pain
A0030139cellular_componentendocytic vesicle
A0031410cellular_componentcytoplasmic vesicle
A0031623biological_processreceptor internalization
A0031701molecular_functionangiotensin receptor binding
A0031748molecular_functionD1 dopamine receptor binding
A0035091molecular_functionphosphatidylinositol binding
A0050804biological_processmodulation of chemical synaptic transmission
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
B0000822molecular_functioninositol hexakisphosphate binding
B0001664molecular_functionG protein-coupled receptor binding
B0002029biological_processdesensitization of G protein-coupled receptor signaling pathway
B0002031biological_processG protein-coupled receptor internalization
B0002092biological_processpositive regulation of receptor internalization
B0005547molecular_functionphosphatidylinositol-3,4,5-trisphosphate binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005886cellular_componentplasma membrane
B0005905cellular_componentclathrin-coated pit
B0006898biological_processreceptor-mediated endocytosis
B0007165biological_processsignal transduction
B0008277biological_processregulation of G protein-coupled receptor signaling pathway
B0009968biological_processnegative regulation of signal transduction
B0015031biological_processprotein transport
B0016020cellular_componentmembrane
B0019233biological_processsensory perception of pain
B0030139cellular_componentendocytic vesicle
B0031410cellular_componentcytoplasmic vesicle
B0031623biological_processreceptor internalization
B0031701molecular_functionangiotensin receptor binding
B0031748molecular_functionD1 dopamine receptor binding
B0035091molecular_functionphosphatidylinositol binding
B0050804biological_processmodulation of chemical synaptic transmission
B0070374biological_processpositive regulation of ERK1 and ERK2 cascade
Functional Information from PROSITE/UniProt
site_idPS00295
Number of Residues19
DetailsARRESTINS Arrestins signature. FRYGrEDlDVLGLsFrKDL
ChainResidueDetails
APHE62-LEU80

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q91YI4
ChainResidueDetails
ATYR48
BTYR48

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Hydroxyproline; by PHD2 => ECO:0000250
ChainResidueDetails
APRO176
APRO181
BPRO176
BPRO181

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P29067
ChainResidueDetails
ASER360
BSER360

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P29067
ChainResidueDetails
AARG393
BARG393

237992

PDB entries from 2025-06-25

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