3P0F
Structure of hUPP2 in an inactive conformation with bound 5-benzylacyclouridine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004850 | molecular_function | uridine phosphorylase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006218 | biological_process | uridine catabolic process |
| A | 0006248 | biological_process | CMP catabolic process |
| A | 0006249 | biological_process | dCMP catabolic process |
| A | 0009032 | molecular_function | thymidine phosphorylase activity |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0009166 | biological_process | nucleotide catabolic process |
| A | 0016154 | molecular_function | pyrimidine-nucleoside phosphorylase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0042178 | biological_process | xenobiotic catabolic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0044206 | biological_process | UMP salvage |
| A | 0045098 | cellular_component | type III intermediate filament |
| A | 0046050 | biological_process | UMP catabolic process |
| A | 0046074 | biological_process | dTMP catabolic process |
| A | 0046079 | biological_process | dUMP catabolic process |
| A | 0046108 | biological_process | uridine metabolic process |
| A | 0047847 | molecular_function | deoxyuridine phosphorylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE BAU A 400 |
| Chain | Residue |
| A | HIS42 |
| A | GLU254 |
| A | MET255 |
| A | ASP285 |
| A | ILE287 |
| A | HOH407 |
| A | HOH465 |
| A | HOH486 |
| A | MET116 |
| A | THR147 |
| A | SER148 |
| A | GLY149 |
| A | PHE219 |
| A | GLN223 |
| A | ARG225 |
| A | ILE253 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CO A 1 |
| Chain | Residue |
| A | HIS79 |
| A | HIS212 |
| A | ALA248 |
| A | HOH354 |
| A | HOH399 |
| A | HOH471 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CO A 2 |
| Chain | Residue |
| A | ASP33 |
| A | HIS133 |
| A | HOH383 |
| A | HOH437 |
| A | HOH488 |
| A | HOH521 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG A 315 |
| Chain | Residue |
| A | ASP280 |
| A | ASP283 |
| A | HOH516 |
| A | HOH532 |
| A | HOH579 |
| A | HOH590 |
| A | HOH598 |
Functional Information from PROSITE/UniProt
| site_id | PS01232 |
| Number of Residues | 16 |
| Details | PNP_UDP_1 Purine and other phosphorylases family 1 signature. ShGMGiPSiSImlhEL |
| Chain | Residue | Details |
| A | SER113-LEU128 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21855639","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3P0E","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21855639","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"2XRF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P0E","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3P0F","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
