3P0F
Structure of hUPP2 in an inactive conformation with bound 5-benzylacyclouridine
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004850 | molecular_function | uridine phosphorylase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006218 | biological_process | uridine catabolic process |
A | 0006249 | biological_process | dCMP catabolic process |
A | 0009116 | biological_process | nucleoside metabolic process |
A | 0009164 | biological_process | nucleoside catabolic process |
A | 0009166 | biological_process | nucleotide catabolic process |
A | 0016757 | molecular_function | glycosyltransferase activity |
A | 0016763 | molecular_function | pentosyltransferase activity |
A | 0042802 | molecular_function | identical protein binding |
A | 0044206 | biological_process | UMP salvage |
A | 0045098 | cellular_component | type III intermediate filament |
A | 0046108 | biological_process | uridine metabolic process |
A | 0047847 | molecular_function | deoxyuridine phosphorylase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 16 |
Details | BINDING SITE FOR RESIDUE BAU A 400 |
Chain | Residue |
A | HIS42 |
A | GLU254 |
A | MET255 |
A | ASP285 |
A | ILE287 |
A | HOH407 |
A | HOH465 |
A | HOH486 |
A | MET116 |
A | THR147 |
A | SER148 |
A | GLY149 |
A | PHE219 |
A | GLN223 |
A | ARG225 |
A | ILE253 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CO A 1 |
Chain | Residue |
A | HIS79 |
A | HIS212 |
A | ALA248 |
A | HOH354 |
A | HOH399 |
A | HOH471 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CO A 2 |
Chain | Residue |
A | ASP33 |
A | HIS133 |
A | HOH383 |
A | HOH437 |
A | HOH488 |
A | HOH521 |
site_id | AC4 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MG A 315 |
Chain | Residue |
A | ASP280 |
A | ASP283 |
A | HOH516 |
A | HOH532 |
A | HOH579 |
A | HOH590 |
A | HOH598 |
Functional Information from PROSITE/UniProt
site_id | PS01232 |
Number of Residues | 16 |
Details | PNP_UDP_1 Purine and other phosphorylases family 1 signature. ShGMGiPSiSImlhEL |
Chain | Residue | Details |
A | SER113-LEU128 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:21855639, ECO:0007744|PDB:3P0E |
Chain | Residue | Details |
A | GLY66 | |
A | ARG100 | |
A | ARG144 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000305|PubMed:21855639, ECO:0007744|PDB:2XRF, ECO:0007744|PDB:3P0E, ECO:0007744|PDB:3P0F |
Chain | Residue | Details |
A | SER148 | |
A | GLN223 |