3OV1
Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A 174 |
| Chain | Residue |
| A | SER75 |
| A | HOH201 |
| A | GLN77 |
| A | ARG78 |
| A | ASP94 |
| A | LYS100 |
| A | LEU111 |
| A | ARG112 |
| A | HOH192 |
| A | HOH197 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE GOL A 6 |
| Chain | Residue |
| A | HOH35 |
| A | ASP113 |
| A | TRP121 |
| A | LYS124 |
| A | HIS135 |
| A | THR138 |
| A | SER139 |
| A | SER141 |
| A | ARG142 |
| A | HOH204 |
| A | HOH233 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FMT A 7 |
| Chain | Residue |
| A | HOH19 |
| A | GLN77 |
| A | ARG78 |
| A | HIS79 |
| A | LYS109 |
| A | GLU152 |
| A | HOH208 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NA A 8 |
| Chain | Residue |
| A | ASP94 |
| A | PHE95 |
| A | VAL110 |
| A | HOH203 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 92 |
| Details | Domain: {"description":"SH2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"34348893","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
