Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3OUG

Crystal structure of cleaved L-aspartate-alpha-decarboxylase from Francisella tularensis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004068	molecular_function	aspartate 1-decarboxylase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006523	biological_process	alanine biosynthetic process
A	0015940	biological_process	pantothenate biosynthetic process
A	0016831	molecular_function	carboxy-lyase activity
B	0004068	molecular_function	aspartate 1-decarboxylase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006523	biological_process	alanine biosynthetic process
B	0015940	biological_process	pantothenate biosynthetic process
B	0016831	molecular_function	carboxy-lyase activity
C	0004068	molecular_function	aspartate 1-decarboxylase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006523	biological_process	alanine biosynthetic process
C	0015940	biological_process	pantothenate biosynthetic process
C	0016831	molecular_function	carboxy-lyase activity
E	0004068	molecular_function	aspartate 1-decarboxylase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006523	biological_process	alanine biosynthetic process
E	0015940	biological_process	pantothenate biosynthetic process
E	0016831	molecular_function	carboxy-lyase activity
F	0004068	molecular_function	aspartate 1-decarboxylase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006523	biological_process	alanine biosynthetic process
F	0015940	biological_process	pantothenate biosynthetic process
F	0016831	molecular_function	carboxy-lyase activity
G	0004068	molecular_function	aspartate 1-decarboxylase activity
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006523	biological_process	alanine biosynthetic process
G	0015940	biological_process	pantothenate biosynthetic process
G	0016831	molecular_function	carboxy-lyase activity
H	0004068	molecular_function	aspartate 1-decarboxylase activity
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006523	biological_process	alanine biosynthetic process
H	0015940	biological_process	pantothenate biosynthetic process
H	0016831	molecular_function	carboxy-lyase activity
I	0004068	molecular_function	aspartate 1-decarboxylase activity
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006523	biological_process	alanine biosynthetic process
I	0015940	biological_process	pantothenate biosynthetic process
I	0016831	molecular_function	carboxy-lyase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL A 201

Chain	Residue
A	SER25
A	ASN72
A	PRO74
A	ALA75
C	ARG54
C	HOH318

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 112

Chain	Residue
B	HOH261
A	ARG54
B	PRO74
B	ALA75

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 302

Chain	Residue
A	SER4
B	SER4
B	LYS43
B	TYR90
B	HOH209
B	HOH658
E	LYS43

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL B 201

Chain	Residue
B	ARG54
E	SER25
E	ASN72
E	PRO74
E	ALA75
E	HOH368

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL C 201

Chain	Residue
C	SER25
C	ASN72
C	PRO74
C	ALA75
C	HOH439
E	ARG54

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL C 302

Chain	Residue
A	LYS43
C	SER4
C	LYS43
C	GLU56
C	TYR90
C	HOH187
C	HOH684
C	HOH1050

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL F 201

Chain	Residue
F	ARG54
I	ASN72
I	PRO74
I	ALA75
I	HOH121

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL F 301

Chain	Residue
F	LYS43
F	TYR90
F	HOH303
F	HOH1034
F	HOH1125
H	SER4
H	GOL112
I	LYS43

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL G 301

Chain	Residue
F	SER4
G	LYS43
G	HOH199
G	HOH698
G	HOH1082
H	GOL301
I	SER4
I	GLN92
I	HOH323

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL G 201

Chain	Residue
G	ARG54
H	PRO74
H	ALA75
H	HOH960

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL H 201

Chain	Residue
F	PRO74
F	ALA75
H	ARG54
H	HOH215

site_id	BC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL H 301

Chain	Residue
G	LYS43
G	TYR90
G	GOL301
H	LYS43
H	GOL112
H	HOH152
H	HOH327
H	HOH451
I	SER4

site_id	BC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GOL H 112

Chain	Residue
F	LYS43
F	GOL301
G	SER4
H	SER4
H	LYS43
H	TYR90
H	GLN92
H	HOH161
H	GOL301
H	HOH598
H	HOH1078

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL I 201

Chain	Residue
G	PRO74
G	ALA75
I	ARG54
I	HOH181

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Schiff-base intermediate with substrate; via pyruvic acid => ECO:0000255\|HAMAP-Rule:MF_00446

Chain	Residue	Details
A	SER25
B	SER25
C	SER25
E	SER25
F	SER25
G	SER25
H	SER25
I	SER25

site_id	SWS_FT_FI2
Number of Residues	8
Details	ACT_SITE: Proton donor => ECO:0000255\|HAMAP-Rule:MF_00446

Chain	Residue	Details
A	TYR58
B	TYR58
C	TYR58
E	TYR58
F	TYR58
G	TYR58
H	TYR58
I	TYR58

site_id	SWS_FT_FI3
Number of Residues	16
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00446

Chain	Residue	Details
A	THR57
F	GLY73
G	THR57
G	GLY73
H	THR57
H	GLY73
I	THR57
I	GLY73
A	GLY73
B	THR57
B	GLY73
C	THR57
C	GLY73
E	THR57
E	GLY73
F	THR57

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: Pyruvic acid (Ser) => ECO:0000255\|HAMAP-Rule:MF_00446

Chain	Residue	Details
A	SER25
B	SER25
C	SER25
E	SER25
F	SER25
G	SER25
H	SER25
I	SER25

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)