3OTD

Crystal structure of human tRNAHis guanylyltransferase (Thg1)- NaI derivative

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0000166	molecular_function	nucleotide binding
A	0000287	molecular_function	magnesium ion binding
A	0005085	molecular_function	guanyl-nucleotide exchange factor activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005829	cellular_component	cytosol
A	0006400	biological_process	tRNA modification
A	0006979	biological_process	response to oxidative stress
A	0008033	biological_process	tRNA processing
A	0008053	biological_process	mitochondrial fusion
A	0008193	molecular_function	tRNA guanylyltransferase activity
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0051289	biological_process	protein homotetramerization
A	0099116	biological_process	tRNA 5'-end processing
A	1990046	biological_process	stress-induced mitochondrial fusion
A	1990234	cellular_component	transferase complex
B	0000049	molecular_function	tRNA binding
B	0000166	molecular_function	nucleotide binding
B	0000287	molecular_function	magnesium ion binding
B	0005085	molecular_function	guanyl-nucleotide exchange factor activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005741	cellular_component	mitochondrial outer membrane
B	0005829	cellular_component	cytosol
B	0006400	biological_process	tRNA modification
B	0006979	biological_process	response to oxidative stress
B	0008033	biological_process	tRNA processing
B	0008053	biological_process	mitochondrial fusion
B	0008193	molecular_function	tRNA guanylyltransferase activity
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0042802	molecular_function	identical protein binding
B	0046872	molecular_function	metal ion binding
B	0051289	biological_process	protein homotetramerization
B	0099116	biological_process	tRNA 5'-end processing
B	1990046	biological_process	stress-induced mitochondrial fusion
B	1990234	cellular_component	transferase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 270

Chain	Residue
A	MET205

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site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 271

Chain	Residue
B	ARG207

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site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 272

Chain	Residue
A	PRO204
A	MET205

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site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 273

Chain	Residue
A	GLN166
A	GLN167

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site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 274

Chain	Residue
A	ARG92

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site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 275

Chain	Residue
A	HIS152
A	ARG207

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site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD B 270

Chain	Residue
B	MET205

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site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD B 271

Chain	Residue
B	PRO204
B	MET205

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site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD B 272

Chain	Residue
B	ARG92

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site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD B 273

Chain	Residue
B	GLN166
B	GLN167

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21059936","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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