3OS5

SET7/9-Dnmt1 K142me1 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005694	cellular_component	chromosome
A	0006355	biological_process	regulation of DNA-templated transcription
A	0016279	molecular_function	protein-lysine N-methyltransferase activity
A	0140945	molecular_function	histone H3K4 monomethyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE BME A 500

Chain	Residue
A	ASP194
A	LYS195
A	CYS200
A	SER202
A	GLU272

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 391

Chain	Residue
A	ASN302
A	ARG323
A	HOH15
A	HOH50
A	THR300
A	PRO301

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 392

Chain	Residue
A	TYR217
A	GLU220
A	PHE231
A	HOH381

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 393

Chain	Residue
A	HOH74
A	GLU228
A	ASN282
A	HIS283
A	LYS294
A	SAH1501

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 394

Chain	Residue
A	TRP120
A	TYR122
A	TYR122

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 395

Chain	Residue
A	GLU163
A	ASP256
B	PRO138

---

site_id	AC7
Number of Residues	16
Details	BINDING SITE FOR RESIDUE SAH A 1501

Chain	Residue
A	HOH14
A	HOH36
A	HOH52
A	HOH74
A	ALA226
A	GLU228
A	ASN265
A	HIS293
A	LYS294
A	ASN296
A	HIS297
A	TYR335
A	TRP352
A	GLU356
A	EDO393
B	MLZ142

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	122
Details	Domain: {"description":"SET","evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12514135","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12540855","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00190","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12514135","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12540855","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	Site: {"description":"Histone H3K4 binding","evidences":[{"source":"PubMed","id":"12540855","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	5
Details	M-CSA 350

Chain	Residue	Details
A	TYR245	activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor
A	HIS293	electrostatic stabiliser, hydrogen bond acceptor
A	HIS297	electrostatic stabiliser, hydrogen bond acceptor
A	TYR305	activator, electrostatic stabiliser, hydrogen bond acceptor
A	TYR335	activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

---