3ORV
Crystal Structure of the Y294H-MauG/pre-Methylamine Dehydrogenase Complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004130 | molecular_function | cytochrome-c peroxidase activity |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0020037 | molecular_function | heme binding |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| B | 0004130 | molecular_function | cytochrome-c peroxidase activity |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0020037 | molecular_function | heme binding |
| B | 0042597 | cellular_component | periplasmic space |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0098869 | biological_process | cellular oxidant detoxification |
| C | 0009308 | biological_process | amine metabolic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016638 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors |
| C | 0030058 | molecular_function | amine dehydrogenase activity |
| C | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| C | 0042597 | cellular_component | periplasmic space |
| C | 0052876 | molecular_function | methylamine dehydrogenase (amicyanin) activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0030058 | molecular_function | amine dehydrogenase activity |
| D | 0030416 | biological_process | methylamine metabolic process |
| D | 0042597 | cellular_component | periplasmic space |
| D | 0052876 | molecular_function | methylamine dehydrogenase (amicyanin) activity |
| E | 0009308 | biological_process | amine metabolic process |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0016638 | molecular_function | oxidoreductase activity, acting on the CH-NH2 group of donors |
| E | 0030058 | molecular_function | amine dehydrogenase activity |
| E | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| E | 0042597 | cellular_component | periplasmic space |
| E | 0052876 | molecular_function | methylamine dehydrogenase (amicyanin) activity |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0030058 | molecular_function | amine dehydrogenase activity |
| F | 0030416 | biological_process | methylamine metabolic process |
| F | 0042597 | cellular_component | periplasmic space |
| F | 0052876 | molecular_function | methylamine dehydrogenase (amicyanin) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA A 400 |
| Chain | Residue |
| A | ASN66 |
| A | THR275 |
| A | PRO277 |
| A | HOH376 |
| A | HOH377 |
| A | HOH384 |
| A | HOH395 |
| site_id | AC2 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE HEC A 500 |
| Chain | Residue |
| A | CYS31 |
| A | CYS34 |
| A | HIS35 |
| A | VAL55 |
| A | ARG65 |
| A | THR67 |
| A | PRO68 |
| A | LEU70 |
| A | GLN91 |
| A | PHE92 |
| A | TRP93 |
| A | ARG96 |
| A | LEU100 |
| A | GLN103 |
| A | ALA104 |
| A | PRO107 |
| A | MET114 |
| A | GLN163 |
| A | LYS265 |
| A | HOH444 |
| A | HOH515 |
| A | HOH1053 |
| A | HOH1114 |
| A | GLN29 |
| A | SER30 |
| site_id | AC3 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE HEC A 600 |
| Chain | Residue |
| A | TRP93 |
| A | ASN200 |
| A | CYS201 |
| A | CYS204 |
| A | HIS205 |
| A | HIS224 |
| A | ILE226 |
| A | LEU228 |
| A | PHE264 |
| A | PRO267 |
| A | LEU269 |
| A | TYR278 |
| A | MET279 |
| A | HIS280 |
| A | LEU287 |
| A | HIS294 |
| A | SER324 |
| A | GLU327 |
| A | HOH377 |
| A | HOH384 |
| A | HOH422 |
| A | HOH440 |
| A | HOH443 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA B 400 |
| Chain | Residue |
| B | ASN66 |
| B | THR275 |
| B | PRO277 |
| B | HOH383 |
| B | HOH399 |
| B | HOH413 |
| B | HOH431 |
| site_id | AC5 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE HEC B 500 |
| Chain | Residue |
| B | GLN29 |
| B | SER30 |
| B | CYS31 |
| B | CYS34 |
| B | HIS35 |
| B | SER54 |
| B | ARG65 |
| B | THR67 |
| B | PRO68 |
| B | LEU70 |
| B | GLN91 |
| B | PHE92 |
| B | TRP93 |
| B | ARG96 |
| B | LEU100 |
| B | GLN103 |
| B | ALA104 |
| B | PRO107 |
| B | GLN163 |
| B | LYS265 |
| B | HOH530 |
| B | HOH582 |
| B | HOH727 |
| B | HOH838 |
| site_id | AC6 |
| Number of Residues | 23 |
| Details | BINDING SITE FOR RESIDUE HEC B 600 |
| Chain | Residue |
| B | HIS280 |
| B | LEU287 |
| B | HIS294 |
| B | SER324 |
| B | GLU327 |
| B | HOH376 |
| B | HOH399 |
| B | HOH413 |
| B | HOH423 |
| B | HOH428 |
| B | TRP93 |
| B | ASN200 |
| B | CYS201 |
| B | CYS204 |
| B | HIS205 |
| B | HIS224 |
| B | ILE226 |
| B | LEU228 |
| B | PHE264 |
| B | PRO267 |
| B | LEU269 |
| B | TYR278 |
| B | MET279 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO B 374 |
| Chain | Residue |
| B | ALA164 |
| B | ARG215 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PGE D 387 |
| Chain | Residue |
| D | THR187 |
| D | LYS236 |
| D | LEU254 |
| D | SER255 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO D 388 |
| Chain | Residue |
| D | ASP87 |
| D | PRO146 |
| D | GLN235 |
| site_id | BC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PEG D 389 |
| Chain | Residue |
| C | ASP32 |
| C | GLY33 |
| C | PRO87 |
| C | CYS88 |
| D | HIS54 |
| D | HOH1138 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG E 138 |
| Chain | Residue |
| E | ASP32 |
| E | GLY33 |
| E | PRO87 |
| F | HIS54 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PG4 F 387 |
| Chain | Residue |
| F | THR187 |
| F | LYS236 |
| F | LEU254 |
| F | SER255 |
| F | HOH800 |
| site_id | BC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PG4 F 388 |
| Chain | Residue |
| D | VAL98 |
| D | PHE99 |
| D | SER100 |
| D | GLU106 |
| D | THR108 |
| F | VAL98 |
| F | PHE99 |
| F | SER100 |
| F | GLU106 |
| F | THR108 |
| F | HOH528 |
| site_id | BC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE P6G F 389 |
| Chain | Residue |
| A | ARG125 |
| A | ASP128 |
| F | VAL219 |
| F | PHE261 |
| F | LEU262 |
| F | HOH840 |
| F | HOH1206 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PEG F 390 |
| Chain | Residue |
| F | VAL85 |
| F | ASP87 |
| F | THR145 |
| F | GLY148 |
| F | GLN235 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO F 391 |
| Chain | Residue |
| F | ARG293 |
| F | LEU324 |
| F | GLU362 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | MOD_RES: Tryptophylquinone => ECO:0000269|PubMed:1409575 |
| Chain | Residue | Details |
| C | 0AF57 | |
| E | 0AF57 | |
| A | CYS201 | |
| A | CYS204 | |
| B | CYS31 | |
| B | CYS34 | |
| B | CYS201 | |
| B | CYS204 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | CROSSLNK: Tryptophan tryptophylquinone (Trp-Trp) => ECO:0000269|PubMed:1409575 |
| Chain | Residue | Details |
| C | 0AF57 | |
| C | TRP108 | |
| E | 0AF57 | |
| E | TRP108 | |
| B | HIS205 | |
| B | HIS280 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 13 |
| Chain | Residue | Details |
| C | ASP32 | electrostatic stabiliser, proton acceptor, proton donor |
| C | 0AF57 | proton acceptor, proton donor, proton relay |
| C | ASP76 | electrostatic stabiliser, proton acceptor, proton donor |
| C | TRP108 | proton acceptor, proton donor, proton relay, single electron donor |
| C | TYR119 | steric role |
| C | THR122 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 6 |
| Details | M-CSA 13 |
| Chain | Residue | Details |
| E | ASP32 | electrostatic stabiliser, proton acceptor, proton donor |
| E | 0AF57 | proton acceptor, proton donor, proton relay |
| E | ASP76 | electrostatic stabiliser, proton acceptor, proton donor |
| E | TRP108 | proton acceptor, proton donor, proton relay, single electron donor |
| E | TYR119 | steric role |
| E | THR122 | electrostatic stabiliser |
