3ORH

Human guanidinoacetate N-methyltransferase with SAH

Replaces:  1ZX0

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006600	biological_process	creatine metabolic process
A	0006601	biological_process	creatine biosynthetic process
A	0006936	biological_process	muscle contraction
A	0007283	biological_process	spermatogenesis
A	0008168	molecular_function	methyltransferase activity
A	0009887	biological_process	animal organ morphogenesis
A	0016740	molecular_function	transferase activity
A	0030731	molecular_function	guanidinoacetate N-methyltransferase activity
A	0032259	biological_process	methylation
A	0040014	biological_process	regulation of multicellular organism growth
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006600	biological_process	creatine metabolic process
B	0006601	biological_process	creatine biosynthetic process
B	0006936	biological_process	muscle contraction
B	0007283	biological_process	spermatogenesis
B	0008168	molecular_function	methyltransferase activity
B	0009887	biological_process	animal organ morphogenesis
B	0016740	molecular_function	transferase activity
B	0030731	molecular_function	guanidinoacetate N-methyltransferase activity
B	0032259	biological_process	methylation
B	0040014	biological_process	regulation of multicellular organism growth
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006600	biological_process	creatine metabolic process
C	0006601	biological_process	creatine biosynthetic process
C	0006936	biological_process	muscle contraction
C	0007283	biological_process	spermatogenesis
C	0008168	molecular_function	methyltransferase activity
C	0009887	biological_process	animal organ morphogenesis
C	0016740	molecular_function	transferase activity
C	0030731	molecular_function	guanidinoacetate N-methyltransferase activity
C	0032259	biological_process	methylation
C	0040014	biological_process	regulation of multicellular organism growth
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006600	biological_process	creatine metabolic process
D	0006601	biological_process	creatine biosynthetic process
D	0006936	biological_process	muscle contraction
D	0007283	biological_process	spermatogenesis
D	0008168	molecular_function	methyltransferase activity
D	0009887	biological_process	animal organ morphogenesis
D	0016740	molecular_function	transferase activity
D	0030731	molecular_function	guanidinoacetate N-methyltransferase activity
D	0032259	biological_process	methylation
D	0040014	biological_process	regulation of multicellular organism growth

Functional Information from PDB Data

site_id	AC1
Number of Residues	24
Details	BINDING SITE FOR RESIDUE SAH A 4000

Chain	Residue
A	TRP20
A	ILE73
A	ALA74
A	GLU90
A	CYS91
A	ASN92
A	VAL95
A	GLY115
A	LEU116
A	TRP117
A	GLU118
A	ILE36
A	ASP135
A	THR136
A	TYR137
A	HOH246
A	HOH256
A	MET42
A	MET50
A	GLY68
A	PHE69
A	GLY70
A	MET71
A	ALA72

---

site_id	AC2
Number of Residues	25
Details	BINDING SITE FOR RESIDUE SAH B 4001

Chain	Residue
B	TRP20
B	ILE36
B	MET42
B	MET50
B	GLY68
B	PHE69
B	GLY70
B	MET71
B	ALA72
B	ILE73
B	ALA74
B	GLU90
B	CYS91
B	ASN92
B	VAL95
B	GLY115
B	LEU116
B	TRP117
B	GLU118
B	ASP135
B	THR136
B	TYR137
B	LEU139
B	HOH530
B	HOH750

---

site_id	AC3
Number of Residues	24
Details	BINDING SITE FOR RESIDUE SAH C 4002

Chain	Residue
C	TRP20
C	ILE36
C	MET42
C	MET50
C	GLY68
C	PHE69
C	GLY70
C	MET71
C	ALA72
C	ILE73
C	ALA74
C	GLU90
C	CYS91
C	ASN92
C	VAL95
C	GLY115
C	LEU116
C	TRP117
C	GLU118
C	ASP135
C	THR136
C	TYR137
C	LEU139
C	HOH298

---

site_id	AC4
Number of Residues	26
Details	BINDING SITE FOR RESIDUE SAH D 4003

Chain	Residue
D	TRP20
D	ILE36
D	VAL41
D	MET42
D	MET50
D	GLY68
D	PHE69
D	GLY70
D	MET71
D	ALA72
D	ILE73
D	ALA74
D	GLU90
D	CYS91
D	ASN92
D	VAL95
D	GLY115
D	LEU116
D	TRP117
D	GLU118
D	ASP135
D	THR136
D	TYR137
D	LEU139
D	HOH253
D	HOH400

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	669
Details	Domain: {"description":"RMT2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00892","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	44
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P10868","evidenceCode":"ECO:0000250"},{"source":"PROSITE-ProRule","id":"PRU00892","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P10868","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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