3ORF

Crystal Structure of Dihydropteridine Reductase from Dictyostelium discoideum

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004155	molecular_function	6,7-dihydropteridine reductase activity
A	0005737	cellular_component	cytoplasm
A	0006559	biological_process	L-phenylalanine catabolic process
A	0006729	biological_process	tetrahydrobiopterin biosynthetic process
A	0006979	biological_process	response to oxidative stress
A	0016491	molecular_function	oxidoreductase activity
A	0042558	biological_process	pteridine-containing compound metabolic process
A	0042802	molecular_function	identical protein binding
A	0045335	cellular_component	phagocytic vesicle
A	0051287	molecular_function	NAD binding
A	0070402	molecular_function	NADPH binding
A	0070404	molecular_function	NADH binding
B	0004155	molecular_function	6,7-dihydropteridine reductase activity
B	0005737	cellular_component	cytoplasm
B	0006559	biological_process	L-phenylalanine catabolic process
B	0006729	biological_process	tetrahydrobiopterin biosynthetic process
B	0006979	biological_process	response to oxidative stress
B	0016491	molecular_function	oxidoreductase activity
B	0042558	biological_process	pteridine-containing compound metabolic process
B	0042802	molecular_function	identical protein binding
B	0045335	cellular_component	phagocytic vesicle
B	0051287	molecular_function	NAD binding
B	0070402	molecular_function	NADPH binding
B	0070404	molecular_function	NADH binding
C	0004155	molecular_function	6,7-dihydropteridine reductase activity
C	0005737	cellular_component	cytoplasm
C	0006559	biological_process	L-phenylalanine catabolic process
C	0006729	biological_process	tetrahydrobiopterin biosynthetic process
C	0006979	biological_process	response to oxidative stress
C	0016491	molecular_function	oxidoreductase activity
C	0042558	biological_process	pteridine-containing compound metabolic process
C	0042802	molecular_function	identical protein binding
C	0045335	cellular_component	phagocytic vesicle
C	0051287	molecular_function	NAD binding
C	0070402	molecular_function	NADPH binding
C	0070404	molecular_function	NADH binding
D	0004155	molecular_function	6,7-dihydropteridine reductase activity
D	0005737	cellular_component	cytoplasm
D	0006559	biological_process	L-phenylalanine catabolic process
D	0006729	biological_process	tetrahydrobiopterin biosynthetic process
D	0006979	biological_process	response to oxidative stress
D	0016491	molecular_function	oxidoreductase activity
D	0042558	biological_process	pteridine-containing compound metabolic process
D	0042802	molecular_function	identical protein binding
D	0045335	cellular_component	phagocytic vesicle
D	0051287	molecular_function	NAD binding
D	0070402	molecular_function	NADPH binding
D	0070404	molecular_function	NADH binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	28
Details	BINDING SITE FOR RESIDUE NAD A 901

Chain	Residue
A	LEU8
A	ALA75
A	GLY76
A	GLY77
A	ASP97
A	MET98
A	ASN99
A	SER102
A	GLY124
A	ALA125
A	TYR138
A	GLY12
A	LYS142
A	PRO170
A	VAL171
A	THR172
A	LEU173
A	THR175
A	ASN178
A	HOH253
A	HOH269
A	ALA13
A	LEU14
A	ASP33
A	PHE34
A	ARG35
A	SER49
A	ALA74

---

site_id	AC2
Number of Residues	24
Details	BINDING SITE FOR RESIDUE NAD B 902

Chain	Residue
B	GLY12
B	ALA13
B	LEU14
B	ASP33
B	PHE34
B	ARG35
B	SER49
B	ALA74
B	ALA75
B	GLY76
B	GLY77
B	ASP97
B	MET98
B	THR123
B	GLY124
B	TYR138
B	LYS142
B	PRO170
B	LEU173
B	THR175
B	ASN178
B	HOH236
B	HOH239
B	HOH242

---

site_id	AC3
Number of Residues	27
Details	BINDING SITE FOR RESIDUE NAD C 903

Chain	Residue
C	LEU8
C	GLY12
C	ALA13
C	LEU14
C	ASP33
C	PHE34
C	ARG35
C	SER49
C	ALA74
C	ALA75
C	GLY76
C	GLY77
C	ASP97
C	MET98
C	THR123
C	GLY124
C	TYR138
C	LYS142
C	PRO170
C	VAL171
C	THR172
C	LEU173
C	THR175
C	HOH232
C	HOH262
D	SER183
D	ASP184

---

site_id	AC4
Number of Residues	27
Details	BINDING SITE FOR RESIDUE NAD D 904

Chain	Residue
D	LYS142
D	PRO170
D	THR172
D	LEU173
D	ASN178
D	HOH236
D	HOH255
C	SER183
C	ASP184
D	LEU8
D	GLY12
D	ALA13
D	LEU14
D	ASP33
D	PHE34
D	ARG35
D	SER49
D	ALA74
D	ALA75
D	GLY76
D	GLY77
D	ASP97
D	MET98
D	SER102
D	THR123
D	GLY124
D	TYR138

---

Functional Information from PROSITE/UniProt

site_id	PS00061
Number of Residues	29
Details	ADH_SHORT Short-chain dehydrogenases/reductases family signature. AsaalnrtsgMiaYGATKAAThHIIkDLA

Chain	Residue	Details
A	ALA125-ALA153

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10001","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	96
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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