3OML

Structure of full-length peroxisomal multifunctional enzyme type 2 from Drosophila melanogaster

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003857	molecular_function	3-hydroxyacyl-CoA dehydrogenase activity
A	0004300	molecular_function	enoyl-CoA hydratase activity
A	0004303	molecular_function	estradiol 17-beta-dehydrogenase [NAD(P)+] activity
A	0005777	cellular_component	peroxisome
A	0006631	biological_process	fatty acid metabolic process
A	0006635	biological_process	fatty acid beta-oxidation
A	0016491	molecular_function	oxidoreductase activity
A	0016829	molecular_function	lyase activity
A	0018812	molecular_function	3-hydroxyacyl-CoA dehydratase activity
A	0033540	biological_process	fatty acid beta-oxidation using acyl-CoA oxidase
A	0042803	molecular_function	protein homodimerization activity
A	0044594	molecular_function	17-beta-hydroxysteroid dehydrogenase (NAD+) activity
A	0106386	molecular_function	(3R)-hydroxyacyl-CoA dehydrogenase (NAD+) activity

Functional Information from PROSITE/UniProt

site_id	PS00061
Number of Residues	29
Details	ADH_SHORT Short-chain dehydrogenases/reductases family signature. SnsgiygnfgQvnYTAAKMGLiGLAnTVA

Chain	Residue	Details
A	SER154-ALA182

---

site_id	PS00639
Number of Residues	11
Details	THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. ILHGLCTLGFS

Chain	Residue	Details
A	ILE516-SER526

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P51659, ECO:0000255|PROSITE-ProRule:PRU10001

Chain	Residue	Details
A	TYR167

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P51659

Chain	Residue	Details
A	VAL16
A	LEU24
A	ASP43
A	SER78
A	ASN102
A	SER154
A	TYR167
A	ALA199

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P22414

Chain	Residue	Details
A	HIS390
A	LYS419
A	ASP496
A	GLY519
A	PHE549

---