3OJY
Crystal Structure of Human Complement Component C8
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001848 | molecular_function | complement binding |
| A | 0002376 | biological_process | immune system process |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005579 | cellular_component | membrane attack complex |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006955 | biological_process | immune response |
| A | 0006956 | biological_process | complement activation |
| A | 0006957 | biological_process | complement activation, alternative pathway |
| A | 0006958 | biological_process | complement activation, classical pathway |
| A | 0016020 | cellular_component | membrane |
| A | 0022829 | molecular_function | wide pore channel activity |
| A | 0031640 | biological_process | killing of cells of another organism |
| A | 0044218 | cellular_component | other organism cell membrane |
| A | 0044877 | molecular_function | protein-containing complex binding |
| A | 0045087 | biological_process | innate immune response |
| A | 0050778 | biological_process | positive regulation of immune response |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0072562 | cellular_component | blood microparticle |
| A | 0160257 | biological_process | complement activation, GZMK pathway |
| B | 0002376 | biological_process | immune system process |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005579 | cellular_component | membrane attack complex |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006955 | biological_process | immune response |
| B | 0006956 | biological_process | complement activation |
| B | 0006957 | biological_process | complement activation, alternative pathway |
| B | 0006958 | biological_process | complement activation, classical pathway |
| B | 0016020 | cellular_component | membrane |
| B | 0022829 | molecular_function | wide pore channel activity |
| B | 0031640 | biological_process | killing of cells of another organism |
| B | 0044218 | cellular_component | other organism cell membrane |
| B | 0044877 | molecular_function | protein-containing complex binding |
| B | 0045087 | biological_process | innate immune response |
| B | 0050778 | biological_process | positive regulation of immune response |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0160257 | biological_process | complement activation, GZMK pathway |
| B | 1903561 | cellular_component | extracellular vesicle |
| C | 0002376 | biological_process | immune system process |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005579 | cellular_component | membrane attack complex |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006956 | biological_process | complement activation |
| C | 0006957 | biological_process | complement activation, alternative pathway |
| C | 0006958 | biological_process | complement activation, classical pathway |
| C | 0019841 | molecular_function | retinol binding |
| C | 0022829 | molecular_function | wide pore channel activity |
| C | 0031640 | biological_process | killing of cells of another organism |
| C | 0044218 | cellular_component | other organism cell membrane |
| C | 0045087 | biological_process | innate immune response |
| C | 0050778 | biological_process | positive regulation of immune response |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 0072562 | cellular_component | blood microparticle |
| C | 0160257 | biological_process | complement activation, GZMK pathway |
Functional Information from PROSITE/UniProt
| site_id | PS00022 |
| Number of Residues | 12 |
| Details | EGF_1 EGF-like domain signature 1. CqCrlGslGAaC |
| Chain | Residue | Details |
| A | CYS487-CYS498 | |
| B | CYS469-CYS480 |
| site_id | PS00213 |
| Number of Residues | 14 |
| Details | LIPOCALIN Lipocalin signature. NFDaqQFAGTWLLV |
| Chain | Residue | Details |
| C | ASN21-VAL34 |
| site_id | PS00279 |
| Number of Residues | 12 |
| Details | MACPF_1 Membrane attack complex/perforin (MACPF) domain signature. YakfindYGTHY |
| Chain | Residue | Details |
| A | TYR300-TYR311 | |
| B | TYR279-TYR290 |
| site_id | PS01209 |
| Number of Residues | 23 |
| Details | LDLRA_1 LDL-receptor class A (LDLRA) domain signature. CLkrhlv.CNgdqDCldgsDEDd....C |
| Chain | Residue | Details |
| A | CYS78-CYS100 | |
| B | CYS79-CYS101 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Beta stranded","evidences":[{"source":"PubMed","id":"30552328","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6H04","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 75 |
| Details | Domain: {"description":"LDL-receptor class A","evidences":[{"source":"PROSITE-ProRule","id":"PRU00124","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 60 |
| Details | Domain: {"description":"EGF-like"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21454577","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3OJY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Site: {"description":"Not glycosylated"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Glycosylation: {"description":"C-linked (Man) tryptophan","evidences":[{"source":"PubMed","id":"10551839","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 53 |
| Details | Domain: {"description":"TSP type-1 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00210","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"21454577","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30552328","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
