3OJS

Snapshots of the large fragment of DNA polymerase I from Thermus Aquaticus processing C5 modified thymidines

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001882	molecular_function	nucleoside binding
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006260	biological_process	DNA replication
A	0006261	biological_process	DNA-templated DNA replication
A	0006281	biological_process	DNA repair

Functional Information from PDB Data

site_id	AC1
Number of Residues	33
Details	BINDING SITE FOR RESIDUE XJS A 1

Chain	Residue
A	MG7
A	ARG587
A	ASP610
A	TYR611
A	SER612
A	GLN613
A	ILE614
A	GLU615
A	HIS639
A	ARG659
A	ARG660
A	MG8
A	LYS663
A	PHE667
A	ARG677
A	ASP785
A	HOH833
B	HOH28
B	DC111
B	DOC112
C	GOL8
C	HOH33
A	HOH33
C	HOH42
C	DA204
C	DG205
C	DG206
A	HOH115
A	HOH120
A	HOH162
A	HOH185
A	HOH248
A	ARG573

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 2

Chain	Residue
A	GOL6
A	HOH37
A	HOH55
A	HOH100
A	ASN485
A	SER486
A	ARG487
A	ASP488
C	DG211
C	DT212

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 3

Chain	Residue
A	HOH142
A	HOH219
A	HOH221
A	HOH282
A	ASP452
A	TYR455
A	ARG596
A	ILE599
A	ASP826

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 4

Chain	Residue
A	HOH126
A	HOH168
A	THR544
A	TYR545
A	PRO579
A	ASN580
A	ASN583
C	PGE6
C	DC209
C	DC210

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 5

Chain	Residue
A	HOH53
A	HOH176
A	ARG313
A	TRP318
A	ASP551
A	LEU552

---

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 6

Chain	Residue
A	GOL2
A	HOH37
A	HOH67
A	HOH125
A	HOH223
A	ASN485
A	ARG487
B	DG107
B	DG108
B	DC109

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 7

Chain	Residue
A	XJS1
A	MG8
A	ASP610
A	TYR611
A	ASP785

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG A 8

Chain	Residue
A	XJS1
A	MG7
A	HOH216
A	ASP610
A	ASP785
A	HOH833
B	DOC112

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PGE A 835

Chain	Residue
A	HOH188
A	HOH198
A	GLU462
A	GLU466
A	ARG593
A	GLU825

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT A 836

Chain	Residue
A	ARG425
A	PHE724
A	HOH58
A	HOH183
A	HOH220

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PGE A 837

Chain	Residue
A	HOH152
A	GLU742
A	GLU745
A	ARG746
C	DA203

---

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PGE A 838

Chain	Residue
A	HOH155
A	HOH166
A	VAL310
A	LEU311
A	ARG405

---

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT A 840

Chain	Residue
A	HOH150
A	HOH235
A	HOH235
A	TYR455
A	TYR455

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT A 841

Chain	Residue
A	TRP417
A	ARG431
A	ARG435

---

site_id	BC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GOL B 7

Chain	Residue
B	HOH21
B	HOH26
B	HOH27
B	HOH30
B	DC106
B	DG107
B	DG108
B	DC109
C	HOH27
C	HOH37
C	DG208
C	DC209

---

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PGE C 6

Chain	Residue
A	GOL4
A	HOH132
A	ASP578
C	DC209
C	DC210

---

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL C 8

Chain	Residue
A	XJS1
C	HOH24
C	DG205
C	DG206

---

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL C 9

Chain	Residue
A	ARG728
C	DG206
C	DC207

---

Functional Information from PROSITE/UniProt

site_id	PS00447
Number of Residues	20
Details	DNA_POLYMERASE_A DNA polymerase family A signature. RraAKtinFGvlYgmSahrL

Chain	Residue	Details
A	ARG659-LEU678

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